PMID- 29430855
OWN - NLM
STAT- MEDLINE
DCOM- 20200109
LR  - 20200725
IS  - 1601-183X (Electronic)
IS  - 1601-1848 (Print)
IS  - 1601-183X (Linking)
VI  - 18
IP  - 6
DP  - 2019 Jul
TI  - Dynorphinergic system alterations in the corticostriatal circuitry of neuropathic 
      mice support its role in the negative affective component of pain.
PG  - e12467
LID - 10.1111/gbb.12467 [doi]
LID - e12467
AB  - The dynorphinergic system is involved in pain transmission at spinal level, where 
      dynorphin exerts antinociceptive or pronociceptive effects, based on its opioid 
      or non-opioid actions. Surprisingly, little evidence is currently available 
      concerning the supraspinal role of the dynorphinergic system in pain conditions. 
      The present study aimed to investigate whether neuropathic pain is accompanied by 
      prodynorphin (Pdyn) and kappa-opioid receptor (Oprk1) gene expression alterations in 
      selected mouse brain areas. To this end, mice were subjected to chronic 
      constriction injury of the right sciatic nerve and neuropathic pain behavioral 
      signs were ascertained after 14 days. At this interval, a marked increase in Pdyn 
      mRNA in the anterior cingulate cortex (ACC) and prefrontal cortex (PFC) was 
      observed. Oprk1 gene expression was increased in the PFC, and decreased in the 
      ACC and nucleus accumbens (NAc). No changes were observed in the other 
      investigated regions. Because of the relationship between dynorphin and the 
      brain-derived neurotrophic factor, and the role of this neurotrophin in chronic 
      pain-related neuroplasticity, we investigated brain-derived neurotrophic factor 
      gene (Bdnf) expression in the areas showing Pdyn or Oprk1 mRNAs changes. Bdnf 
      mRNA levels were increased in both the ACC and PFC, whereas no changes were 
      assessed in the NAc. Present data indicate that the dynorphinergic system 
      undergoes quite selective alterations involving the corticostriatal circuitry 
      during neuropathic pain, suggesting a contribution to the negative affective 
      component of pain. Moreover, parallel increases in Pdyn and Bdnf mRNA at cortical 
      level suggest the occurrence of likely interactions between these systems in 
      neuropathic pain maladaptive neuroplasticity.
CI  - (c) 2018 The Authors. Genes, Brain and Behavior published by International 
      Behavioural and Neural Genetics Society and John Wiley & Sons Ltd.
FAU - Palmisano, M
AU  - Palmisano M
AD  - Department of Pharmacy and Biotechnology, Alma Mater Studiorum - University of 
      Bologna, Bologna, Italy.
FAU - Caputi, F F
AU  - Caputi FF
AD  - Department of Pharmacy and Biotechnology, Alma Mater Studiorum - University of 
      Bologna, Bologna, Italy.
FAU - Mercatelli, D
AU  - Mercatelli D
AD  - Department of Pharmacy and Biotechnology, Alma Mater Studiorum - University of 
      Bologna, Bologna, Italy.
FAU - Romualdi, P
AU  - Romualdi P
AD  - Department of Pharmacy and Biotechnology, Alma Mater Studiorum - University of 
      Bologna, Bologna, Italy.
FAU - Candeletti, S
AU  - Candeletti S
AUID- ORCID: 0000-0001-8905-7393
AD  - Department of Pharmacy and Biotechnology, Alma Mater Studiorum - University of 
      Bologna, Bologna, Italy.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180315
PL  - England
TA  - Genes Brain Behav
JT  - Genes, brain, and behavior
JID - 101129617
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Enkephalins)
RN  - 0 (Protein Precursors)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Opioid, kappa)
RN  - 0 (kappa(1) opioid receptor)
RN  - 93443-35-7 (preproenkephalin)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/genetics/metabolism
MH  - Cerebral Cortex/*metabolism/physiopathology
MH  - Enkephalins/*genetics/metabolism
MH  - Male
MH  - Mice
MH  - Neuralgia/*genetics/metabolism/physiopathology
MH  - Nucleus Accumbens/*metabolism/physiopathology
MH  - Protein Precursors/*genetics/metabolism
MH  - RNA, Messenger/genetics/metabolism
MH  - Receptors, Opioid, kappa/genetics/metabolism
PMC - PMC7379183
OTO - NOTNLM
OT  - Bdnf
OT  - Oprk1
OT  - Pdyn
OT  - anterior cingulate cortex
OT  - corticostriatal circuitry
OT  - gene expression
OT  - neuropathic pain
OT  - nucleus accumbens
OT  - pain aversion
OT  - prefrontal cortex
COIS- Authors declare that they have no conflicts of interest.
EDAT- 2018/02/13 06:00
MHDA- 2020/01/10 06:00
PMCR- 2020/07/24
CRDT- 2018/02/13 06:00
PHST- 2017/07/24 00:00 [received]
PHST- 2018/01/19 00:00 [revised]
PHST- 2018/02/07 00:00 [accepted]
PHST- 2018/02/13 06:00 [pubmed]
PHST- 2020/01/10 06:00 [medline]
PHST- 2018/02/13 06:00 [entrez]
PHST- 2020/07/24 00:00 [pmc-release]
AID - GBB12467 [pii]
AID - 10.1111/gbb.12467 [doi]
PST - ppublish
SO  - Genes Brain Behav. 2019 Jul;18(6):e12467. doi: 10.1111/gbb.12467. Epub 2018 Mar 
      15.