PMID- 29433388
OWN - NLM
STAT- MEDLINE
DCOM- 20180803
LR  - 20180803
IS  - 1793-6853 (Electronic)
IS  - 0192-415X (Linking)
VI  - 46
IP  - 2
DP  - 2018
TI  - Eucalyptus globulus Inhibits Inflammasome-Activated Pro-Inflammatory Responses 
      and Ameliorate Monosodium Urate-Induced Peritonitis in Murine Experimental Model.
PG  - 423-433
LID - 10.1142/S0192415X18500210 [doi]
AB  - Eucalyptus globulus Labill. (E. globulus, Myrtaceae) is used in Europe as a 
      traditional folk remedy for inflammation-related disorders such as arthritis, 
      diabetes, asthma, and gout. We investigated this study to evaluate the protective 
      effects of E. globulus extract (EG) on inflammatory responses, and provide 
      scientific and mechanistic evidence in in vitro and in vivo experimental models. 
      LPS-stimulated murine bone marrow-derived macrophages (BMDMs) were used to study 
      the regulatory effect of EG on inflammasome activation in vitro. Monosodium urate 
      (MSU)-induced peritonitis was used to study the effect of EG in an in vivo murine 
      model. EG suppressed IL-[Formula: see text] secretion via the regulation of 
      apoptosis-associated speck-like proteins containing a CARD (ASC) oligomerization 
      and caspase-1 maturation, leading to the inhibition of inflammasome activation. 
      In the in vivo study, EG suppressed the MSU-induced peritonitis by attenuating 
      interleukin (IL)-1[Formula: see text], providing scientific support for its 
      traditional use in the treatment of inflammation-related disorders.
FAU - Ji, Young-Eun
AU  - Ji YE
AD  - * Department of Applied Life Science, Graduate School, Konkuk University, 
      Chungju, Korea.
FAU - Sun, Xiao
AU  - Sun X
AD  - * Department of Applied Life Science, Graduate School, Konkuk University, 
      Chungju, Korea.
FAU - Kim, Myong-Ki
AU  - Kim MK
AD  - dagger Department of Food Science and Engineering, Seowon University, Cheongju, Korea.
FAU - Li, Wan Yi
AU  - Li WY
AD  - double dagger Institute of Medicinal Plants, Yunnan Academy of Agricultural Sciences, 
      Kunming, Yunnan, China.
FAU - Lee, Sang Woo
AU  - Lee SW
AD  -  section sign IBMRC, Korea Research Institute of Bioscience & Biotechnology, Daejeon, Korea.
FAU - Koppula, Sushruta
AU  - Koppula S
AD  -  paragraph sign Department of Biotechnology, College of Biomedical & Health Science, Research 
      Institute of Inflammatory Diseases, Chungju, Korea.
FAU - Yu, Sang-Hyeun
AU  - Yu SH
AD  - * Department of Applied Life Science, Graduate School, Konkuk University, 
      Chungju, Korea.
FAU - Kim, Han-Bi
AU  - Kim HB
AD  - * Department of Applied Life Science, Graduate School, Konkuk University, 
      Chungju, Korea.
FAU - Kang, Tae-Bong
AU  - Kang TB
AD  - * Department of Applied Life Science, Graduate School, Konkuk University, 
      Chungju, Korea.
AD  -  paragraph sign Department of Biotechnology, College of Biomedical & Health Science, Research 
      Institute of Inflammatory Diseases, Chungju, Korea.
FAU - Lee, Kwang-Ho
AU  - Lee KH
AD  - * Department of Applied Life Science, Graduate School, Konkuk University, 
      Chungju, Korea.
AD  -  paragraph sign Department of Biotechnology, College of Biomedical & Health Science, Research 
      Institute of Inflammatory Diseases, Chungju, Korea.
LA  - eng
PT  - Journal Article
DEP - 20180212
PL  - Singapore
TA  - Am J Chin Med
JT  - The American journal of Chinese medicine
JID - 7901431
RN  - 0 (CARD Signaling Adaptor Proteins)
RN  - 0 (Inflammasomes)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Plant Extracts)
RN  - 0 (Pycard protein, mouse)
RN  - 268B43MJ25 (Uric Acid)
RN  - EC 3.4.22.36 (Caspase 1)
SB  - IM
MH  - Animals
MH  - CARD Signaling Adaptor Proteins/metabolism
MH  - Caspase 1/metabolism
MH  - Cells, Cultured
MH  - Disease Models, Animal
MH  - Eucalyptus/*chemistry
MH  - Female
MH  - Inflammasomes/*metabolism
MH  - Inflammation/*drug therapy/genetics
MH  - Interleukin-1beta/metabolism
MH  - Lipopolysaccharides/adverse effects
MH  - Macrophages/*drug effects
MH  - Mice, Inbred C57BL
MH  - Peritonitis/*drug therapy/*etiology
MH  - *Phytotherapy
MH  - Plant Extracts/*pharmacology/*therapeutic use
MH  - Uric Acid/*adverse effects
OTO - NOTNLM
OT  - ASC
OT  - Eucalyptus globulus Labill
OT  - Inflammasome
OT  - Peritonitis
EDAT- 2018/02/13 06:00
MHDA- 2018/08/04 06:00
CRDT- 2018/02/14 06:00
PHST- 2018/02/13 06:00 [pubmed]
PHST- 2018/08/04 06:00 [medline]
PHST- 2018/02/14 06:00 [entrez]
AID - 10.1142/S0192415X18500210 [doi]
PST - ppublish
SO  - Am J Chin Med. 2018;46(2):423-433. doi: 10.1142/S0192415X18500210. Epub 2018 Feb 
      12.