PMID- 29434182
OWN - NLM
STAT- MEDLINE
DCOM- 20180817
LR  - 20190606
IS  - 1643-3750 (Electronic)
IS  - 1234-1010 (Print)
IS  - 1234-1010 (Linking)
VI  - 24
DP  - 2018 Feb 13
TI  - Corilagin Attenuates Allergy and Anaphylactic Reaction by Inhibiting 
      Degranulation of Mast Cells.
PG  - 891-896
AB  - BACKGROUND This study evaluated the anti-allergic activity of corilagin and also 
      postulates the possible mechanism of its action. MATERIAL AND METHODS Corilagin 
      was given orally at dose of 10, 20, and 40 mg/kg/day. All the animals (guinea 
      pigs, rats, and mice) were sensitized for allergy such as eosinophilia and 
      leukocytosis induced by milk; degranulation of mast cell by compound 48/80; and 
      passive and active anaphylaxis. Moreover, the antagonistic effect was determined 
      by estimating the effect of corilagin on contraction of guinea pig tracheal chain 
      and ileum induced by Ach and histamine, respectively. RESULTS There was a 
      significant decrease in the leukocyte and eosinophil counts in the 
      corilagin-treated group compared to the negative control group. Treatment with 
      corilagin significantly protects the degranulation of mast cells, and it also has 
      significant anti-muscarinic and antihistaminic activity by reducing the muscle 
      contraction induced by Acetylcholine (Ach) and histamine in guinea pig tracheal 
      chain and ileum. CONCLUSIONS Corilagin possess anti-anaphylactic and 
      anti-allergic activity by inhibiting the release of mediators from mast cells and 
      by decreasing the serum concentration of immunoglobulin E (IgE).
FAU - Zhou, Jie
AU  - Zhou J
AD  - Department of Dermatology, Seventh People's Hospital of Shanghai University of 
      Traditional Chinese Medicine, Shanghai, China (mainland).
FAU - Zhang, Ci'an
AU  - Zhang C
AD  - Department of Traditional Chinese Medicine, Shanghai Changzheng Hospital, 
      Shanghai, China (mainland).
FAU - Sun, Yuanyuan
AU  - Sun Y
AD  - Department of Dermatology, Suzhou Municipal Hospital of Anhui Province, Suzhou, 
      Anhui, China (mainland).
FAU - Wang, Li
AU  - Wang L
AD  - Department of Dermatology, Seventh People's Hospital of Shanghai University of 
      Traditional Chinese Medicine, Shanghai, China (mainland).
FAU - Zhang, Jian
AU  - Zhang J
AD  - Department of Dermatology, Seventh People's Hospital of Shanghai University of 
      Traditional Chinese Medicine, Shanghai, China (mainland).
FAU - Li, Fulun
AU  - Li F
AD  - Department of Dermatology, Seventh People's Hospital of Shanghai University of 
      Traditional Chinese Medicine, Shanghai, China (mainland).
FAU - Mao, Weian
AU  - Mao W
AD  - Department of Dermatology, Seventh People's Hospital of Shanghai University of 
      Traditional Chinese Medicine, Shanghai, China (mainland).
LA  - eng
PT  - Journal Article
DEP - 20180213
PL  - United States
TA  - Med Sci Monit
JT  - Medical science monitor : international medical journal of experimental and 
      clinical research
JID - 9609063
RN  - 0 (Glucosides)
RN  - 0 (Hydrolyzable Tannins)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 62LOS9TW6D (corilagin)
RN  - 820484N8I3 (Histamine)
RN  - N9YNS0M02X (Acetylcholine)
SB  - IM
MH  - Acetylcholine/metabolism
MH  - Anaphylaxis/blood/*drug therapy/*pathology
MH  - Animals
MH  - *Cell Degranulation/drug effects
MH  - Edema/complications/drug therapy/pathology
MH  - Eosinophilia/blood/complications/drug therapy
MH  - Glucosides/pharmacology/*therapeutic use
MH  - Guinea Pigs
MH  - Histamine/metabolism
MH  - Hydrolyzable Tannins/pharmacology/*therapeutic use
MH  - Hypersensitivity/blood/*drug therapy/*pathology
MH  - Immunoglobulin E/blood
MH  - Inhibitory Concentration 50
MH  - Leukocytosis/blood/complications/drug therapy
MH  - Mast Cells/drug effects/*physiology
MH  - Mice
MH  - Milk/adverse effects
MH  - Rats, Sprague-Dawley
PMC - PMC5819305
COIS- Conflicts of interest None.
EDAT- 2018/02/13 06:00
MHDA- 2018/08/18 06:00
PMCR- 2018/02/13
CRDT- 2018/02/14 06:00
PHST- 2018/02/14 06:00 [entrez]
PHST- 2018/02/13 06:00 [pubmed]
PHST- 2018/08/18 06:00 [medline]
PHST- 2018/02/13 00:00 [pmc-release]
AID - 906098 [pii]
AID - 10.12659/msm.906098 [doi]
PST - epublish
SO  - Med Sci Monit. 2018 Feb 13;24:891-896. doi: 10.12659/msm.906098.