PMID- 29434343
OWN - NLM
STAT- MEDLINE
DCOM- 20190610
LR  - 20230210
IS  - 1530-0285 (Electronic)
IS  - 0893-3952 (Linking)
VI  - 31
IP  - 7
DP  - 2018 Jul
TI  - Differential expression patterns of GATA3 in usual and differentiated types of 
      vulvar intraepithelial neoplasia: potential diagnostic implications.
PG  - 1131-1140
LID - 10.1038/s41379-018-0021-y [doi]
AB  - The two main precursors of vulvar squamous cell carcinoma, usual and 
      differentiated vulvar intraepithelial neoplasia (VIN), have distinctive etiology, 
      pathogenesis, and natural history. Usual type VIN is often associated with 
      high-risk HPV and differentiated VIN has de novo p53 genetic alterations that are 
      unrelated to HPV infection. GATA-binding protein 3 (GATA3) is a tumor suppressor 
      that shows increased expression in several types of human malignancies including 
      breast and bladder carcinomas. Little is known regarding the expression of GATA3 
      in vulvar squamous neoplasms. We have systematically examined the expression of 
      GATA3 in 119 vulvar lesions and neoplasms including 20 cases of lichen sclerosus, 
      12 cases of lichen simplex chronicus, 30 cases of usual type VIN, 34 cases of 
      differentiated VIN, and 23 cases of squamous cell carcinoma. Similar to adjacent 
      non-neoplastic epidermis, moderate to strong GATA3 expression was retained in all 
      cases of lichen sclerosus, lichen simplex chronicus, and usual type VIN. However, 
      in comparison, the GATA3 immunostaining pattern in differentiated VIN was 
      distinct. Partial/complete loss of GATA3 expression in the basal layer with or 
      without loss in the parabasal layer was observed in 30/34 (88%) of differentiated 
      VIN cases. Significant loss of GATA3 expression was also observed in all (7/7) 
      squamous cell carcinomas associated with usual type VIN and in 13/16 (81%) of 
      those associated with differentiated VIN. There was no significant correlation 
      between loss of GATA3 expression and overexpression of p53 in differentiated VIN. 
      Our study shows that loss of GATA3 expression is seen in the vast majority (87%) 
      of vulvar squamous cell carcinomas. Downregulation of GATA3 may be an early event 
      during tumorigenesis in differentiated VIN but not in HPV-related usual type VIN. 
      Our data suggests that application of GATA3 immunohistochemistry along with p53 
      may be a useful tool in facilitating the accurate diagnosis of VIN.
FAU - Goyal, Abha
AU  - Goyal A
AD  - Weill Cornell Medicine, New York Presbyterian Hospital, 525 East 68th Street, 
      F766, New York, NY, 10065, USA.
FAU - Zhang, Gloria
AU  - Zhang G
AD  - Department of Pathology, Robert J. Tomsich Pathology and Laboratory Medicine 
      Institute, Cleveland Clinic, 9500 Euclid Avenue, L25, Cleveland, OH, 44195, USA.
FAU - Yang, Bin
AU  - Yang B
AD  - Department of Pathology, Robert J. Tomsich Pathology and Laboratory Medicine 
      Institute, Cleveland Clinic, 9500 Euclid Avenue, L25, Cleveland, OH, 44195, USA. 
      yangb@ccf.org.
LA  - eng
PT  - Journal Article
DEP - 20180213
PL  - United States
TA  - Mod Pathol
JT  - Modern pathology : an official journal of the United States and Canadian Academy 
      of Pathology, Inc
JID - 8806605
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (GATA3 Transcription Factor)
RN  - 0 (GATA3 protein, human)
SB  - IM
MH  - Biomarkers, Tumor/analysis
MH  - Carcinoma in Situ/*diagnosis/metabolism/pathology
MH  - Carcinoma, Squamous Cell/*diagnosis/metabolism/pathology
MH  - Female
MH  - GATA3 Transcription Factor/*biosynthesis
MH  - Humans
MH  - Middle Aged
MH  - Vulvar Neoplasms/*diagnosis/metabolism/pathology
EDAT- 2018/02/13 06:00
MHDA- 2019/06/14 06:00
CRDT- 2018/02/14 06:00
PHST- 2017/10/31 00:00 [received]
PHST- 2017/12/21 00:00 [accepted]
PHST- 2017/12/20 00:00 [revised]
PHST- 2018/02/13 06:00 [pubmed]
PHST- 2019/06/14 06:00 [medline]
PHST- 2018/02/14 06:00 [entrez]
AID - S0893-3952(22)01697-0 [pii]
AID - 10.1038/s41379-018-0021-y [doi]
PST - ppublish
SO  - Mod Pathol. 2018 Jul;31(7):1131-1140. doi: 10.1038/s41379-018-0021-y. Epub 2018 
      Feb 13.