PMID- 29434771
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 15
IP  - 2
DP  - 2018 Feb
TI  - Adeno-associated virus serotype 9 mediated vascular endothelial growth factor 
      gene overexpression in mdx mice.
PG  - 1825-1830
LID - 10.3892/etm.2017.5610 [doi]
AB  - Duchenne muscular dystrophy (DMD) is a fatal neuromuscular disease caused by the 
      absence of dystrophin. Vascular endothelial growth factor (VEGF) is a 
      heparin-binding dimeric glycoprotein and principal angiogenic factor stimulating 
      the migration, proliferation and expression of various genes in endothelial 
      cells. Recently, VEGF was demonstrated to exhibit an antiapoptotic and direct 
      myogenic effect, as well as to enhance muscle force restoration subsequent to 
      traumatic injury. Therefore, the present study attempted to assess the muscle 
      damage of VEGF overexpression in mdx mice. Adeno-associated virus serotype 9 
      (AAV9)-VEGF was administered intravenously to mdx mice. At 4 weeks after 
      injection, VEGF was observed to be upregulated in the tibialis anterior muscle. 
      In addition, the serum creatine kinase levels were significantly reduced and 
      fatigue was slowed down, whereas the limb grip strength and weight of mice were 
      markedly increased compared with the saline-treated mdx mice. Furthermore, 
      significantly reduced inflammation and necrosis areas were observed in the muscle 
      tissues of mice in the AAV9-VEGF group. These results suggested that 
      AAV9-mediated VEGF gene overexpression was able to improve the muscle damage in 
      mdx mice.
FAU - Song, Xueqin
AU  - Song X
AD  - Department of Neurology, The Second Hospital of Hebei Medical University, 
      Shijiazhuang, Hebei 050000, P.R. China.
AD  - Institute of Cardiocerebrovascular Disease, Shijiazhuang, Hebei 050000, P.R. 
      China.
AD  - Neurological Laboratory of Hebei, Shijiazhuang, Hebei 050000, P.R. China.
FAU - Zhang, Ya
AU  - Zhang Y
AD  - Department of Neurology, The Second Hospital of Hebei Medical University, 
      Shijiazhuang, Hebei 050000, P.R. China.
FAU - Hou, Zhigang
AU  - Hou Z
AD  - Department of Neurology, The Second Hospital of Hebei Medical University, 
      Shijiazhuang, Hebei 050000, P.R. China.
FAU - Wu, Hongran
AU  - Wu H
AD  - Department of Neurology, The Second Hospital of Hebei Medical University, 
      Shijiazhuang, Hebei 050000, P.R. China.
AD  - Neurological Laboratory of Hebei, Shijiazhuang, Hebei 050000, P.R. China.
FAU - Lu, Shan
AU  - Lu S
AD  - Department of Neurology, The Second Hospital of Hebei Medical University, 
      Shijiazhuang, Hebei 050000, P.R. China.
FAU - Tang, Jin
AU  - Tang J
AD  - Department of Neurology, The Second Hospital of Hebei Medical University, 
      Shijiazhuang, Hebei 050000, P.R. China.
FAU - Chen, Xuexiao
AU  - Chen X
AD  - Department of Neurology, The Second Hospital of Hebei Medical University, 
      Shijiazhuang, Hebei 050000, P.R. China.
FAU - Cui, Hongying
AU  - Cui H
AD  - Department of Neurology, The Second Hospital of Hebei Medical University, 
      Shijiazhuang, Hebei 050000, P.R. China.
FAU - Li, Yuan
AU  - Li Y
AD  - Department of Neurology, The Second Hospital of Hebei Medical University, 
      Shijiazhuang, Hebei 050000, P.R. China.
FAU - Bi, Yue
AU  - Bi Y
AD  - Department of Neurology, The Second Hospital of Hebei Medical University, 
      Shijiazhuang, Hebei 050000, P.R. China.
AD  - Neurological Laboratory of Hebei, Shijiazhuang, Hebei 050000, P.R. China.
FAU - Duan, Weisong
AU  - Duan W
AD  - Neurological Laboratory of Hebei, Shijiazhuang, Hebei 050000, P.R. China.
FAU - Li, Zhongyao
AU  - Li Z
AD  - Neurological Laboratory of Hebei, Shijiazhuang, Hebei 050000, P.R. China.
FAU - Li, Chunyan
AU  - Li C
AD  - Department of Neurology, The Second Hospital of Hebei Medical University, 
      Shijiazhuang, Hebei 050000, P.R. China.
AD  - Institute of Cardiocerebrovascular Disease, Shijiazhuang, Hebei 050000, P.R. 
      China.
AD  - Neurological Laboratory of Hebei, Shijiazhuang, Hebei 050000, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20171211
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC5776553
OTO - NOTNLM
OT  - adeno-associated virus 9
OT  - creatine kinase
OT  - duchenne muscular dystrophy
OT  - mdx mice
OT  - muscle force
OT  - muscle pathology
OT  - vascular endothelial growth factor
EDAT- 2018/02/13 06:00
MHDA- 2018/02/13 06:01
PMCR- 2017/12/11
CRDT- 2018/02/14 06:00
PHST- 2016/09/09 00:00 [received]
PHST- 2017/09/13 00:00 [accepted]
PHST- 2018/02/14 06:00 [entrez]
PHST- 2018/02/13 06:00 [pubmed]
PHST- 2018/02/13 06:01 [medline]
PHST- 2017/12/11 00:00 [pmc-release]
AID - ETM-0-0-5610 [pii]
AID - 10.3892/etm.2017.5610 [doi]
PST - ppublish
SO  - Exp Ther Med. 2018 Feb;15(2):1825-1830. doi: 10.3892/etm.2017.5610. Epub 2017 Dec 
      11.