PMID- 29434854
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1792-1074 (Print)
IS  - 1792-1082 (Electronic)
IS  - 1792-1074 (Linking)
VI  - 15
IP  - 2
DP  - 2018 Feb
TI  - Celastrus orbiculatus extracts induce cell cycle arrest and apoptosis in human 
      esophageal squamous carcinoma ECA-109 cells in vitro via the PI3K/AKT/mTOR 
      signaling pathway.
PG  - 1591-1599
LID - 10.3892/ol.2017.7459 [doi]
AB  - Recently, Celastrus orbiculatus ethyl acetate extracts (COE) have been 
      investigated for their anticancer effects on digestive tract tumors. However, the 
      therapeutic effects of COE on esophageal squamous carcinoma cells (ESCC) have not 
      been investigated. In the present study, the effects of COE on the cell cycle and 
      apoptosis of ESCCs were assessed in vitro, and it was revealed that COE treatment 
      triggered G(0)/G(1) cell cycle arrest, and induced DNA damage and apoptosis in a 
      dose-dependent manner in ESCC. Activation of the phosphatidylinositol 
      3-kinase/protein kinase-B/mechanistic target of rapamycin (mTOR) pathway was also 
      suppressed by COE. Additionally, the combined treatment with COE and rapamycin 
      (an mTOR inhibitor) acted synergistically in ECA-109 cells compared with the 
      treatment with COE or rapamycin alone. These findings extend the understanding of 
      the action of COE and suggest that COE has potential as a treatment option for 
      ESCC as a single treatment or in combination.
FAU - Jin, Feng
AU  - Jin F
AD  - Institute of Traditional Chinese Medicine and Western Medicine, School of 
      Medicine, Yangzhou University, Yangzhou, Jiangsu 225009, P.R. China.
FAU - Zhu, Guang
AU  - Zhu G
AD  - Institute of Traditional Chinese Medicine and Western Medicine, School of 
      Medicine, Yangzhou University, Yangzhou, Jiangsu 225009, P.R. China.
FAU - Li, Dan
AU  - Li D
AD  - Institute of Traditional Chinese Medicine and Western Medicine, School of 
      Medicine, Yangzhou University, Yangzhou, Jiangsu 225009, P.R. China.
FAU - Ni, Tengyang
AU  - Ni T
AD  - Institute of Traditional Chinese Medicine and Western Medicine, School of 
      Medicine, Yangzhou University, Yangzhou, Jiangsu 225009, P.R. China.
FAU - Dai, Xiaojun
AU  - Dai X
AD  - Institute of Traditional Chinese Medicine and Western Medicine, School of 
      Medicine, Yangzhou University, Yangzhou, Jiangsu 225009, P.R. China.
AD  - Department of Oncology, Yangzhou Hospital of Traditional Chinese Medicine, 
      Yangzhou, Jiangsu 225009, P.R. China.
FAU - Wang, Haibo
AU  - Wang H
AD  - Institute of Traditional Chinese Medicine and Western Medicine, School of 
      Medicine, Yangzhou University, Yangzhou, Jiangsu 225009, P.R. China.
FAU - Feng, Jun
AU  - Feng J
AD  - Institute of Traditional Chinese Medicine and Western Medicine, School of 
      Medicine, Yangzhou University, Yangzhou, Jiangsu 225009, P.R. China.
FAU - Qian, Yayun
AU  - Qian Y
AD  - Institute of Traditional Chinese Medicine and Western Medicine, School of 
      Medicine, Yangzhou University, Yangzhou, Jiangsu 225009, P.R. China.
FAU - Yang, Lin
AU  - Yang L
AD  - Institute of Traditional Chinese Medicine and Western Medicine, School of 
      Medicine, Yangzhou University, Yangzhou, Jiangsu 225009, P.R. China.
FAU - Guo, Shiyu
AU  - Guo S
AD  - Department of Physiology, Showa University, Tokyo 142-8555, Japan.
FAU - Hisamitsu, Tadashi
AU  - Hisamitsu T
AD  - Department of Physiology, Showa University, Tokyo 142-8555, Japan.
FAU - Liu, Yanqing
AU  - Liu Y
AD  - Institute of Traditional Chinese Medicine and Western Medicine, School of 
      Medicine, Yangzhou University, Yangzhou, Jiangsu 225009, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20171121
PL  - Greece
TA  - Oncol Lett
JT  - Oncology letters
JID - 101531236
PMC - PMC5774469
OTO - NOTNLM
OT  - Celastrus orbiculatus
OT  - apoptosis
OT  - cell cycle
OT  - esophageal squamous carcinoma cells
OT  - phosphoinositide-3 kinase/protein kinase B/mechanistic target of rapamycin 
      signaling pathway
EDAT- 2018/02/13 06:00
MHDA- 2018/02/13 06:01
PMCR- 2017/11/21
CRDT- 2018/02/14 06:00
PHST- 2016/04/12 00:00 [received]
PHST- 2017/07/11 00:00 [accepted]
PHST- 2018/02/14 06:00 [entrez]
PHST- 2018/02/13 06:00 [pubmed]
PHST- 2018/02/13 06:01 [medline]
PHST- 2017/11/21 00:00 [pmc-release]
AID - OL-0-0-7459 [pii]
AID - 10.3892/ol.2017.7459 [doi]
PST - ppublish
SO  - Oncol Lett. 2018 Feb;15(2):1591-1599. doi: 10.3892/ol.2017.7459. Epub 2017 Nov 
      21.