PMID- 29435455
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2297-1769 (Print)
IS  - 2297-1769 (Electronic)
IS  - 2297-1769 (Linking)
VI  - 5
DP  - 2018
TI  - Estimating Parameters Related to the Lifespan of Passively Transferred and 
      Vaccine-Induced Porcine Reproductive and Respiratory Syndrome Virus Type I 
      Antibodies by Modeling Field Data.
PG  - 9
LID - 10.3389/fvets.2018.00009 [doi]
LID - 9
AB  - The outputs of epidemiological models are strongly related to the structure of 
      the model and input parameters. The latter are defined by fitting theoretical 
      concepts to actual data derived from field or experimental studies. However, some 
      parameters may remain difficult to estimate and are subject to uncertainty or 
      sensitivity analyses to determine their variation range and their global impact 
      on model outcomes. As such, the evaluation of immunity duration is often a 
      puzzling issue requiring long-term follow-up data that are, most of time, not 
      available. The present analysis aims at characterizing the kinetics of antibodies 
      against Porcine Reproductive and Respiratory Syndrome virus (PRRSv) from 
      longitudinal data sets. The first data set consisted in the serological follow-up 
      of 22 vaccinated gilts during 21 weeks post-vaccination (PV). The second one 
      gathered the maternally derived antibodies (MDAs) kinetics in piglets from three 
      different farms up to 14 weeks of age. The peak of the PV serological response 
      against PRRSv was reached 6.9 weeks PV on average with an average duration of 
      antibodies persistence of 26.5 weeks. In the monitored cohort of piglets, the 
      duration of passive immunity was found relatively short, with an average duration 
      of 4.8 weeks. The level of PRRSv-MDAs was found correlated with the dams' 
      antibody titer at birth, and the antibody persistence was strongly related to the 
      initial MDAs titers in piglets. These results evidenced the importance of PRRSv 
      vaccination schedule in sows, to optimize the delivery of antibodies to suckling 
      piglets. These estimates of the duration of active and passive immunity could be 
      further used as input parameters of epidemiological models to analyze their 
      impact on the persistence of PRRSv within farms.
FAU - Andraud, Mathieu
AU  - Andraud M
AD  - Unite epidemiologie et bien-etre du porc, Anses Laboratoire de 
      Ploufragan-Plouzane, Ploufragan, France.
AD  - Universite Bretagne-Loire, Rennes, France.
FAU - Fablet, Christelle
AU  - Fablet C
AD  - Unite epidemiologie et bien-etre du porc, Anses Laboratoire de 
      Ploufragan-Plouzane, Ploufragan, France.
AD  - Universite Bretagne-Loire, Rennes, France.
FAU - Renson, Patricia
AU  - Renson P
AD  - Universite Bretagne-Loire, Rennes, France.
AD  - Unite Virologie Immunologie Porcines, Anses Laboratoire de Ploufragan-Plouzane, 
      Ploufragan, France.
AD  - Union des Groupements de Producteurs de Viande de Bretagne (UGPVB), Rennes, 
      France.
FAU - Eono, Florent
AU  - Eono F
AD  - Unite epidemiologie et bien-etre du porc, Anses Laboratoire de 
      Ploufragan-Plouzane, Ploufragan, France.
AD  - Universite Bretagne-Loire, Rennes, France.
FAU - Mahe, Sophie
AU  - Mahe S
AD  - Universite Bretagne-Loire, Rennes, France.
AD  - Unite Virologie Immunologie Porcines, Anses Laboratoire de Ploufragan-Plouzane, 
      Ploufragan, France.
FAU - Bourry, Olivier
AU  - Bourry O
AD  - Universite Bretagne-Loire, Rennes, France.
AD  - Unite Virologie Immunologie Porcines, Anses Laboratoire de Ploufragan-Plouzane, 
      Ploufragan, France.
FAU - Rose, Nicolas
AU  - Rose N
AD  - Unite epidemiologie et bien-etre du porc, Anses Laboratoire de 
      Ploufragan-Plouzane, Ploufragan, France.
AD  - Universite Bretagne-Loire, Rennes, France.
LA  - eng
PT  - Journal Article
DEP - 20180129
PL  - Switzerland
TA  - Front Vet Sci
JT  - Frontiers in veterinary science
JID - 101666658
PMC - PMC5796902
OTO - NOTNLM
OT  - antibody kinetics
OT  - maternally derived antibodies
OT  - parameter estimation
OT  - porcine reproductive and respiratory syndrome
OT  - vaccine-induced immunity
EDAT- 2018/02/13 06:00
MHDA- 2018/02/13 06:01
PMCR- 2018/01/01
CRDT- 2018/02/14 06:00
PHST- 2017/11/21 00:00 [received]
PHST- 2018/01/12 00:00 [accepted]
PHST- 2018/02/14 06:00 [entrez]
PHST- 2018/02/13 06:00 [pubmed]
PHST- 2018/02/13 06:01 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - 10.3389/fvets.2018.00009 [doi]
PST - epublish
SO  - Front Vet Sci. 2018 Jan 29;5:9. doi: 10.3389/fvets.2018.00009. eCollection 2018.