PMID- 29435789
OWN - NLM
STAT- MEDLINE
DCOM- 20190118
LR  - 20220408
IS  - 1546-9549 (Electronic)
IS  - 1546-9530 (Print)
IS  - 1546-9530 (Linking)
VI  - 15
IP  - 2
DP  - 2018 Apr
TI  - Chronic Right Ventricular Pacing in the Heart Failure Population.
PG  - 61-69
LID - 10.1007/s11897-018-0376-x [doi]
AB  - PURPOSE OF REVIEW: We review the trials that have demonstrated potentially 
      harmful effects from right ventricular (RV) apical pacing as well as reviewing 
      the evidence of alternative RV pacing sites and cardiac resynchronization therapy 
      (CRT) for patients who have heart failure and atrioventricular (AV) block. RECENT 
      FINDINGS: The role of CRT in patients with AV block and impaired left ventricular 
      function remains an important consideration. The BLOCK HF trial demonstrated 
      better outcomes with CRT pacing over RV pacing in patients with left ventricular 
      systolic dysfunction (LVSD) and AV block who were expected to have a high RV 
      pacing burden, but failed to demonstrate a mortality benefit. CRT seems to have a 
      beneficial effect on left ventricular reverse remodeling, systolic function, and 
      clinical outcomes in patients with New York Heart Association (NYHA) functional 
      class I-III heart failure, moderate to severe LVSD, and AV block compared to RV 
      pacing. However, it is less clear whether there is a similar benefit from CRT in 
      patients with a high percentage of RV pacing who have normal or mild LVSD in the 
      treatment of AV block.
FAU - Gould, Justin
AU  - Gould J
AD  - King's College London, London, UK. justin.s.gould@kcl.ac.uk.
AD  - Guy's and St Thomas' NHS Foundation Trust, London, UK. justin.s.gould@kcl.ac.uk.
FAU - Sieniewicz, Benjamin
AU  - Sieniewicz B
AD  - King's College London, London, UK.
AD  - Guy's and St Thomas' NHS Foundation Trust, London, UK.
FAU - Porter, Bradley
AU  - Porter B
AD  - King's College London, London, UK.
AD  - Guy's and St Thomas' NHS Foundation Trust, London, UK.
FAU - Sidhu, Baldeep
AU  - Sidhu B
AD  - King's College London, London, UK.
AD  - Guy's and St Thomas' NHS Foundation Trust, London, UK.
FAU - Rinaldi, Christopher A
AU  - Rinaldi CA
AD  - King's College London, London, UK.
AD  - Guy's and St Thomas' NHS Foundation Trust, London, UK.
LA  - eng
GR  - PG/16/108/32593/BHF_/British Heart Foundation/United Kingdom
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Heart Fail Rep
JT  - Current heart failure reports
JID - 101196487
SB  - IM
MH  - Cardiac Pacing, Artificial/*methods
MH  - Heart Conduction System/*physiopathology
MH  - Heart Failure/physiopathology/*therapy
MH  - Humans
MH  - Treatment Outcome
MH  - Ventricular Function, Left/*physiology
MH  - Ventricular Remodeling/*physiology
PMC - PMC5857555
OTO - NOTNLM
OT  - Biventricular
OT  - CRT
OT  - Cardiac resynchronization therapy
OT  - Chronic right ventricular pacing
OT  - Heart failure
COIS- CONFLICT OF INTEREST: Justin Gould and Bradley Porter are on clinical research 
      fellowship programs funded by Abbott. Baldeep Sidhu is on a clinical research 
      fellowship program funded by Medtronic Inc. Christopher A. Rinaldi receives 
      research funding and/or consultancy fees from Abbott, Medtronic Inc., Boston, and 
      LivaNova outside of the submitted work. HUMAN AND ANIMAL RIGHTS AND INFORMED 
      CONSENT: This article does not contain any studies with human or animal subjects 
      performed by any of the authors.
EDAT- 2018/02/13 06:00
MHDA- 2019/01/19 06:00
PMCR- 2018/02/12
CRDT- 2018/02/14 06:00
PHST- 2018/02/13 06:00 [pubmed]
PHST- 2019/01/19 06:00 [medline]
PHST- 2018/02/14 06:00 [entrez]
PHST- 2018/02/12 00:00 [pmc-release]
AID - 10.1007/s11897-018-0376-x [pii]
AID - 376 [pii]
AID - 10.1007/s11897-018-0376-x [doi]
PST - ppublish
SO  - Curr Heart Fail Rep. 2018 Apr;15(2):61-69. doi: 10.1007/s11897-018-0376-x.