PMID- 29436218
OWN - NLM
STAT- MEDLINE
DCOM- 20190211
LR  - 20220129
IS  - 1520-5010 (Electronic)
IS  - 0893-228X (Linking)
VI  - 31
IP  - 3
DP  - 2018 Mar 19
TI  - Application of in Vitro T Cell Assay Using Human Leukocyte Antigen-Typed Healthy 
      Donors for the Assessment of Drug Immunogenicity.
PG  - 165-167
LID - 10.1021/acs.chemrestox.8b00030 [doi]
AB  - It is unclear whether priming of naive T cells to drugs is detectable in healthy 
      human donors expressing different human leukocyte antigen (HLA) alleles. Thus, we 
      examined T cell priming with drugs associated with HLA risk alleles and control 
      compounds in 14 HLA-typed donors. Nitroso sulfamethoxazole and piperacillin 
      activated T cells from all donors, whereas responses to carbamazepine and 
      oxypurinol were only seen in donors expressing HLA-B*15:02 and HLA-B*58:01, 
      respectively. Weak flucloxacillin-specific T cell responses were detected in 
      donors expressing HLA-B*57:01 and HLA-B*58:01. These data show that the priming 
      of T cells with certain drugs is skewed toward donors expressing specific HLA 
      alleles.
FAU - Usui, Toru
AU  - Usui T
AD  - MRC Centre for Drug Safety Science, Department of Molecular and Clinical 
      Pharmacology , University of Liverpool , Sherrington Building, Ashton Street , 
      Liverpool L69 3GE , England.
FAU - Faulkner, Lee
AU  - Faulkner L
AD  - MRC Centre for Drug Safety Science, Department of Molecular and Clinical 
      Pharmacology , University of Liverpool , Sherrington Building, Ashton Street , 
      Liverpool L69 3GE , England.
FAU - Farrell, John
AU  - Farrell J
AD  - MRC Centre for Drug Safety Science, Department of Molecular and Clinical 
      Pharmacology , University of Liverpool , Sherrington Building, Ashton Street , 
      Liverpool L69 3GE , England.
FAU - French, Neil S
AU  - French NS
AD  - MRC Centre for Drug Safety Science, Department of Molecular and Clinical 
      Pharmacology , University of Liverpool , Sherrington Building, Ashton Street , 
      Liverpool L69 3GE , England.
FAU - Alfirevic, Ana
AU  - Alfirevic A
AD  - MRC Centre for Drug Safety Science, Department of Molecular and Clinical 
      Pharmacology , University of Liverpool , Sherrington Building, Ashton Street , 
      Liverpool L69 3GE , England.
FAU - Pirmohamed, Munir
AU  - Pirmohamed M
AD  - MRC Centre for Drug Safety Science, Department of Molecular and Clinical 
      Pharmacology , University of Liverpool , Sherrington Building, Ashton Street , 
      Liverpool L69 3GE , England.
FAU - Park, B Kevin
AU  - Park BK
AD  - MRC Centre for Drug Safety Science, Department of Molecular and Clinical 
      Pharmacology , University of Liverpool , Sherrington Building, Ashton Street , 
      Liverpool L69 3GE , England.
FAU - Naisbitt, Dean J
AU  - Naisbitt DJ
AUID- ORCID: 0000-0003-4107-7832
AD  - MRC Centre for Drug Safety Science, Department of Molecular and Clinical 
      Pharmacology , University of Liverpool , Sherrington Building, Ashton Street , 
      Liverpool L69 3GE , England.
LA  - eng
GR  - G0700654/MRC_/Medical Research Council/United Kingdom
GR  - MR/L006758/1/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180214
PL  - United States
TA  - Chem Res Toxicol
JT  - Chemical research in toxicology
JID - 8807448
RN  - 0 (Anti-Infective Agents)
RN  - 0 (Anticonvulsants)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (Nitroso Compounds)
RN  - 33CM23913M (Carbamazepine)
RN  - G97OZE5068 (Oxypurinol)
RN  - JE42381TNV (Sulfamethoxazole)
RN  - X00B0D5O0E (Piperacillin)
SB  - IM
MH  - Anti-Infective Agents/adverse effects/immunology
MH  - Anticonvulsants/adverse effects/immunology
MH  - Carbamazepine/adverse effects/immunology
MH  - Drug-Related Side Effects and Adverse Reactions/*immunology
MH  - Enzyme Inhibitors/adverse effects/immunology
MH  - HLA Antigens/*immunology
MH  - HLA-B Antigens/immunology
MH  - Humans
MH  - Lymphocyte Activation/*drug effects
MH  - Nitroso Compounds/adverse effects/immunology
MH  - Oxypurinol/adverse effects/immunology
MH  - Piperacillin/adverse effects/immunology
MH  - Sulfamethoxazole/adverse effects/immunology
MH  - T-Lymphocytes/*drug effects/immunology
EDAT- 2018/02/14 06:00
MHDA- 2019/02/12 06:00
CRDT- 2018/02/14 06:00
PHST- 2018/02/14 06:00 [pubmed]
PHST- 2019/02/12 06:00 [medline]
PHST- 2018/02/14 06:00 [entrez]
AID - 10.1021/acs.chemrestox.8b00030 [doi]
PST - ppublish
SO  - Chem Res Toxicol. 2018 Mar 19;31(3):165-167. doi: 10.1021/acs.chemrestox.8b00030. 
      Epub 2018 Feb 14.