PMID- 29436655
OWN - NLM
STAT- MEDLINE
DCOM- 20180830
LR  - 20211111
IS  - 1791-3004 (Electronic)
IS  - 1791-2997 (Linking)
VI  - 17
IP  - 4
DP  - 2018 Apr
TI  - Effects of dexmedetomidine post‑treatment on BDNF and VEGF expression following 
      cerebral ischemia/reperfusion injury in rats.
PG  - 6033-6037
LID - 10.3892/mmr.2018.8597 [doi]
AB  - Brain‑derived neurotrophic factor (BDNF) and vascular endothelial growth factor 
      (VEGF) serves a significant role in neural protection by activating the 
      phosphatidylinositol 3‑kinase (PI3K)/Akt signaling pathway, which also was 
      associated with the neuroprotective the treatment with dexmedetomidine (DEX). The 
      present study aimed to further explore whether treatment with DEX post‑IR 
      increased the expression level of BDNF and VEGF in the rat brain. A total of 30 
      healthy, clean male Wistar rats were randomly divided into 3 experimental groups: 
      Control group, ischemia/reperfusion (I/R) group and DEX treatment group. 
      Subsequently, BDNF and VEGF mRNA and protein expression levels were analyzed. The 
      results indicated that the mRNA expression levels of BDNF and VEGF were higher in 
      the I/R and DEX groups compared with expression levels in the Control group at 
      6 h and 1 day post‑treatment; the levels of BNDF mRNA expression were higher in 
      the DEX group compared with the I/R group. The levels of BDNF and VEGF protein 
      expression in the I/R and DEX groups were also significantly higher compared with 
      those in the Control group. I/R surgery significantly increased the expression of 
      BDNF and VEGF protein DEX group at 6 h, day 1 and day 3 compared with expression 
      levels in the I/R group. Results from the present study indicated that 
      post‑surgical treatment with DEX may increase the expression of BDNF and VEGF 
      following I/R, which may serve a role in nerve protection.
FAU - Li, Zheng-Chen
AU  - Li ZC
AD  - Department of Anesthesia, The First Affiliated Hospital of Zhengzhou University, 
      Zhengzhou, Henan 450052, P.R. China.
FAU - Jia, Ying-Ping
AU  - Jia YP
AD  - Department of Anesthesia, Zhengzhou Children's Hospital, Zhengzhou, Henan 450053, 
      P.R. China.
FAU - Wang, Yuan
AU  - Wang Y
AD  - Department of Anesthesia, Zhengzhou Children's Hospital, Zhengzhou, Henan 450053, 
      P.R. China.
FAU - Qi, Jin-Lian
AU  - Qi JL
AD  - Department of Anesthesia, Zhengzhou Children's Hospital, Zhengzhou, Henan 450053, 
      P.R. China.
FAU - Han, Xue-Ping
AU  - Han XP
AD  - Department of Anesthesia, The First Affiliated Hospital of Zhengzhou University, 
      Zhengzhou, Henan 450052, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20180213
PL  - Greece
TA  - Mol Med Rep
JT  - Molecular medicine reports
JID - 101475259
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 67VB76HONO (Dexmedetomidine)
SB  - IM
MH  - Animals
MH  - Brain Ischemia/*genetics/metabolism/pathology
MH  - Brain-Derived Neurotrophic Factor/*genetics/metabolism
MH  - Cell Line
MH  - Dexmedetomidine/*pharmacology
MH  - Gene Expression Regulation/*drug effects
MH  - Male
MH  - RNA, Messenger/genetics/metabolism
MH  - Rats
MH  - Reperfusion Injury/drug therapy/*genetics/metabolism/pathology
MH  - Vascular Endothelial Growth Factor A/*genetics/metabolism
OTO - NOTNLM
OT  - dexmedetomidine
OT  - brain-derived neurotrophic factor
OT  - vascular endothelial growth factor
OT  - cerebral ischemia-reperfusion
EDAT- 2018/02/14 06:00
MHDA- 2018/08/31 06:00
CRDT- 2018/02/14 06:00
PHST- 2016/08/18 00:00 [received]
PHST- 2017/10/25 00:00 [accepted]
PHST- 2018/02/14 06:00 [pubmed]
PHST- 2018/08/31 06:00 [medline]
PHST- 2018/02/14 06:00 [entrez]
AID - 10.3892/mmr.2018.8597 [doi]
PST - ppublish
SO  - Mol Med Rep. 2018 Apr;17(4):6033-6037. doi: 10.3892/mmr.2018.8597. Epub 2018 Feb 
      13.