PMID- 29437822
OWN - NLM
STAT- MEDLINE
DCOM- 20180719
LR  - 20221207
IS  - 1935-5548 (Electronic)
IS  - 0149-5992 (Linking)
VI  - 41
IP  - 4
DP  - 2018 Apr
TI  - Elevated Serum Xanthine Oxidase Activity Is Associated With the Development of 
      Type 2 Diabetes: A Prospective Cohort Study.
PG  - 884-890
LID - 10.2337/dc17-1434 [doi]
AB  - OBJECTIVE: We aimed to evaluate whether xanthine oxidase (XO), a key enzyme in 
      uric acid (UA) metabolism and a major source of reactive oxygen species, plays a 
      causal and important role in the development of type 2 diabetes mellitus (T2DM) 
      in a large prospective cohort study. RESEARCH DESIGN AND METHODS: A total of 
      4,412 diabetes-free adults (2,071 women and 2,341 men) aged 30-65 years at 
      baseline in 2008 were involved. Participants were followed for incident change of 
      glucose metabolism during an average of 4.7 years. At baseline, serum XO and UA, 
      serum lipids, and glucose homeostasis indexes including fasting blood glucose 
      (FBG), 2-h blood glucose (PBG), glycosylated hemoglobin A(1c) (HbA(1c)), and 
      fasting insulin were tested for analysis. RESULTS: During an average follow-up 
      period of 4.7 years, 249 women and 360 men developed new-onset T2DM. Serum XO 
      activity was positively associated with UA concentration (all P values <0.001). 
      When XO activity and UA concentration were considered in the same model of the 
      sex-specific analysis, only XO activity was significantly associated with the 
      incidence of T2DM, with the hazard ratios from the bottom to the top quartile of 
      XO activity being 1.00, 1.67 (95% CI 1.00-2.79), 1.86 (1.11-3.13), and 2.36 
      (1.43-3.90) in women and 1.00, 1.01 (0.68-1.52), 1.41 (0.98-2.03), and 1.90 
      (1.30-2.78) in men. CONCLUSIONS: Elevated serum XO activity, but not UA 
      concentration, was associated with an increased risk of developing T2DM in women 
      and men with mutual adjustment for XO and UA. Further studies are needed to 
      examine the underlying mechanisms.
CI  - (c) 2018 by the American Diabetes Association.
FAU - Li, Xue
AU  - Li X
AUID- ORCID: 0000-0003-1585-4888
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Shanghai 
      Jiao Tong University School of Medicine, Shanghai, China.
AD  - Department of Nutrition and Food Hygiene, College of Public Health, Harbin 
      Medical University, Harbin, China.
FAU - Meng, Xing
AU  - Meng X
AD  - Department of Nutrition and Food Hygiene, College of Public Health, Harbin 
      Medical University, Harbin, China.
FAU - Gao, Xiangchun
AU  - Gao X
AD  - Fourth Affiliated Hospital, Harbin Medical University, Harbin, China.
FAU - Pang, Xiuyu
AU  - Pang X
AD  - Department of Nutrition and Food Hygiene, College of Public Health, Harbin 
      Medical University, Harbin, China.
FAU - Wang, Yanjiao
AU  - Wang Y
AD  - Department of Nutrition and Food Hygiene, College of Public Health, Harbin 
      Medical University, Harbin, China.
FAU - Wu, Xiaoyan
AU  - Wu X
AD  - Department of Nutrition and Food Hygiene, College of Public Health, Harbin 
      Medical University, Harbin, China.
FAU - Deng, Xinrui
AU  - Deng X
AD  - Department of Nutrition and Food Hygiene, College of Public Health, Harbin 
      Medical University, Harbin, China.
FAU - Zhang, Qiao
AU  - Zhang Q
AD  - Department of Nutrition and Food Hygiene, College of Public Health, Harbin 
      Medical University, Harbin, China.
FAU - Sun, Changhao
AU  - Sun C
AD  - Department of Nutrition and Food Hygiene, College of Public Health, Harbin 
      Medical University, Harbin, China liying_helen@163.com changhaosun2002@163.com.
FAU - Li, Ying
AU  - Li Y
AD  - Department of Nutrition and Food Hygiene, College of Public Health, Harbin 
      Medical University, Harbin, China liying_helen@163.com changhaosun2002@163.com.
LA  - eng
SI  - ChiCTR/ChiCTR-ECH-12002938
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20180202
PL  - United States
TA  - Diabetes Care
JT  - Diabetes care
JID - 7805975
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Insulin)
RN  - 0 (Triglycerides)
RN  - 268B43MJ25 (Uric Acid)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - EC 1.17.3.2 (Xanthine Oxidase)
SB  - IM
EIN - Diabetes Care. 2019 Mar;42(3):494. PMID: 30674548
MH  - Adult
MH  - Aged
MH  - Blood Glucose/metabolism
MH  - Body Mass Index
MH  - Cholesterol/blood
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*blood/*epidemiology
MH  - Exercise
MH  - Female
MH  - Glycated Hemoglobin/metabolism
MH  - Humans
MH  - Incidence
MH  - Insulin/blood
MH  - Male
MH  - Middle Aged
MH  - Proportional Hazards Models
MH  - Prospective Studies
MH  - Sex Factors
MH  - Triglycerides/blood
MH  - Uric Acid/blood
MH  - Xanthine Oxidase/*blood
EDAT- 2018/02/14 06:00
MHDA- 2018/07/20 06:00
CRDT- 2018/02/14 06:00
PHST- 2017/07/17 00:00 [received]
PHST- 2018/01/11 00:00 [accepted]
PHST- 2018/02/14 06:00 [pubmed]
PHST- 2018/07/20 06:00 [medline]
PHST- 2018/02/14 06:00 [entrez]
AID - dc17-1434 [pii]
AID - 10.2337/dc17-1434 [doi]
PST - ppublish
SO  - Diabetes Care. 2018 Apr;41(4):884-890. doi: 10.2337/dc17-1434. Epub 2018 Feb 2.