PMID- 29439622
OWN - NLM
STAT- MEDLINE
DCOM- 20181106
LR  - 20181106
IS  - 1933-7205 (Electronic)
IS  - 1933-7191 (Linking)
VI  - 25
IP  - 7
DP  - 2018 Jul
TI  - Caloric Restriction Dramatically Stalls Lesion Growth in Mice With Induced 
      Endometriosis.
PG  - 1024-1036
LID - 10.1177/1933719118756755 [doi]
AB  - Caloric restriction (CR) has been demonstrated to have many health-beneficial 
      effects in many species, but whether CR can impede the development of 
      endometriosis is unknown. To test the hypothesis that CR can impede the growth of 
      endometriotic lesions and fibrogenesis, we conducted 2 experiments. In experiment 
      1, 20 female Balb/C mice were randomly assigned to either ad libitum (AL) group 
      that was fed AL or to CR group that was fed 30% less calories than that of AL 
      mice. Two weeks after the implementation of the dietary intervention, 
      endometriosis was induced by intraperitoneal injection of endometrial fragments. 
      Two weeks after the induction, all mice were sacrificed and their lesion samples 
      were evaluated. In experiment 2, another 20 mice were used and CR was implemented 
      2 weeks after induction of endometriosis and lasted for 4 weeks. Caloric 
      restriction instituted before the induction of endometriosis reduced the lesion 
      weight by 88.5%, whereas CR implemented well after lesions were established 
      reduced the lesion weight by 93.0%. In both cases, CR significantly increased 
      staining levels of markers of autophagy but reduced proliferation, angiogenesis, 
      steroidogenesis, and fibrosis in lesions as compared with the AL group. 
      Consequently, CR, instituted either before or after the induction of 
      endometriosis, dramatically curbs the growth of endometriotic lesions and 
      fibrogenesis through multiple mechanisms. Caloric restriction and CR mimetics, a 
      family of compounds mimicking the beneficial effect of CR, even when instituted 
      well after lesions are established, may stall the development of endometriosis. 
      Given the scarcity in research on how lifestyle can impact on the development of 
      endometriosis, our study should hopefully stimulate more research in this area.
FAU - Yin, Bo
AU  - Yin B
AD  - 1 Shanghai Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China.
FAU - Liu, Xishi
AU  - Liu X
AD  - 1 Shanghai Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China.
AD  - 2 Shanghai Key Laboratory of Female Reproductive Endocrine-Related Diseases, 
      Shanghai, China.
FAU - Guo, Sun-Wei
AU  - Guo SW
AD  - 1 Shanghai Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China.
AD  - 2 Shanghai Key Laboratory of Female Reproductive Endocrine-Related Diseases, 
      Shanghai, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180213
PL  - United States
TA  - Reprod Sci
JT  - Reproductive sciences (Thousand Oaks, Calif.)
JID - 101291249
SB  - IM
MH  - Animals
MH  - *Caloric Restriction
MH  - Cell Proliferation
MH  - Endometriosis/metabolism/*pathology/*physiopathology
MH  - Female
MH  - Fibrosis
MH  - Mice, Inbred BALB C
MH  - Neovascularization, Pathologic
MH  - Signal Transduction
OTO - NOTNLM
OT  - autophagy
OT  - caloric restriction
OT  - endometriosis
OT  - fibrogenesis
OT  - mouse
EDAT- 2018/02/15 06:00
MHDA- 2018/11/07 06:00
CRDT- 2018/02/15 06:00
PHST- 2018/02/15 06:00 [pubmed]
PHST- 2018/11/07 06:00 [medline]
PHST- 2018/02/15 06:00 [entrez]
AID - 10.1177/1933719118756755 [doi]
PST - ppublish
SO  - Reprod Sci. 2018 Jul;25(7):1024-1036. doi: 10.1177/1933719118756755. Epub 2018 
      Feb 13.