PMID- 29439646
OWN - NLM
STAT- MEDLINE
DCOM- 20180925
LR  - 20180925
IS  - 1477-0962 (Electronic)
IS  - 0961-2033 (Linking)
VI  - 27
IP  - 6
DP  - 2018 May
TI  - The influence of functional polymorphic positions of HLA-DRbeta1 molecules on risk 
      for South Indian systemic lupus erythematosus patients.
PG  - 991-1000
LID - 10.1177/0961203318759200 [doi]
AB  - The aim of this case-control study was to investigate the association of human 
      leukocyte antigen (HLA) Class II alleles with the susceptibility and phenotypic 
      heterogeneity in systemic lupus erythematosus (SLE) in South Indian patients. A 
      total of 439 individuals (212 SLE cases and 227 age- and ethnicity-matched 
      controls) were included in the study. The genotyping of HLA-DRbeta1 and - DQbeta1 was 
      conducted by the PCR-SSP method. HLA-DRbeta1*07 was significantly associated with 
      SLE (OR: 2.02; 95% CI: 1.34-3.04, p = 1.50 x 10(-4), p(c) = 1.95 x 10(-3)), 
      whereas the DRbeta1*14 allele was negatively associated with SLE (OR: 0.49; 95% CI: 
      0.31-0.76, p = 1.70 x 10(-2), p(c) = 0.221). In addition, the HLA-DRbeta1*07/15 
      genotype tended to be positively associated with SLE (OR: 3.23, 95% CI: 
      1.57-6.63, p = 0.0009). Amino acid residues residing in the peptide-binding 
      pocket of HLA-DRbeta1 play a significant role in peptide recruitment and antigen 
      presentation. Our results demonstrated that amino acid glycine 11 (OR: 2.11, 95% 
      CI: 1.42-3.12, p(c) = 0.00093), tyrosine 13 (OR: 2.11, 95% CI: 1.42-3.12, 
      p(c) = 0.00062) and glutamine 74 (OR: 2.11, 95% CI: 1.42-3.12, p(c) = 0.00077) 
      showed a significant positive association with SLE. Certain haplotype 
      combinations, DRB1*07-DQbeta1*03 (OR: 2.21; 95% CI:1.29-3.79, p(c) = 0.06, p =  
      0.00036) and DRbeta1*07-DQbeta1*05 (OR: 2.51, 95% CI: 1.34-4.71, p(c) = 0.07, 
      p = 0.00039), had positive associations whereas DRbeta1*14-DQbeta1*03 (OR: 0.14, 95% 
      CI: 0.061-0.36, p(c) = 2.34 x 10(-5), p = 1.30 x 10(-6)) were found to have a 
      significant negative association with SLE. So far, the present study is the first 
      attempt to investigate the association of HLA-DRbeta1 and - DQbeta1 allele, genotype 
      and haplotype combinations with the risk of SLE in South Indian patients. In 
      conclusion, the HLA-DRbeta1*07 allele is associated with risk of SLE whereas a 
      protective association of HLA-DRbeta1*14 alleles with SLE was observed.
FAU - Katkam, S K
AU  - Katkam SK
AD  - 1 Department of Clinical Pharmacology and Therapeutics, 28605 Nizam's Institute 
      of Medical Sciences (NIMS) , Telangana, Hyderabad, India.
FAU - Rajasekhar, L
AU  - Rajasekhar L
AD  - 2 Department of Clinical Immunology and Rheumatology, 28605 Nizam's Institute of 
      Medical Sciences (NIMS) , Telangana, Hyderabad, India.
FAU - Kutala, V K
AU  - Kutala VK
AD  - 1 Department of Clinical Pharmacology and Therapeutics, 28605 Nizam's Institute 
      of Medical Sciences (NIMS) , Telangana, Hyderabad, India.
LA  - eng
PT  - Journal Article
DEP - 20180213
PL  - England
TA  - Lupus
JT  - Lupus
JID - 9204265
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*07 antigen)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Female
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - HLA-DQ beta-Chains/genetics/immunology
MH  - HLA-DRB1 Chains/*genetics/immunology
MH  - Haplotypes
MH  - Humans
MH  - India/epidemiology
MH  - Lupus Erythematosus, Systemic/diagnosis/ethnology/*genetics/immunology
MH  - Male
MH  - Odds Ratio
MH  - Phenotype
MH  - *Polymorphism, Single Nucleotide
MH  - Protective Factors
MH  - Risk Factors
MH  - Young Adult
OTO - NOTNLM
OT  - Systemic lupus erythematosus
OT  - autoantibody
OT  - autoimmune disease
OT  - human leukocyte antigen
OT  - major histocompatibility complex
OT  - polymorphism
EDAT- 2018/02/15 06:00
MHDA- 2018/09/27 06:00
CRDT- 2018/02/15 06:00
PHST- 2018/02/15 06:00 [pubmed]
PHST- 2018/09/27 06:00 [medline]
PHST- 2018/02/15 06:00 [entrez]
AID - 10.1177/0961203318759200 [doi]
PST - ppublish
SO  - Lupus. 2018 May;27(6):991-1000. doi: 10.1177/0961203318759200. Epub 2018 Feb 13.