PMID- 29439738 OWN - NLM STAT- MEDLINE DCOM- 20190605 LR - 20231112 IS - 1475-2891 (Electronic) IS - 1475-2891 (Linking) VI - 17 IP - 1 DP - 2018 Feb 13 TI - Dietary inflammatory index: a potent association with cardiovascular risk factors among patients candidate for coronary artery bypass grafting (CABG) surgery. PG - 20 LID - 10.1186/s12937-018-0325-2 [doi] LID - 20 AB - BACKGROUND: Recently, the clinical importance of dietary inflammatory index (DII) in predicting the inflammatory potential of diet and its role in pathogenesis of several chronic disease including some types of cancers, osteoporosis, cardiovascular disease and renal disease has been proposed. However, its association with the disease severity and progression and cardio-metabolic risk factors among patients candidate for coronary artery bypass graft surgery (CABG) has not been evaluated yet. In the current study, the association of DII with cardiovascular risk factors among patients candidate for CABG has been investigated. METHODS: In the current cross-sectional study, 454 patients aged 35-80 years as candidates of CABG and hospitalized in Tehran Heart Center were enrolled. Anthropometric and demographic characteristics were obtained from all of the participants. Dietary intakes were evaluated with a semi-quantitative food-frequency questionnaire (FFQ) and DII was calculated. Biochemical parameters including hemoglobin (Hb) A(1)C, serum lipids, albumin, creatinine and high-sensitive C-reactive protein (hs-CRP), lipoprotein (a), creatinine, blood urea nitrogen (BUN), albumin and hematocrit (HCT) were also assessed by commercial laboratory methods. Left ventricular ejection- fraction, number of diseased vessels, New York Heart Association (NYHA) functional class and the European system for cardiac operative risk evaluation (EuroSCORE) were estimated for clinical assessment. One way analysis of variance and chi square tests were used for comparison of demographic parameters between groups. Beta estimates and 95% confidence intervals (CI) for the association between DII and clinical parameters were estimated using linear regression adjusted for the confounders. RESULTS: According to our findings, high DII scores were associated with higher age, lower body mass index (BMI), higher prevalence of diabetes and myocardial infarction (MI) and lower educational attainment (P < 0.05). Male patients in 4th and 3rd quartile of DII had significantly higher total cholesterol (TC), triglyceride (TG), albumin, creatinine, BUN and hs-CRP concentrations and lower high density lipoprotein cholesterol (HDL) concentrations compared with male patients in lower quartiles (P < 0.05). While in female patients, only lipoprotein (a) concentrations and hematocrit (HCT) percentage in the 4th and 2nd quartile were significantly higher than lower quartiles. EuroSCORE was also significantly higher in top quartiles of DII (P = 0.006). CONCLUSION: As shown in our results, DII was in a positive association with several cardiovascular risk factors. The higher inflammatory potential of diet denoted higher values of serum lipids, CRP and kidney function tests and higher EuroSCORE as a predictor of post-operative mortality. Therefore, DII can be demonstrated as a target of nutritional interventions for ameliorating the CVD risk factors among patients candidate for CABG especially in male patients. FAU - Farhangi, Mahdieh Abbasalizad AU - Farhangi MA AD - Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. FAU - Najafi, Mahdi AU - Najafi M AD - Department of Research, Tehran Heart Center, Tehran University of Medical Sciences, North Karegar Street, Tehran, 1411713138, Iran. najafik@sina.tums.ac.ir. AD - Cardiac Outcome Research and Education (CORE), Universal Scientific Education and Research Network (USERN), Tehran, Iran. najafik@sina.tums.ac.ir. LA - eng PT - Journal Article DEP - 20180213 PL - England TA - Nutr J JT - Nutrition journal JID - 101152213 RN - 0 (Biomarkers) RN - 0 (Glycated Hemoglobin A) RN - 0 (Triglycerides) RN - 9007-41-4 (C-Reactive Protein) RN - AYI8EX34EU (Creatinine) SB - IM MH - Adult MH - Age Factors MH - Aged MH - Aged, 80 and over MH - Biomarkers/blood MH - Body Mass Index MH - C-Reactive Protein/metabolism MH - Cardiovascular Diseases/*blood/*diagnosis/surgery MH - *Coronary Artery Bypass MH - Creatinine/blood MH - Cross-Sectional Studies MH - Diet/*methods MH - Female MH - Glycated Hemoglobin/metabolism MH - Humans MH - Inflammation/*blood/*diagnosis MH - Iran MH - Male MH - Middle Aged MH - Risk Factors MH - Severity of Illness Index MH - Triglycerides/blood PMC - PMC5812038 OTO - NOTNLM OT - CABG OT - Cardiovascular disease OT - Dietary inflammatory index OT - Hs-CRP COIS- COMPETING INTEREST: The authors declare that there is no conflict of interest. ETHICS APPROVAL AND CONSENT TO PARTICIPATE: The study protocol has been approved by the ethics committee of the Tehran University of Medical Sciences. CONSENT FOR PUBLICATION: Not applicable. PUBLISHER'S NOTE: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. EDAT- 2018/02/15 06:00 MHDA- 2019/06/06 06:00 PMCR- 2018/02/13 CRDT- 2018/02/15 06:00 PHST- 2017/09/15 00:00 [received] PHST- 2018/01/15 00:00 [accepted] PHST- 2018/02/15 06:00 [entrez] PHST- 2018/02/15 06:00 [pubmed] PHST- 2019/06/06 06:00 [medline] PHST- 2018/02/13 00:00 [pmc-release] AID - 10.1186/s12937-018-0325-2 [pii] AID - 325 [pii] AID - 10.1186/s12937-018-0325-2 [doi] PST - epublish SO - Nutr J. 2018 Feb 13;17(1):20. doi: 10.1186/s12937-018-0325-2.