PMID- 29440622
OWN - NLM
STAT- MEDLINE
DCOM- 20190320
LR  - 20231213
IS  - 1470-8736 (Electronic)
IS  - 0143-5221 (Print)
IS  - 0143-5221 (Linking)
VI  - 132
IP  - 4
DP  - 2018 Feb 28
TI  - Short-term early exposure to thirdhand cigarette smoke increases lung cancer 
      incidence in mice.
PG  - 475-488
LID - 10.1042/CS20171521 [doi]
AB  - Exposure to thirdhand smoke (THS) is a recently described health concern that 
      arises in many indoor environments. However, the carcinogenic potential of THS, a 
      critical consideration in risk assessment, remains untested. Here we investigated 
      the effects of short-term early exposure to THS on lung carcinogenesis in A/J 
      mice. Forty weeks after THS exposure from 4 to 7 weeks of age, the mice had 
      increased incidence of lung adenocarcinoma, tumor size and, multiplicity, 
      compared with controls. In vitro studies using cultured human lung cancer cells 
      showed that THS exposure induced DNA double-strand breaks and increased cell 
      proliferation and colony formation. RNA sequencing analysis revealed that THS 
      exposure induced endoplasmic reticulum stress and activated p53 signaling. 
      Activation of the p53 pathway was confirmed by an increase in its targets p21 and 
      BAX. These data indicate that early exposure to THS is associated with increased 
      lung cancer risk.
CI  - (c) 2018 The Author(s).
FAU - Hang, Bo
AU  - Hang B
AD  - Biological Systems and Engineering Division, Lawrence Berkeley National 
      Laboratory, Berkeley, CA 94720, U.S.A.
FAU - Wang, Yunshan
AU  - Wang Y
AD  - Biological Systems and Engineering Division, Lawrence Berkeley National 
      Laboratory, Berkeley, CA 94720, U.S.A.
AD  - International Biotechnology R&D Center, Shandong University School of Ocean, 
      Weihai, Shandong 264209, China.
FAU - Huang, Yurong
AU  - Huang Y
AD  - Biological Systems and Engineering Division, Lawrence Berkeley National 
      Laboratory, Berkeley, CA 94720, U.S.A.
FAU - Wang, Pin
AU  - Wang P
AD  - Biological Systems and Engineering Division, Lawrence Berkeley National 
      Laboratory, Berkeley, CA 94720, U.S.A.
AD  - Department of Gastroenterology, Nanjing Drum Tower Hospital, Nanjing University 
      Medical School, Nanjing, Jiangsu 210008, China.
FAU - Langley, Sasha A
AU  - Langley SA
AD  - Biological Systems and Engineering Division, Lawrence Berkeley National 
      Laboratory, Berkeley, CA 94720, U.S.A.
FAU - Bi, Lei
AU  - Bi L
AD  - Biological Systems and Engineering Division, Lawrence Berkeley National 
      Laboratory, Berkeley, CA 94720, U.S.A.
FAU - Sarker, Altaf H
AU  - Sarker AH
AD  - Biological Systems and Engineering Division, Lawrence Berkeley National 
      Laboratory, Berkeley, CA 94720, U.S.A.
FAU - Schick, Suzaynn F
AU  - Schick SF
AD  - Department of Medicine, Division of Occupational and Environmental Medicine, 
      University of California, San Francisco, Box 0843, San Francisco, CA 94143, 
      U.S.A.
FAU - Havel, Christopher
AU  - Havel C
AD  - Division of Clinical Pharmacology and Experimental Therapeutics, Department of 
      Medicine University of California, San Francisco, Box 0843, San Francisco, CA 
      94143, U.S.A.
FAU - Jacob, Peyton 3rd
AU  - Jacob P 3rd
AD  - Division of Clinical Pharmacology and Experimental Therapeutics, Department of 
      Medicine University of California, San Francisco, Box 0843, San Francisco, CA 
      94143, U.S.A.
FAU - Benowitz, Neal
AU  - Benowitz N
AD  - Division of Clinical Pharmacology and Experimental Therapeutics, Medical 
      Services, Department of Medicine, and Bioengineering & Therapeutic Sciences, 
      University of California, San Francisco, Box 0843, San Francisco, CA 94143, 
      U.S.A.
FAU - Destaillats, Hugo
AU  - Destaillats H
AD  - Indoor Environment Group, Energy Technologies Area, Lawrence Berkeley National 
      Laboratory, Berkeley, CA 94720, U.S.A.
FAU - Tang, Xiaochen
AU  - Tang X
AD  - Indoor Environment Group, Energy Technologies Area, Lawrence Berkeley National 
      Laboratory, Berkeley, CA 94720, U.S.A.
FAU - Xia, Yankai
AU  - Xia Y
AD  - State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing 
      Medical University, Nanjing 211166, China.
FAU - Jen, Kuang-Yu
AU  - Jen KY
AD  - Department of Pathology and Laboratory Medicine, University of California Davis 
      Medical Center, Sacramento, CA 95817, U.S.A.
FAU - Gundel, Lara A
AU  - Gundel LA
AD  - Indoor Environment Group, Energy Technologies Area, Lawrence Berkeley National 
      Laboratory, Berkeley, CA 94720, U.S.A.
FAU - Mao, Jian-Hua
AU  - Mao JH
AD  - Biological Systems and Engineering Division, Lawrence Berkeley National 
      Laboratory, Berkeley, CA 94720, U.S.A. JHMao@lbl.gov AMSnijders@lbl.gov.
AD  - Berkeley Biomedical Data Science Center, Lawrence Berkeley National Laboratory, 
      Berkeley, CA 94720, U.S.A.
FAU - Snijders, Antoine M
AU  - Snijders AM
AD  - Biological Systems and Engineering Division, Lawrence Berkeley National 
      Laboratory, Berkeley, CA 94720, U.S.A. JHMao@lbl.gov AMSnijders@lbl.gov.
AD  - Berkeley Biomedical Data Science Center, Lawrence Berkeley National Laboratory, 
      Berkeley, CA 94720, U.S.A.
LA  - eng
GR  - P30 DA012393/DA/NIDA NIH HHS/United States
GR  - S10 RR026437/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20180228
PL  - England
TA  - Clin Sci (Lond)
JT  - Clinical science (London, England : 1979)
JID - 7905731
RN  - 0 (Tobacco Smoke Pollution)
SB  - IM
MH  - Animals
MH  - Cell Proliferation/physiology
MH  - Disease Models, Animal
MH  - Incidence
MH  - Lung Neoplasms/*chemically induced
MH  - Mice
MH  - Smoking/*adverse effects
MH  - *Time Factors
MH  - Nicotiana/adverse effects
MH  - Tobacco Smoke Pollution/*adverse effects
PMC - PMC6365648
OTO - NOTNLM
OT  - DNA double strand breaks
OT  - cigarette smoke
OT  - lung carcinogenesis
OT  - thirdhand smoke
COIS- Dr. Benowitz has been an expert witness in litigation against tobacco companies. 
      The other authors declare no competing financial interests.
EDAT- 2018/02/15 06:00
MHDA- 2019/03/21 06:00
PMCR- 2018/02/28
CRDT- 2018/02/15 06:00
PHST- 2017/11/13 00:00 [received]
PHST- 2018/02/02 00:00 [revised]
PHST- 2018/02/09 00:00 [accepted]
PHST- 2018/02/15 06:00 [pubmed]
PHST- 2019/03/21 06:00 [medline]
PHST- 2018/02/15 06:00 [entrez]
PHST- 2018/02/28 00:00 [pmc-release]
AID - CS20171521 [pii]
AID - 10.1042/CS20171521 [doi]
PST - epublish
SO  - Clin Sci (Lond). 2018 Feb 28;132(4):475-488. doi: 10.1042/CS20171521. Print 2018 
      Feb 28.