PMID- 29440903
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220311
IS  - 1176-6328 (Print)
IS  - 1178-2021 (Electronic)
IS  - 1176-6328 (Linking)
VI  - 14
DP  - 2018
TI  - Association of the matrix metalloproteinase-3 polymorphisms rs679620 and 
      rs3025058 with ischemic stroke risk: a meta-analysis.
PG  - 419-427
LID - 10.2147/NDT.S152256 [doi]
AB  - PURPOSE: The relationship of the matrix metalloproteinase-3 (MMP-3) polymorphisms 
      rs679620 and rs3025058 with ischemic stroke has received much attention. The aim 
      of the present study was to perform a meta-analysis of published case-control 
      studies to evaluate the cumulative evidence. METHODS: We performed a search of 
      ISI Web of Science, Embase, PubMed, and China National Knowledge Infrastructure 
      databases. Pooled odds ratios (ORs) were appropriately derived from fixed-effects 
      or random-effects models. RESULTS: We identified seven eligible studies including 
      5,204 subjects. The pooled analysis showed that the MMP-3 rs679620 A allele 
      carriers had increased risk of ischemic stroke compared with homozygotes for the 
      G allele in Asians (AA + GA vs GG: OR =1.42, 95% CI: 1.05-1.91, P=0.022). 
      Concerning the rs3025058 polymorphism, the results did not suggest an association 
      between rs3025058 genotypes and ischemic stroke risk (5A5A + 6A5A vs 6A6A: OR 
      =1.04, 95% CI: 0.73-1.47, P=0.844; 5A5A vs 6A5A + 6A6A: OR =1.14, 95% CI: 
      0.74-1.77, P=0.556; and 5A5A vs 6A6A: OR =1.11, 95% CI: 0.68-1.80, P=0.677). In 
      subgroup analysis by ethnicity, no statistically significant associations were 
      demonstrated for rs3025058 in Asians and Caucasians, respectively. There was no 
      evidence for publication bias. CONCLUSION: Our findings indicate that the 
      rs679620 A allele carriers have increased risk of ischemic stroke in Asians, but 
      there is no association between rs3025058 and ischemic stroke risk.
FAU - Zhang, Qi-Wei
AU  - Zhang QW
AD  - Department of Neurosurgery, The Affiliated Hospital of Jilin Medical University, 
      Jilin, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20180131
PL  - New Zealand
TA  - Neuropsychiatr Dis Treat
JT  - Neuropsychiatric disease and treatment
JID - 101240304
PMC - PMC5798548
OTO - NOTNLM
OT  - MMP-3
OT  - ischemic stroke
OT  - meta-analysis
OT  - polymorphism
COIS- Disclosure The author reports no conflicts of interest in this work.
EDAT- 2018/02/15 06:00
MHDA- 2018/02/15 06:01
PMCR- 2018/01/31
CRDT- 2018/02/15 06:00
PHST- 2018/02/15 06:00 [entrez]
PHST- 2018/02/15 06:00 [pubmed]
PHST- 2018/02/15 06:01 [medline]
PHST- 2018/01/31 00:00 [pmc-release]
AID - ndt-14-419 [pii]
AID - 10.2147/NDT.S152256 [doi]
PST - epublish
SO  - Neuropsychiatr Dis Treat. 2018 Jan 31;14:419-427. doi: 10.2147/NDT.S152256. 
      eCollection 2018.