PMID- 29442475
OWN - NLM
STAT- MEDLINE
DCOM- 20190321
LR  - 20190321
IS  - 1827-1634 (Electronic)
IS  - 0391-1977 (Linking)
VI  - 43
IP  - 4
DP  - 2018 Dec
TI  - Association of heterogeneity of the thyroid gland with matrix metalloproteinase-3 
      in rheumatoid arthritis patients with Hashimoto's thyroiditis.
PG  - 398-405
LID - 10.23736/S0391-1977.18.02725-6 [doi]
AB  - BACKGROUND: Hashimoto's thyroiditis (HT) is highly prevalent in patients with 
      rheumatoid arthritis (RA). The aim is to determine their relation, focusing on 
      matrix metalloproteinase-3 (MMP-3), a marker predicting joint destruction and RA 
      activity. METHODS: Fifty-three consecutive RA patients were prospectively 
      separated into two groups based on the presence or absence of HT; those with and 
      without TPO-Ab or Tg-Ab (34.0% and 66.0%, respectively). To estimate the extent 
      of inflammation and destruction of the thyroid gland, Heterogeneity Index (HI) 
      was determined ultrasonographically. RESULTS: While the male/female ratio, TSH 
      and HI were significantly higher in those with HT than in those without (5/13 vs. 
      7/28, P=0.047, mean+/-SE; 7.25+/-0.69 vs.2.52+/-0.30 mIU/L, P<0.001; 3.8+/-0.2 
      vs.3.2+/-0.2%, P=0.042, respectively), no differences existed in MMP-3. In those 
      with HT, MMP-3 correlated negatively with FT3 (rho=-0.545, P=0.048) and 
      positively with TPO-Ab and HI (rho=0.735, P=0.02; rho=0.769, P=0.01, 
      respectively). Among them, HI was a significant factor associated positively with 
      MMP-3 (r=0.883, F=31.91). CONCLUSIONS: The present study demonstrated significant 
      increases of HI and an association between HI and MMP-3 in RA patients with HT. 
      These findings suggest that the inflammation and destruction of the thyroid gland 
      might be closely related to the current activity and terminal joint destruction 
      of RA.
FAU - Nagasaki, Toshiki
AU  - Nagasaki T
AD  - Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City 
      University, Graduate School of Medicine, Osaka, Japan - toshi-n@jg7.so-net.ne.jp.
FAU - Nagata, Yuki
AU  - Nagata Y
AD  - Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City 
      University, Graduate School of Medicine, Osaka, Japan.
FAU - Wakita, Yosuke
AU  - Wakita Y
AD  - Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City 
      University, Graduate School of Medicine, Osaka, Japan.
FAU - Yamada, Shinsuke
AU  - Yamada S
AD  - Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City 
      University, Graduate School of Medicine, Osaka, Japan.
FAU - Goto, Hitoshi
AU  - Goto H
AD  - Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City 
      University, Graduate School of Medicine, Osaka, Japan.
FAU - Imanishi, Yasuo
AU  - Imanishi Y
AD  - Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City 
      University, Graduate School of Medicine, Osaka, Japan.
FAU - Onoda, Naoyoshi
AU  - Onoda N
AD  - Department of Surgical Oncology, Osaka City University, Graduate School of 
      Medicine, Osaka, Japan.
FAU - Emoto, Masanori
AU  - Emoto M
AD  - Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City 
      University, Graduate School of Medicine, Osaka, Japan.
FAU - Inaba, Masaaki
AU  - Inaba M
AD  - Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City 
      University, Graduate School of Medicine, Osaka, Japan.
LA  - eng
PT  - Journal Article
DEP - 20180213
PL  - Italy
TA  - Minerva Endocrinol
JT  - Minerva endocrinologica
JID - 8406505
RN  - EC 3.4.24.17 (MMP3 protein, human)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Arthritis, Rheumatoid/*genetics/*pathology
MH  - Female
MH  - Hashimoto Disease/*genetics/*pathology
MH  - Humans
MH  - Joints/pathology
MH  - Male
MH  - Matrix Metalloproteinase 3/*genetics
MH  - Middle Aged
MH  - Prospective Studies
MH  - Thyroid Gland/*pathology
EDAT- 2018/02/15 06:00
MHDA- 2019/03/22 06:00
CRDT- 2018/02/15 06:00
PHST- 2018/02/15 06:00 [pubmed]
PHST- 2019/03/22 06:00 [medline]
PHST- 2018/02/15 06:00 [entrez]
AID - S0391-1977.18.02725-6 [pii]
AID - 10.23736/S0391-1977.18.02725-6 [doi]
PST - ppublish
SO  - Minerva Endocrinol. 2018 Dec;43(4):398-405. doi: 10.23736/S0391-1977.18.02725-6. 
      Epub 2018 Feb 13.