PMID- 29442627
OWN - NLM
STAT- MEDLINE
DCOM- 20180806
LR  - 20211204
IS  - 1533-4880 (Print)
IS  - 1533-4880 (Linking)
VI  - 18
IP  - 7
DP  - 2018 Jul 1
TI  - Studies on Mechanical, Biocompatibility and Antibacterial Activity of Plasma 
      Sprayed Nano/Micron Ceramic Bilayered Coatings on Ti-6Al-4V Alloy for Biomedical 
      Application.
PG  - 4515-4523
LID - 10.1166/jnn.2018.15332 [doi]
AB  - Ceramic oxides such as alumina and zirconia are used to fabricate dental and 
      orthopedic implants. However, their usage is limited as they fail due to low 
      fracture toughness. To overcome this issue, ceramic coatings on metallic implants 
      is attempted to have a combined effect of ceramics and metallic materials. This 
      paper reports on the microstructure, phase analysis, mechanical properties, 
      osseointegration and antibacterial activity of three different wear-resistant 
      coatings developed on Ti-6Al-4V alloy which is used widely as orthopedic and 
      dental implants. The powders of following compositions, i. Nanostructured Al2O3 + 
      13 wt% TiO2/mu-TiO2 BL coating (S1), ii. mu-Al2O3 + 13 wt% nanostructured 
      TiO2/mu-TiO2 BL coating (S2), iii. Nanostructured Al2O3 + 13 wt% TiO2/mu-YSZ BL 
      coating (S3), were sprayed using atmospheric plasma spray process onto Ti-6Al-4V 
      alloy. The coatings were characterized using X-ray diffraction (XRD), Scanning 
      electron microscope (SEM), Profilometer and gonieometer to determine their 
      phases, microstructure, surface roughness and contact angle. In addition, micro 
      indentation hardness and scratch resistance were also evaluated. Amongst the 
      three coatings, S2 exhibited higher hardness value with higher scratch 
      resistance. The antibacterial activity was studied using colony formation on all 
      three coatings. The antibacterial efficiency of S1 as well as S3 coatings was 
      higher as seen from less number of bacterial colonies on the surface. The results 
      of in-vitro studies on the biocompatibility of nano/micron alumina and zirconia 
      ceramic coatings which were analyzed with hMSC's, reveals that S1 is cytotoxic 
      with less number of cell attachment when compared to S2 and S3.
FAU - Veerachamy, Suganthan
AU  - Veerachamy S
AD  - Surface Engineering Lab, Centre for Biomaterials, Cellular and Molecular 
      Theranostics, VIT University, Vellore 632014, India.
FAU - Hameed, Pearlin
AU  - Hameed P
AD  - Cellular and Molecular Therapeutics Lab, Centre for Biomaterials, Cellular and 
      Molecular Theranostics, VIT University, Vellore 632014, India.
FAU - Sen, Dwaipayan
AU  - Sen D
AD  - Cellular and Molecular Therapeutics Lab, Centre for Biomaterials, Cellular and 
      Molecular Theranostics, VIT University, Vellore 632014, India.
FAU - Dash, Sitaram
AU  - Dash S
AD  - Surface Engineering Lab, Centre for Biomaterials, Cellular and Molecular 
      Theranostics, VIT University, Vellore 632014, India.
FAU - Manivasagam, Geetha
AU  - Manivasagam G
AD  - Surface Engineering Lab, Centre for Biomaterials, Cellular and Molecular 
      Theranostics, VIT University, Vellore 632014, India.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Nanosci Nanotechnol
JT  - Journal of nanoscience and nanotechnology
JID - 101088195
RN  - 0 (Alloys)
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Coated Materials, Biocompatible)
RN  - 12743-70-3 (titanium alloy (TiAl6V4))
RN  - D1JT611TNE (Titanium)
SB  - IM
MH  - Alloys
MH  - Anti-Bacterial Agents/*chemistry/pharmacology
MH  - *Ceramics
MH  - *Coated Materials, Biocompatible
MH  - Materials Testing
MH  - Microscopy, Electron, Scanning
MH  - *Nanostructures
MH  - Surface Properties
MH  - *Titanium
EDAT- 2018/02/15 06:00
MHDA- 2018/08/07 06:00
CRDT- 2018/02/15 06:00
PHST- 2018/02/15 06:00 [entrez]
PHST- 2018/02/15 06:00 [pubmed]
PHST- 2018/08/07 06:00 [medline]
AID - 10.1166/jnn.2018.15332 [doi]
PST - ppublish
SO  - J Nanosci Nanotechnol. 2018 Jul 1;18(7):4515-4523. doi: 10.1166/jnn.2018.15332.