PMID- 29442811
OWN - NLM
STAT- MEDLINE
DCOM- 20180730
LR  - 20201209
IS  - 1533-4880 (Print)
IS  - 1533-4880 (Linking)
VI  - 18
IP  - 5
DP  - 2018 May 1
TI  - Immobilization of N-Halamine Based Polycation on Nanodiamonds for High Dispersity 
      and Enhanced Biocidal Activity.
PG  - 3126-3133
LID - 10.1166/jnn.2018.14544 [doi]
AB  - Novel bactericidal materials, polycation-based N-halamine functionalized 
      nanodiamonds (PCN-NDs), were fabricated by coating of nanodiamonds (NDs) with 
      quaternarized N-halamine polymers via a facile approach. Chemical modification of 
      the particles was confirmed by FTIR, XPS and TGA. The particle diameters and 
      dispersity of the functionalized NDs were investigated by TEM and DLS 
      measurements. It was found that ND tight core aggregates could be broken into 
      tiny nanoparticles with 40-50 nm through functionalization procedure, which 
      resulted in stable colloidal dispersion solution over one month. The 
      antibacterial tests showed that the PCN-NDs exhibited enhanced antibacterial 
      activity against Gram-negative Escherichia coli (E. coli) and Gram-positive 
      Staphylococcus aureus (S. aureus) compared with their bulk counterparts. The 
      minimum inhibitory concentration values of the as-prepared PCN-NDs are 62.5 mug/mL 
      for both E. coli and S. aureus, even PCN-NDs eliminated nearly 100% of E. coil 
      and S. aureus (107-108 CFU/mg nanoparticles) within 15 min. Furthermore, the 
      as-prepared antimicrobial PCN-NDs exhibited good storage stability and 
      regenerability.
FAU - Peng, Xuefeng
AU  - Peng X
AD  - College of Chemical Engineering, Nanjing University of Science and Technology, 
      Nanjing 210094, China.
FAU - Cao, Weiwei
AU  - Cao W
AD  - College of Chemical Engineering, Nanjing University of Science and Technology, 
      Nanjing 210094, China.
FAU - Jin, Feng
AU  - Jin F
AD  - College of Chemical Engineering, Nanjing University of Science and Technology, 
      Nanjing 210094, China.
FAU - Wang, Xi
AU  - Wang X
AD  - College of Chemical Engineering, Nanjing University of Science and Technology, 
      Nanjing 210094, China.
FAU - Li, Qiang
AU  - Li Q
AD  - College of Chemical Engineering, Nanjing University of Science and Technology, 
      Nanjing 210094, China.
FAU - Chen, Huinan
AU  - Chen H
AD  - College of Chemical Engineering, Nanjing University of Science and Technology, 
      Nanjing 210094, China.
FAU - Xing, Xiaodong
AU  - Xing X
AD  - College of Chemical Engineering, Nanjing University of Science and Technology, 
      Nanjing 210094, China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Nanosci Nanotechnol
JT  - Journal of nanoscience and nanotechnology
JID - 101088195
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Nanodiamonds)
RN  - 0 (Polyamines)
RN  - 0 (Polyelectrolytes)
RN  - 0 (polycations)
SB  - IM
MH  - Anti-Bacterial Agents/*pharmacology
MH  - Escherichia coli/drug effects
MH  - Microbial Sensitivity Tests
MH  - *Nanodiamonds
MH  - Polyamines/*pharmacology
MH  - Polyelectrolytes
MH  - Staphylococcus aureus/drug effects
EDAT- 2018/02/15 06:00
MHDA- 2018/07/31 06:00
CRDT- 2018/02/15 06:00
PHST- 2018/02/15 06:00 [entrez]
PHST- 2018/02/15 06:00 [pubmed]
PHST- 2018/07/31 06:00 [medline]
AID - 10.1166/jnn.2018.14544 [doi]
PST - ppublish
SO  - J Nanosci Nanotechnol. 2018 May 1;18(5):3126-3133. doi: 10.1166/jnn.2018.14544.