PMID- 29443743
OWN - NLM
STAT- MEDLINE
DCOM- 20180222
LR  - 20221005
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 97
IP  - 7
DP  - 2018 Feb
TI  - Circulating miR-146a/b correlates with inflammatory cytokines in COPD and could 
      predict the risk of acute exacerbation COPD.
PG  - e9820
LID - 10.1097/MD.0000000000009820 [doi]
LID - e9820
AB  - The aim of this study was to investigate the predicting value of miR-146a/b for 
      acute exacerbation chronic obstructive pulmonary disease (AECOPD) and COPD, and 
      to explore their associations with inflammatory cytokines in AECOPD and stable 
      COPD patients.One hundred six AECOPD, 122 stable COPD patients, and 110 health 
      volunteers with age and sex matched to total COPD patients (AECOPD and stable 
      COPD) were enrolled. Blood samples were collected from all participants. Relative 
      expression of miR-146a/b was determined by real-time polymerase chain reaction. 
      Tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), interleukin-6 (IL-6), 
      interleukin-8 (IL-8), leukotriene B4 (LTB-4) expression in serum from AECOPD and 
      stable COPD patients were assessed using commercial ELISA kit.Serum levels of 
      miR-146a and miR-146b were down regulated in AECOPD patients compared with stable 
      COPD patients and HCs. miR-146a and miR-146b are of good values for predicting 
      the risk of AECOPD in HCs with AUC of 0.702 and 0.715. Additionally, miR-146a and 
      miR-146b could distinguish AECOPD from stable COPD patients with AUC of 0.670 and 
      0.643. In AECOPD patients, levels of miR-146a in AECOPD patients were negatively 
      associated with TNF-alpha, IL-6, IL-8, and LTE-4 expression. In stable COPD patients, 
      miR-146a expressions were negatively correlated with TNF-alpha, IL-1beta, IL-6, IL-8, 
      and LTE-4 levels. And, the expressions of miR-146b in AECOPD patients were 
      negatively associated with IL-1beta and LTB-4 expression. While in stable COPD 
      patients, miR-146b expressions were only negatively correlated with TNF-alpha 
      level.In conclusion, miR-146a and miR-146b were negatively correlated with 
      inflammatory cytokines, and could be promising biomarkers for predicting the risk 
      of AECOPD in stable COPD patients and healthy individuals.
FAU - Chen, Bei-Bei
AU  - Chen BB
AD  - Department of Respiratory, The Central Hospital of Wuhan, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, China.
FAU - Li, Zhen-Hua
AU  - Li ZH
FAU - Gao, Shan
AU  - Gao S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Biomarkers)
RN  - 0 (CXCL8 protein, human)
RN  - 0 (Cytokines)
RN  - 0 (IL6 protein, human)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Interleukin-6)
RN  - 0 (Interleukin-8)
RN  - 0 (MIRN146 microRNA, human)
RN  - 0 (MicroRNAs)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 1HGW4DR56D (Leukotriene B4)
SB  - IM
MH  - Acute Disease
MH  - Aged
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Cytokines/*blood
MH  - *Disease Progression
MH  - Down-Regulation
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Interleukin-1beta/blood
MH  - Interleukin-6/blood
MH  - Interleukin-8/blood
MH  - Leukotriene B4/blood
MH  - Male
MH  - MicroRNAs/*blood
MH  - Middle Aged
MH  - Pulmonary Disease, Chronic Obstructive/*blood
MH  - Real-Time Polymerase Chain Reaction
MH  - Risk Factors
MH  - Tumor Necrosis Factor-alpha/blood
PMC - PMC5839872
COIS- Conflicts of Interest: The authors have no conflicts of interest to disclose.
EDAT- 2018/02/15 06:00
MHDA- 2018/02/23 06:00
PMCR- 2018/02/16
CRDT- 2018/02/15 06:00
PHST- 2018/02/15 06:00 [entrez]
PHST- 2018/02/15 06:00 [pubmed]
PHST- 2018/02/23 06:00 [medline]
PHST- 2018/02/16 00:00 [pmc-release]
AID - 00005792-201802160-00017 [pii]
AID - MD-D-17-02963 [pii]
AID - 10.1097/MD.0000000000009820 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2018 Feb;97(7):e9820. doi: 10.1097/MD.0000000000009820.