PMID- 29445689
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1016-1430 (Print)
IS  - 2251-6840 (Electronic)
IS  - 1016-1430 (Linking)
VI  - 31
DP  - 2017
TI  - The effect of 3,4- methylenedioxymethamphetamine on expression of neurotrophic 
      factors in hippocampus of male rats.
PG  - 60
LID - 10.14196/mjiri.31.60 [doi]
AB  - Background: 3,4- methylenedioxymethamphetamine (MDMA) is a chemical derivative of 
      amphetamine that can induce learning and memory impairment. Due to the effect of 
      neurotrophins on memory and learning, the impact of MDMA was evaluated on the 
      brain - derived neurotrophic factor (BDNF), neurotrophin- 4 (NT-4), and 
      tropomyosin- related kinase B (Trk- beta) expression in the hippocampus. Methods: In 
      this study, 20 adult male Wistar rats (200-250 g) received saline (1 mL) or 10 
      mg/kg of MDMA intraperitoneally as single or multiple injection for 2 consecutive 
      days per week for 2 months. Expression of BDNF, Trk-beta, and NT4 were assessed 
      using Western blotting and RT PCR methods. Results: Our results revealed that the 
      expression of BDNF, Trk- beta, and NT4 proteins and genes significantly decreased in 
      MDMA groups compared to the sham group (p<0.05). Furthermore, the acute group 
      showed the lowest expression of these proteins. Conclusion: The results of the 
      present study suggest that ecstasy administration may downregulate the expression 
      of BDNF, Trk- beta, and NT-4 in hippocampus, which is more extensive in case of 
      acute treatment. It seems that in the chronic group, hippocampus was able to 
      compensate the ecstasy- induced neurotoxicity.
FAU - Soleimani Asl, Sara
AU  - Soleimani Asl S
AD  - Research Center for Behavioral Disorders and Substance Abuse, Hamadan University 
      of Medical Sciences, Hamadan, Iran.
AD  - Anatomy Department, School of Medicine, Hamadan University of Medical Sciences, 
      Hamadan, Iran.
FAU - Hesam Shariati, Mohamad Bakhtiar
AU  - Hesam Shariati MB
AD  - Research Center for Behavioral Disorders and Substance Abuse, Hamadan University 
      of Medical Sciences, Hamadan, Iran.
FAU - Medizadeh, Mehdi
AU  - Medizadeh M
AD  - Cellular & Molecular Research Center, Faculty of Advanced Technology in Medicine, 
      Department of Anatomical Sciences, Iran University of Medical Sciences, Tehran, 
      Iran.
FAU - Ahmadpanah, Mohammad
AU  - Ahmadpanah M
AD  - Research Center for Behavioral Disorders and Substance Abuse, Hamadan University 
      of Medical Sciences, Hamadan, Iran.
FAU - Sohrabi, Maryam
AU  - Sohrabi M
AD  - Anatomy Department, School of Medicine, Hamadan University of Medical Sciences, 
      Hamadan, Iran.
LA  - eng
PT  - Journal Article
DEP - 20170910
PL  - Iran
TA  - Med J Islam Repub Iran
JT  - Medical journal of the Islamic Republic of Iran
JID - 8910777
PMC - PMC5804417
OTO - NOTNLM
OT  - BDNF
OT  - Ecstasy
OT  - NT4
OT  - Trk- beta
EDAT- 2018/02/16 06:00
MHDA- 2018/02/16 06:01
PMCR- 2017/09/10
CRDT- 2018/02/16 06:00
PHST- 2016/12/07 00:00 [received]
PHST- 2018/02/16 06:00 [entrez]
PHST- 2018/02/16 06:00 [pubmed]
PHST- 2018/02/16 06:01 [medline]
PHST- 2017/09/10 00:00 [pmc-release]
AID - 10.14196/mjiri.31.60 [doi]
PST - epublish
SO  - Med J Islam Repub Iran. 2017 Sep 10;31:60. doi: 10.14196/mjiri.31.60. eCollection 
      2017.