PMID- 29446476
OWN - NLM
STAT- MEDLINE
DCOM- 20190415
LR  - 20210208
IS  - 1096-9071 (Electronic)
IS  - 0146-6615 (Linking)
VI  - 90
IP  - 6
DP  - 2018 Jun
TI  - The role of human papillomavirus in laryngeal cancer in Southern China.
PG  - 1150-1159
LID - 10.1002/jmv.25058 [doi]
AB  - To delineate the role of human papillomavirus (HPV) in laryngeal cancer in 
      Southern Chinese, a retrospective cross-sectional study was conducted in a major 
      otorhinolaryngology referral center in Hong Kong. Eighty-five Chinese patients 
      with histology-confirmed laryngeal squamous cell carcinoma (LSCC) diagnosed 
      between 2005 and 2010 were examined for the status of HPV by PCR, and the 
      expression of p16 and p53 by immunohistochemistry. The HPV, p16 and p53 findings 
      were correlated with clinicopathological features, recurrence and 5-year 
      survival. HPV DNA was detected in one patient (1.2%, 95%CI: 0.2-6.4%) who had 
      glottic cancer and harbored HPV-6. Overexpression of p16 and p53 were detected in 
      11 (12.9%) and 47 (55.3%) cases, respectively. Recurrence occurred in 22.4% of 
      patients at a median of 13 months. The 5-year overall survival and 
      disease-specific survival were 55.7% and 72.4%, respectively. Overexpression of 
      p16 or p53 was not associated with clinicopathological features, recurrence or 
      overall survival. HPV plays a limited role in laryngeal cancer in Hong Kong 
      Southern Chinese. In contrast to oropharyngeal cancer, p16 cannot be used as a 
      surrogate marker for oncogenic involvement of HPV and cannot predict survival in 
      laryngeal cancer.
CI  - (c) 2018 Wiley Periodicals, Inc.
FAU - Lam, Eddy W H
AU  - Lam EWH
AD  - Department of Otorhinolaryngology, Head & Neck Surgery, Yan Chai Hospital, Hong 
      Kong Special Administrative Region, People's Republic of China.
FAU - Chan, Michael M H
AU  - Chan MMH
AD  - Department of Otorhinolaryngology, Head & Neck Surgery, Yan Chai Hospital, Hong 
      Kong Special Administrative Region, People's Republic of China.
FAU - Wai, Cynthia K C
AU  - Wai CKC
AD  - Department of Otorhinolaryngology, Head & Neck Surgery, Yan Chai Hospital, Hong 
      Kong Special Administrative Region, People's Republic of China.
FAU - Ngai, Chi Man
AU  - Ngai CM
AD  - Department of Otorhinolaryngology, Head & Neck Surgery, Yan Chai Hospital, Hong 
      Kong Special Administrative Region, People's Republic of China.
FAU - Chen, Zigui
AU  - Chen Z
AD  - Department of Microbiology, Faculty of Medicine, The Chinese University of Hong 
      Kong, Hong Kong Special Administrative Region, People's Republic of China.
FAU - Wong, Martin C S
AU  - Wong MCS
AD  - Jockey Club School of Public Health and Primary Care, Faculty of Medicine, The 
      Chinese University of Hong Kong, Hong Kong Special Administrative Region, 
      People's Republic of China.
FAU - Yeung, Apple C M
AU  - Yeung ACM
AD  - Department of Microbiology, Faculty of Medicine, The Chinese University of Hong 
      Kong, Hong Kong Special Administrative Region, People's Republic of China.
FAU - Tong, Joanna H M
AU  - Tong JHM
AD  - Department of Anatomical and Cellular Pathology, Faculty of Medicine, The Chinese 
      University of Hong Kong, Hong Kong Special Administrative Region, People's 
      Republic of China.
FAU - Chan, Amy B W
AU  - Chan ABW
AD  - Department of Anatomical and Cellular Pathology, Faculty of Medicine, The Chinese 
      University of Hong Kong, Hong Kong Special Administrative Region, People's 
      Republic of China.
FAU - To, Ka-Fai
AU  - To KF
AD  - Department of Anatomical and Cellular Pathology, Faculty of Medicine, The Chinese 
      University of Hong Kong, Hong Kong Special Administrative Region, People's 
      Republic of China.
FAU - Chan, Paul K S
AU  - Chan PKS
AUID- ORCID: 0000-0002-6360-4608
AD  - Department of Microbiology, Faculty of Medicine, The Chinese University of Hong 
      Kong, Hong Kong Special Administrative Region, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20180306
PL  - United States
TA  - J Med Virol
JT  - Journal of medical virology
JID - 7705876
RN  - 0 (CDKN2A protein, human)
RN  - 0 (Cyclin-Dependent Kinase Inhibitor p16)
RN  - 0 (DNA, Viral)
RN  - 0 (Tumor Suppressor Protein p53)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Squamous Cell/*epidemiology/pathology/*virology
MH  - Cross-Sectional Studies
MH  - Cyclin-Dependent Kinase Inhibitor p16/analysis
MH  - DNA, Viral/analysis/genetics
MH  - Female
MH  - Hong Kong/epidemiology
MH  - Humans
MH  - Immunohistochemistry
MH  - Laryngeal Neoplasms/*epidemiology/pathology/*virology
MH  - Male
MH  - Middle Aged
MH  - Papillomaviridae/*classification/*isolation & purification
MH  - Polymerase Chain Reaction
MH  - Recurrence
MH  - Retrospective Studies
MH  - Survival Analysis
MH  - Tumor Suppressor Protein p53/analysis
OTO - NOTNLM
OT  - Hong Kong
OT  - Laryngeal cancer
OT  - Southern Chinese
OT  - human papillomavirus (HPV)
OT  - p16
EDAT- 2018/02/16 06:00
MHDA- 2019/04/16 06:00
CRDT- 2018/02/16 06:00
PHST- 2017/09/20 00:00 [received]
PHST- 2018/02/01 00:00 [revised]
PHST- 2018/02/02 00:00 [accepted]
PHST- 2018/02/16 06:00 [pubmed]
PHST- 2019/04/16 06:00 [medline]
PHST- 2018/02/16 06:00 [entrez]
AID - 10.1002/jmv.25058 [doi]
PST - ppublish
SO  - J Med Virol. 2018 Jun;90(6):1150-1159. doi: 10.1002/jmv.25058. Epub 2018 Mar 6.