PMID- 29446659
OWN - NLM
STAT- MEDLINE
DCOM- 20181011
LR  - 20221207
IS  - 1945-0257 (Electronic)
IS  - 1945-0257 (Linking)
VI  - 22
IP  - 3
DP  - 2018 Mar
TI  - Association Analysis of the Brain-Derived Neurotrophic Factor Gene Val66Met 
      Polymorphism and Gender with Efficacy of Antidepressants in the Chinese Han 
      Population with Generalized Anxiety Disorder.
PG  - 199-206
LID - 10.1089/gtmb.2017.0053 [doi]
AB  - BACKGROUND AND AIM: This study was designed to explore the relationship between 
      the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and 
      antidepressants' efficacy in the Chinese Han population with generalized anxiety 
      disorder (GAD). MATERIALS AND METHODS: We recruited 206 patients who met the 
      diagnostic criteria for GAD into the test group, and assigned 209 healthy 
      participants to the control group. All participants were genotyped for the BDNF 
      Val66Met polymorphism. GAD patients were treated with escitalopram or 
      extended-release venlafaxine. We used the Hamilton Rating Scale for Anxiety 
      (HAM-A) to assess the response to 8-weeks of antidepressant treatment for GAD. 
      RESULTS: We did not identify any significant differences in the allelic or 
      genotype frequencies of the BDNF Val66Met polymorphism between the test and 
      control group. Furthermore, we did not detect any significant difference in the 
      allele or genotype frequency of BDNF Val66Met between patients with different 
      treatment responses. Finally, we did not detect any significant difference in the 
      HAM-A score reduction rate among patients with different genotypes, gender, or 
      treatment drugs. CONCLUSIONS: No significant difference was found in the BDNF 
      Val66Met polymorphism between patients with GAD and healthy controls, nor was 
      this polymorphism significantly associated with antidepressant drug efficacy for 
      GAD.
FAU - Lin, Min
AU  - Lin M
AD  - 1 Department of Clinical Psychology, Huzhou 3rd Hospital , Huzhou, P.R. China .
FAU - Zhu, Jianying
AU  - Zhu J
AD  - 2 Department of Radiology, Huzhou 3rd Hospital , Huzhou, P.R. China .
FAU - Yuan, Yonggui
AU  - Yuan Y
AD  - 3 Department of Psychosomatics and Psychiatry, Affiliated ZhongDa Hospital of 
      Southeast University , Nanjing, P.R. China .
FAU - Ren, Lie
AU  - Ren L
AD  - 4 Department of Neurosis and Psychosomatic Diseases, Huzhou 3rd Hospital , 
      Huzhou, P.R. China .
FAU - Qian, Mincai
AU  - Qian M
AD  - 4 Department of Neurosis and Psychosomatic Diseases, Huzhou 3rd Hospital , 
      Huzhou, P.R. China .
FAU - Shen, Zhongxia
AU  - Shen Z
AD  - 4 Department of Neurosis and Psychosomatic Diseases, Huzhou 3rd Hospital , 
      Huzhou, P.R. China .
FAU - Shao, Yongliang
AU  - Shao Y
AD  - 2 Department of Radiology, Huzhou 3rd Hospital , Huzhou, P.R. China .
FAU - Shen, Xinhua
AU  - Shen X
AD  - 4 Department of Neurosis and Psychosomatic Diseases, Huzhou 3rd Hospital , 
      Huzhou, P.R. China .
LA  - eng
PT  - Journal Article
DEP - 20180215
PL  - United States
TA  - Genet Test Mol Biomarkers
JT  - Genetic testing and molecular biomarkers
JID - 101494210
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Adult
MH  - Antidepressive Agents/*therapeutic use
MH  - Anxiety/*drug therapy/ethnology/*genetics
MH  - Asian People/*genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - China
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Methionine/*genetics
MH  - Middle Aged
MH  - Patient Health Questionnaire
MH  - *Polymorphism, Single Nucleotide
MH  - Treatment Outcome
MH  - Valine/*genetics
OTO - NOTNLM
OT  - antidepressant efficacy
OT  - brain-derived neurotrophic factor
OT  - generalized anxiety disorder
OT  - single nucleotide polymorphism
EDAT- 2018/02/16 06:00
MHDA- 2018/10/12 06:00
CRDT- 2018/02/16 06:00
PHST- 2018/02/16 06:00 [pubmed]
PHST- 2018/10/12 06:00 [medline]
PHST- 2018/02/16 06:00 [entrez]
AID - 10.1089/gtmb.2017.0053 [doi]
PST - ppublish
SO  - Genet Test Mol Biomarkers. 2018 Mar;22(3):199-206. doi: 10.1089/gtmb.2017.0053. 
      Epub 2018 Feb 15.