PMID- 29447739 OWN - NLM STAT- MEDLINE DCOM- 20190716 LR - 20220409 IS - 1558-3597 (Electronic) IS - 0735-1097 (Linking) VI - 71 IP - 7 DP - 2018 Feb 20 TI - Native T1 and ECV of Noninfarcted Myocardium and Outcome in Patients With Coronary Artery Disease. PG - 766-778 LID - S0735-1097(17)41936-X [pii] LID - 10.1016/j.jacc.2017.12.020 [doi] AB - BACKGROUND: Coronary artery disease (CAD) remains the major cause of cardiac morbidity and mortality worldwide, despite the advances in treatment with coronary revascularization and modern antiremodeling therapy. Risk stratification in CAD patients is primarily based on left ventricular volumes, ejection fraction (LVEF), risk scores, and the presence and extent of late gadolinium enhancement (LGE). The prognostic role of T1 mapping in noninfarcted myocardium in CAD patients has not yet been determined. OBJECTIVES: This study sought to examine prognostic significance of native T1 mapping of noninfarcted myocardium in patients with CAD. METHODS: A prospective, observational, multicenter longitudinal study of consecutive patients undergoing routine cardiac magnetic resonance imaging with T1 mapping and LGE. The primary endpoint was all-cause mortality. Major adverse cardiocerebrovascular events (MACCE) (cardiac mortality, nonfatal acute coronary syndrome, stroke, and appropriate device discharge) are also reported. RESULTS: A total of 34 deaths and 71 MACCE (n = 665, males n = 424, median age [interquartile range] 57 [22] years; 64%; median follow-up period of 17 [11] months) were observed. Native T1 and extracellular volume were univariate predictors of outcome. Native T1 and LGE were stronger predictors of survival and MACCE compared with extracellular volume, LVEF, cardiac volumes, and clinical scores (p < 0.001). Native T1 of noninfarcted myocardium was the sole independent predictor of all-cause mortality (chi-square = 21.7; p < 0.001), which was accentuated in the absence of LGE or LVEF