PMID- 29448052 OWN - NLM STAT- MEDLINE DCOM- 20181105 LR - 20221207 IS - 1879-1166 (Electronic) IS - 0198-8859 (Linking) VI - 79 IP - 4 DP - 2018 Apr TI - KIR and HLA ligands demonstrate genetic inheritance diversity in Japanese descendants from Parana, Brazil. PG - 191-192 LID - S0198-8859(18)30042-9 [pii] LID - 10.1016/j.humimm.2018.02.005 [doi] AB - In order to investigate killer immunoglobulin-like receptors (KIR) and their ligands, human leukocyte antigen (HLA), diversity in the Brazilian population influenced by migrations, unrelated Brazilian Japanese descendants were selected and genotyped for the KIR genes and HLA class I allele groups. Genetic heterogeneity in Brazil Parana Japanese was observed for KIR genes, whose frequency distributions demonstrated similarity with mixed Brazilian populations and with the Japanese population, suggesting gene flow. The data contributed to the identification of the genetic constitution of the Brazilian population influenced by immigrations and two new genotypes were defined. CI - Copyright (c) 2018 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved. FAU - de Alencar, Josiane Bazzo AU - de Alencar JB AD - Department of Clinical Analysis and Biomedicine, Post Graduation Program in Biosciences and Physiopathology, State University of Maringa, Maringa, Parana, Brazil. Electronic address: josibazzo@gmail.com. FAU - Zacarias, Joana Maira Valentini AU - Zacarias JMV AD - Department of Clinical Analysis and Biomedicine, Post Graduation Program in Biosciences and Physiopathology, State University of Maringa, Maringa, Parana, Brazil. FAU - Moura, Barbara Leticia da Silva Guedes de AU - Moura BLDSG AD - Department of Clinical Analysis and Biomedicine, Post Graduation Program in Biosciences and Physiopathology, State University of Maringa, Maringa, Parana, Brazil. FAU - Braga, Marco Antonio AU - Braga MA AD - Laboratory of Immunogenetics, Department of Basic Health Sciences, State University of Maringa, UEM, Maringa, Parana, Brazil. FAU - Visentainer, Jeane Eliete Laguila AU - Visentainer JEL AD - Department of Clinical Analysis and Biomedicine, Post Graduation Program in Biosciences and Physiopathology, State University of Maringa, Maringa, Parana, Brazil; Laboratory of Immunogenetics, Department of Basic Health Sciences, State University of Maringa, UEM, Maringa, Parana, Brazil. FAU - Sell, Ana Maria AU - Sell AM AD - Department of Clinical Analysis and Biomedicine, Post Graduation Program in Biosciences and Physiopathology, State University of Maringa, Maringa, Parana, Brazil; Laboratory of Immunogenetics, Department of Basic Health Sciences, State University of Maringa, UEM, Maringa, Parana, Brazil. Electronic address: amsell@uem.br. LA - eng PT - Journal Article DEP - 20180212 PL - United States TA - Hum Immunol JT - Human immunology JID - 8010936 RN - 0 (HLA Antigens) RN - 0 (Receptors, KIR) SB - IM MH - Alleles MH - Asian People/*genetics MH - Brazil MH - Gene Flow/*genetics MH - Genetic Variation MH - HLA Antigens/*genetics MH - *Human Migration MH - Humans MH - Receptors, KIR/*genetics OTO - NOTNLM OT - Asian continental ancestry group OT - Gene frequency OT - Genotyping techniques OT - HLA antigens OT - Haplotypes OT - KIR receptors EDAT- 2018/02/16 06:00 MHDA- 2018/11/06 06:00 CRDT- 2018/02/16 06:00 PHST- 2017/12/18 00:00 [received] PHST- 2018/02/05 00:00 [revised] PHST- 2018/02/08 00:00 [accepted] PHST- 2018/02/16 06:00 [pubmed] PHST- 2018/11/06 06:00 [medline] PHST- 2018/02/16 06:00 [entrez] AID - S0198-8859(18)30042-9 [pii] AID - 10.1016/j.humimm.2018.02.005 [doi] PST - ppublish SO - Hum Immunol. 2018 Apr;79(4):191-192. doi: 10.1016/j.humimm.2018.02.005. Epub 2018 Feb 12.