PMID- 29448914 OWN - NLM STAT- MEDLINE DCOM- 20181022 LR - 20181113 IS - 1744-8069 (Electronic) IS - 1744-8069 (Linking) VI - 14 DP - 2018 Jan-Dec TI - Quantitative evaluation to efficacy and safety of therapies for psoriasis: A network meta-analysis. PG - 1744806918762205 LID - 10.1177/1744806918762205 [doi] LID - 1744806918762205 AB - Therapies treating psoriasis can be categorized into five classes according to their mechanism: anti-metabolites (AM), anti-interleukin-12/23 agents (anti-IL12/23), anti-interleukin-17 agents (anti-IL17), anti-T-cell agent (ANT), and anti-tumor necrosis factor-alpha agent (anti-TNF-alpha). This network meta-analysis (NMA) aimed to give a quantitative and systemic evaluation of safety and efficacy for the five kinds of therapies mentioned above. Odds ratios and mean differences were calculated to evaluate binary and continuous outcomes, respectively. Forest plots were conducted to show the performance of pair-wise comparison of above therapies in each outcome, and surface under the cumulative ranking curves was given to evaluate the relative ranking of above therapies in each outcome. Node splitting was conducted to evaluate the consistency between direct and indirect evidence. Direct comparisons from 65 studies (32,352 patients) were included in this NMA. Our results showed an excellent efficacy of anti-IL12/23 and anti-IL17. However, these two therapies and anti-TNF-alpha were revealed to have a high possibility to cause adverse effects (AEs) such as infections. Additionally, node splitting showed that no inconsistency appeared between the direct and indirect comparisons. Anti-IL12/23 was the most recommended therapy according to this NMA. Anti-IL17 had similar efficacy to anti-IL12/23 but should be applied with caution since it has poor performance in safety outcomes. FAU - Lv, Jingjing AU - Lv J AD - 1 Beijing Hospital of Traditional Chinese Medicine, Affiliated with Capital Medical University, Beijing Institute of Traditional Chinese Medicine, Beijing Key Laboratory of Clinic and Basic Research with TCM on Psoriasis, Beijing, China. FAU - Zhou, Dongmei AU - Zhou D AD - 2 Department of Dermatology, Beijing Hospital of Traditional Chinese Medicine, Affiliated with Capital Medical University, Beijing Institute of Traditional Chinese Medicine, Beijing, China. FAU - Wang, Yan AU - Wang Y AD - 1 Beijing Hospital of Traditional Chinese Medicine, Affiliated with Capital Medical University, Beijing Institute of Traditional Chinese Medicine, Beijing Key Laboratory of Clinic and Basic Research with TCM on Psoriasis, Beijing, China. FAU - Zhao, Jingxia AU - Zhao J AD - 1 Beijing Hospital of Traditional Chinese Medicine, Affiliated with Capital Medical University, Beijing Institute of Traditional Chinese Medicine, Beijing Key Laboratory of Clinic and Basic Research with TCM on Psoriasis, Beijing, China. FAU - Chen, Zhaoxia AU - Chen Z AD - 1 Beijing Hospital of Traditional Chinese Medicine, Affiliated with Capital Medical University, Beijing Institute of Traditional Chinese Medicine, Beijing Key Laboratory of Clinic and Basic Research with TCM on Psoriasis, Beijing, China. FAU - Zhang, Jinchao AU - Zhang J AD - 1 Beijing Hospital of Traditional Chinese Medicine, Affiliated with Capital Medical University, Beijing Institute of Traditional Chinese Medicine, Beijing Key Laboratory of Clinic and Basic Research with TCM on Psoriasis, Beijing, China. FAU - Di, Tingting AU - Di T AD - 1 Beijing Hospital of Traditional Chinese Medicine, Affiliated with Capital Medical University, Beijing Institute of Traditional Chinese Medicine, Beijing Key Laboratory of Clinic and Basic Research with TCM on Psoriasis, Beijing, China. FAU - Hu, Jing AU - Hu J AD - 1 Beijing Hospital of Traditional Chinese Medicine, Affiliated with Capital Medical University, Beijing Institute of Traditional Chinese Medicine, Beijing Key Laboratory of Clinic and Basic Research with TCM on Psoriasis, Beijing, China. FAU - Li, Bo AU - Li B AD - 1 Beijing Hospital of Traditional Chinese Medicine, Affiliated with Capital Medical University, Beijing Institute of Traditional Chinese Medicine, Beijing Key Laboratory of Clinic and Basic Research with TCM on Psoriasis, Beijing, China. FAU - Li, Ping AU - Li P AUID- ORCID: 0000-0002-6657-9807 AD - 1 Beijing Hospital of Traditional Chinese Medicine, Affiliated with Capital Medical University, Beijing Institute of Traditional Chinese Medicine, Beijing Key Laboratory of Clinic and Basic Research with TCM on Psoriasis, Beijing, China. FAU - Huang, Feng AU - Huang F AD - 1 Beijing Hospital of Traditional Chinese Medicine, Affiliated with Capital Medical University, Beijing Institute of Traditional Chinese Medicine, Beijing Key Laboratory of Clinic and Basic Research with TCM on Psoriasis, Beijing, China. LA - eng PT - Journal Article PT - Meta-Analysis PT - Research Support, Non-U.S. Gov't DEP - 20180215 PL - United States TA - Mol Pain JT - Molecular pain JID - 101242662 SB - IM MH - Adult MH - Female MH - Humans MH - Male MH - Middle Aged MH - *Network Meta-Analysis MH - Psoriasis/*therapy MH - Quality of Life MH - Randomized Controlled Trials as Topic MH - Severity of Illness Index MH - Treatment Outcome PMC - PMC5993069 OTO - NOTNLM OT - Psoriasis OT - efficacy OT - network meta-analysis OT - safety EDAT- 2018/02/17 06:00 MHDA- 2018/10/23 06:00 PMCR- 2018/02/15 CRDT- 2018/02/17 06:00 PHST- 2018/02/17 06:00 [pubmed] PHST- 2018/10/23 06:00 [medline] PHST- 2018/02/17 06:00 [entrez] PHST- 2018/02/15 00:00 [pmc-release] AID - 10.1177_1744806918762205 [pii] AID - 10.1177/1744806918762205 [doi] PST - ppublish SO - Mol Pain. 2018 Jan-Dec;14:1744806918762205. doi: 10.1177/1744806918762205. Epub 2018 Feb 15.