PMID- 29449058
OWN - NLM
STAT- MEDLINE
DCOM- 20180321
LR  - 20180321
IS  - 2213-0276 (Electronic)
IS  - 0755-4982 (Linking)
VI  - 47
IP  - 1
DP  - 2018 Jan
TI  - [Epidemiology of lower extremity artery disease].
PG  - 38-46
LID - S0755-4982(18)30013-7 [pii]
LID - 10.1016/j.lpm.2018.01.012 [doi]
AB  - It is estimated that more than 200 million individuals are affected by lower 
      extremity artery disease (LEAD) worldwide. This prevalence has increased between 
      2000 and 2010 by 25%, especially in low/middle income countries. In France, about 
      one million people are affected by this condition. Almost two-thirds of patients 
      with LEAD are asymptomatic. This explains the interest of the measurement of the 
      ankle-brachial index (ABI), an objective and harmless diagnostic tool. An 
      ABI</=0.90 is considered as diagnostic for LEAD. The detection of symptomatic LEAD 
      requires standardized questionnaires identifying intermittent claudication. 
      Epidemiological studies on chronic limb-threatening ischemia (CLTI) - the most 
      severe presentation of the disease - are scarce: the prevalence is estimated 
      around 0.5-2.0% after the age of 40, mostly affecting elderly people. Similar to 
      other atherosclerotic diseases, the risk factors are multiple (genetic factors, 
      traditional risk factors, metabolic and inflammatory factors, socioeconomic 
      factors), with different weighs of association as compared to coronary artery 
      diseases. Due to their high prevalence and strength of association, cigarette 
      smoking and hypertension are the most frequent purveyors of this disease in 
      population. Diabetes mellitus is a strong risk factor, and its increasing 
      prevalence contributes to the global epidemics of LEAD. In claudicants, the 
      5-year amputation risk is estimated at 5%, increasing to 25% at one year in case 
      of CLTI. However, the main risk is related to general cardiovascular events. It 
      is estimated that patients with LEAD present concomitantly coronary and 
      cerebrovascular disease in respectively 50% and 20% of cases. The 
      non-cardiovascular mortality, especially related to cancer, is also higher than 
      in general population. Overall, the control of traditional risk factors has a 
      beneficial effect both for the limb and general prognosis.
CI  - Copyright (c) 2018. Published by Elsevier Masson SAS.
FAU - Aboyans, Victor
AU  - Aboyans V
AD  - CHU de Limoges, service de cardiologie, 87042 Limoges, France; Faculte de 
      medecine, Inserm U1094, 87025 Limoges, France. Electronic address: 
      victor.aboyans@unilim.fr.
FAU - Sevestre, Marie-Antoinette
AU  - Sevestre MA
AD  - CHU d'Amiens, service de medecine vasculaire, 80054 Amiens, France.
FAU - Desormais, Ileana
AU  - Desormais I
AD  - Faculte de medecine, Inserm U1094, 87025 Limoges, France; CHU de Limoges, service 
      de chirurgie thoracique et vasculaire et medecine vasculaire, 87042 Limoges, 
      France.
FAU - Lacroix, Philippe
AU  - Lacroix P
AD  - Faculte de medecine, Inserm U1094, 87025 Limoges, France; CHU de Limoges, service 
      de chirurgie thoracique et vasculaire et medecine vasculaire, 87042 Limoges, 
      France.
FAU - Fowkes, Gerry
AU  - Fowkes G
AD  - Usher institute of population health sciences and informatics, Edimbourg, 
      Royaume-Uni.
FAU - Criqui, Michael H
AU  - Criqui MH
AD  - University of California, department of family medicine and public health, San 
      Diego, La Jolla, CA, Etats-Unis.
LA  - fre
PT  - Journal Article
PT  - Review
TT  - Epidemiologie de l'arteriopathie des membres inferieurs.
DEP - 20180212
PL  - France
TA  - Presse Med
JT  - Presse medicale (Paris, France : 1983)
JID - 8302490
SB  - IM
MH  - Aged
MH  - Cardiovascular Diseases/epidemiology
MH  - Cigarette Smoking/epidemiology
MH  - Comorbidity
MH  - Diabetes Mellitus/epidemiology
MH  - Dyslipidemias/epidemiology
MH  - Female
MH  - France/epidemiology
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Hypertension/epidemiology
MH  - Incidence
MH  - Inflammation/epidemiology
MH  - Intermittent Claudication/epidemiology
MH  - Ischemia/epidemiology
MH  - Leg/*blood supply
MH  - Male
MH  - Middle Aged
MH  - Neoplasms/epidemiology
MH  - Peripheral Arterial Disease/*epidemiology
MH  - Prevalence
MH  - Prognosis
MH  - Risk Factors
MH  - Socioeconomic Factors
EDAT- 2018/02/17 06:00
MHDA- 2018/03/22 06:00
CRDT- 2018/02/17 06:00
PHST- 2018/02/17 06:00 [pubmed]
PHST- 2018/03/22 06:00 [medline]
PHST- 2018/02/17 06:00 [entrez]
AID - S0755-4982(18)30013-7 [pii]
AID - 10.1016/j.lpm.2018.01.012 [doi]
PST - ppublish
SO  - Presse Med. 2018 Jan;47(1):38-46. doi: 10.1016/j.lpm.2018.01.012. Epub 2018 Feb 
      12.