PMID- 29449140
OWN - NLM
STAT- MEDLINE
DCOM- 20190207
LR  - 20220410
IS  - 1525-5069 (Electronic)
IS  - 1525-5050 (Linking)
VI  - 80
DP  - 2018 Mar
TI  - Effectiveness of a multicomponent self-management intervention for adults with 
      epilepsy (ZMILE study): A randomized controlled trial.
PG  - 259-265
LID - S1525-5050(17)31060-0 [pii]
LID - 10.1016/j.yebeh.2018.01.019 [doi]
AB  - BACKGROUND: The objective of the ZMILE study was to compare the effectiveness of 
      a multicomponent self-management intervention (MCI) with care as usual (CAU) in 
      adult patients with epilepsy (PWE) over a six-month period. METHODS: Participants 
      (PWE & relative) were randomized into intervention or CAU groups. Self-report 
      questionnaires were used to measure disease-specific self-efficacy as the primary 
      outcome measure and general self-efficacy, adherence, seizure severity, emotional 
      functioning, quality of life, proactive coping, and side-effects of antiepileptic 
      drugs (AED) as secondary outcome measures. Instruments used at baseline and 
      during a six-month follow-up period were the following: disease-specific 
      self-efficacy (Epilepsy Self-Efficacy Scale [ESES], General Self-Efficacy Scale 
      [GSES]); adherence (Medication Adherence Scale [MARS] and Medication Event 
      Monitoring System [MEMS]); seizure severity (National Hospital Seizure Severity 
      Scale [NHS3]); emotional well-being (Hospital Anxiety and Depression Scale 
      [HADS]); quality of life (Quality of Life in Epilepsy [QOLIE-31P]); proactive 
      coping (Utrecht Proactive Coping Competence [UPCC]); and side-effects of 
      antiepileptic drugs [SIDAED]. Multilevel analyses were performed, and baseline 
      differences were corrected by inclusion of covariates in the analyses. RESULTS: 
      In total, 102 PWE were included in the study, 52 of whom were in the intervention 
      group. On the SIDAED and on three of the quality of life subscales QOLIE-31P, a 
      significant difference was found (p<0.05) in the intervention group. 
      Self-efficacy, however, showed no significant differences between the MCI and the 
      CAU groups. None of the other outcome measures showed any significant difference 
      between the two groups. SIGNIFICANCE: Although we found no statistically 
      significant difference in the primary outcome measure, disease-specific 
      self-efficacy, this MCI could prove promising, since we found improvement in some 
      domains of quality of life in epilepsy scale and a decrease in AED side-effects 
      in the MCI group compared with the CAU group.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Leenen, Loes A M
AU  - Leenen LAM
AD  - Faculty of Health, Medicine and Life Sciences, Department of Health Services 
      Research, CAPHRI Care and Public Health Institute, Maastricht University, 
      Maastricht, The Netherlands; Department of Research & Development, Academic 
      Centre for Epileptology Kempenhaeghe Maastricht UMC+, The Netherlands; Department 
      of Neurology, Academic Centre for Epileptology Kempenhaeghe Maastricht UMC+, The 
      Netherlands. Electronic address: leenenl@kempenhaeghe.nl.
FAU - Wijnen, Ben F M
AU  - Wijnen BFM
AD  - Faculty of Health, Medicine and Life Sciences, Department of Health Services 
      Research, CAPHRI Care and Public Health Institute, Maastricht University, 
      Maastricht, The Netherlands; Department of Research & Development, Academic 
      Centre for Epileptology Kempenhaeghe Maastricht UMC+, The Netherlands. Electronic 
      address: b.wijnen@maastrichtuniversity.nl.
FAU - Kessels, Alfons G H
AU  - Kessels AGH
AD  - Faculty of Health, Medicine and Life Sciences, Department of Health Services 
      Research, CAPHRI Care and Public Health Institute, Maastricht University, 
      Maastricht, The Netherlands. Electronic address: 
      fons.kessels@maastrichtuniversity.nl.
FAU - Chan, HoiYau
AU  - Chan H
AD  - Faculty of Health, Medicine and Life Sciences, Department of Health Services 
      Research, CAPHRI Care and Public Health Institute, Maastricht University, 
      Maastricht, The Netherlands. Electronic address: h.chan@maastrichtuniversity.nl.
FAU - de Kinderen, Reina J A
AU  - de Kinderen RJA
AD  - Trimbos Institute, Netherlands Institute of Mental Health and Addiction, Utrecht, 
      The Netherlands. Electronic address: RKinderen@trimbos.nl.
FAU - Evers, Silvia M A A
AU  - Evers SMAA
AD  - Faculty of Health, Medicine and Life Sciences, Department of Health Services 
      Research, CAPHRI Care and Public Health Institute, Maastricht University, 
      Maastricht, The Netherlands; Trimbos Institute, Netherlands Institute of Mental 
      Health and Addiction, Utrecht, The Netherlands. Electronic address: 
      s.evers@maastrichtuniversity.nl.
FAU - van Heugten, Caroline M
AU  - van Heugten CM
AD  - School for Mental Health and Neuroscience (MHENS), Maastricht University Medical 
      Centre, Maastricht, The Netherlands; Faculty of Psychology and Neurosciences: 
      Department of Neuropsychology and Psychopharmacology, Maastricht University, 
      Maastricht, The Netherlands. Electronic address: 
      c.vanheugten@maastrichtuniversity.nl.
FAU - Majoie, Marian H J M
AU  - Majoie MHJM
AD  - Department of Research & Development, Academic Centre for Epileptology 
      Kempenhaeghe Maastricht UMC+, The Netherlands; Department of Neurology, Academic 
      Centre for Epileptology Kempenhaeghe Maastricht UMC+, The Netherlands; School for 
      Mental Health and Neuroscience (MHENS), Maastricht University Medical Centre, 
      Maastricht, The Netherlands; School of Health Professions Education, Faculty of 
      Health, Medicine and Life Sciences, Maastricht University, Maastricht, The 
      Netherlands. Electronic address: majoiem@kempenhaeghe.nl.
LA  - eng
SI  - NTR/NTR4484
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20180212
PL  - United States
TA  - Epilepsy Behav
JT  - Epilepsy & behavior : E&B
JID - 100892858
RN  - 0 (Anticonvulsants)
SB  - IM
MH  - Adaptation, Psychological
MH  - Adult
MH  - Aged
MH  - Anticonvulsants/therapeutic use
MH  - Emotions
MH  - Epilepsy/psychology/*therapy
MH  - Female
MH  - Humans
MH  - Male
MH  - *Medication Adherence
MH  - Middle Aged
MH  - Outcome Assessment, Health Care
MH  - Patient Education as Topic/*methods
MH  - Quality of Life/*psychology
MH  - Seizures/drug therapy
MH  - *Self Efficacy
MH  - Self-Management/*methods
MH  - Surveys and Questionnaires
MH  - Young Adult
OTO - NOTNLM
OT  - Epilepsy
OT  - Goal-setting
OT  - Group intervention
OT  - Multicomponent intervention
OT  - PWE & relative
OT  - Self-efficacy
OT  - Self-management
EDAT- 2018/02/17 06:00
MHDA- 2019/02/08 06:00
CRDT- 2018/02/17 06:00
PHST- 2017/12/18 00:00 [received]
PHST- 2018/01/15 00:00 [revised]
PHST- 2018/01/17 00:00 [accepted]
PHST- 2018/02/17 06:00 [pubmed]
PHST- 2019/02/08 06:00 [medline]
PHST- 2018/02/17 06:00 [entrez]
AID - S1525-5050(17)31060-0 [pii]
AID - 10.1016/j.yebeh.2018.01.019 [doi]
PST - ppublish
SO  - Epilepsy Behav. 2018 Mar;80:259-265. doi: 10.1016/j.yebeh.2018.01.019. Epub 2018 
      Feb 12.