PMID- 29449347
OWN - NLM
STAT- MEDLINE
DCOM- 20190415
LR  - 20221207
IS  - 1573-4935 (Electronic)
IS  - 0144-8463 (Print)
IS  - 0144-8463 (Linking)
VI  - 38
IP  - 4
DP  - 2018 Aug 31
TI  - Association of tumor necrosis factor-alpha (TNF-alpha) gene promoter polymorphisms with 
      aggressive and chronic periodontitis in the eastern Indian population.
LID - BSR20171212 [pii]
LID - 10.1042/BSR20171212 [doi]
AB  - Background: Periodontitis is a very common inflammatory oral disease. Tumor 
      necrosis factor-alpha (TNF-alpha) is a cytokine that has been involved with the gingival 
      tissue destruction and remodeling occurrence. We investigated the association of 
      single nucleotide polymorphisms (SNPs) in TNF-alpha gene promoter region with the 
      susceptibility of aggressive and chronic periodontitis in the eastern Indian 
      population.Methods: A total of 397 DNA samples from venous blood were isolated. 
      40 individuals were aggressive periodontitis patients, 157 were identified 
      chronic periodontitis patients, and the remaining 200 were healthy individuals. 
      Five SNPs of TNF-alpha at promoter region (rs361525, rs1800629, rs1799724, rs1800630, 
      and rs1799964) were genotyped by PCR-sequencing in periodontitis patients and 
      control subjects.Results: rs1800629 (-308G/A) polymorphism was more frequent in 
      both aggressive and chronic periodontitis patients compared with the control 
      population, though the allele frequency was different only in aggressive 
      periodontitis patients. On the other hand, both the genotypic and allelic 
      variation of rs361525 (-238G/A) polymorphism were found significantly less 
      frequently in aggressive and chronic periodontitis than in controls. The other 
      polymorphisms like rs1799724 (-857C/T) and rs1799964 (-1031T/C) were 
      significantly different between chronic periodontitis patients and control 
      subjects.Conclusion: The findings suggest that the rs1800629 (-308G/A) 
      polymorphism of TNF-alpha gene is associated with both aggressive and chronic 
      periodontitis while rs1799724 (-857C/T) and rs1799964 (-1031T/C) polymorphisms of 
      TNF-alpha gene is associated only with the increased susceptibility to chronic 
      periodontitis.
CI  - (c) 2018 The Author(s).
FAU - Majumder, Poulami
AU  - Majumder P
AD  - Department of Biotechnology, Centre for Genetic studies, School of Biotechnology 
      and Biological Sciences, West Bengal University of Technology, BF-142, Sector I, 
      Salt Lake City, Kolkata, West Bengal 70064, India.
FAU - Thou, Keheibamding
AU  - Thou K
AD  - Department of Biotechnology, Centre for Genetic studies, School of Biotechnology 
      and Biological Sciences, West Bengal University of Technology, BF-142, Sector I, 
      Salt Lake City, Kolkata, West Bengal 70064, India.
FAU - Bhattacharya, Mandar
AU  - Bhattacharya M
AD  - Department of Biotechnology, Centre for Genetic studies, School of Biotechnology 
      and Biological Sciences, West Bengal University of Technology, BF-142, Sector I, 
      Salt Lake City, Kolkata, West Bengal 70064, India.
FAU - Nair, Vineet
AU  - Nair V
AD  - Department of Periodontia, North Bengal Dental College, Siliguri, West Bengal, 
      734012, India.
FAU - Ghosh, Sujay
AU  - Ghosh S
AD  - Department of Zoology, Cytogenetics and Genomics Research Unit, University of 
      Calcutta, 35 Ballygunge Circular Road, Kolkata, West Bengal 700019, India.
FAU - Dey, Subrata Kumar
AU  - Dey SK
AD  - Department of Biotechnology, Centre for Genetic studies, School of Biotechnology 
      and Biological Sciences, West Bengal University of Technology, BF-142, Sector I, 
      Salt Lake City, Kolkata, West Bengal 70064, India skd.humgenet@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180731
PL  - England
TA  - Biosci Rep
JT  - Bioscience reports
JID - 8102797
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Asian People/genetics
MH  - Chronic Periodontitis/epidemiology/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - Humans
MH  - India/epidemiology
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Promoter Regions, Genetic
MH  - Tumor Necrosis Factor-alpha/*genetics
MH  - Young Adult
PMC - PMC6066656
OTO - NOTNLM
OT  - PCR-sequencing
OT  - Periodontitis
OT  - SNP
OT  - TNF-alpha
OT  - allele
OT  - genotype
COIS- The authors declare that there are no competing interests associated with the 
      manuscript.
EDAT- 2018/02/17 06:00
MHDA- 2019/04/16 06:00
PMCR- 2018/07/31
CRDT- 2018/02/17 06:00
PHST- 2017/09/05 00:00 [received]
PHST- 2018/02/13 00:00 [revised]
PHST- 2018/02/15 00:00 [accepted]
PHST- 2018/02/17 06:00 [pubmed]
PHST- 2019/04/16 06:00 [medline]
PHST- 2018/02/17 06:00 [entrez]
PHST- 2018/07/31 00:00 [pmc-release]
AID - BSR20171212 [pii]
AID - 10.1042/BSR20171212 [doi]
PST - epublish
SO  - Biosci Rep. 2018 Jul 31;38(4):BSR20171212. doi: 10.1042/BSR20171212. Print 2018 
      Aug 31.