PMID- 29450164
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220316
IS  - 2214-7632 (Electronic)
IS  - 2214-7632 (Linking)
VI  - 3
DP  - 2014 Jun
TI  - Late gadolinium enhancement (LGE) progresses with right ventricle volume in 
      children after repair of tetralogy of fallot.
PG  - 15-20
LID - 10.1016/j.ijchv.2014.01.002 [doi]
AB  - BACKGROUND: Fibrosis after myocardial damage can be determined by cardiac 
      magnetic resonance (CMR) with late gadolinium enhancement (LGE). We studied 
      whether ventricular LGE is visible in the ventricles of pediatric and adolescent 
      TOF (tetralogy of Fallot) patients by measuring LGE and investigating whether 
      fibrosis correlated with right ventricular volume, pulmonary regurgitation, 
      N-terminal pro-brain natriuretic peptide (NT-proBNP) or the aminoterminal 
      propeptide of type III procollagen (PIIINP). We also studied if the patient's 
      age, post-operative follow-up time or surgical history would affect LGE. METHODS: 
      A total of 40 pediatric patients who had undergone TOF repair and 43 healthy age 
      and gender matched controls underwent a CMR study, whereby LGE was scored in the 
      right (RV) and the left ventricle. To exclude the possible iatrogenic scarring we 
      calculated the LGE score by excluding the right ventricular outflow tract and VSD 
      patch region. RESULTS: All patients had RV LGE and in 39 of 40 it was seen also 
      outside the surgically affected areas. The amount of LGE correlated positively 
      with the RV end-diastolic volume (r = 0.44, P = 0.0045), pulmonary regurgitation 
      (r = 0.40, P = 0.013), and with NT-proBNP. The presence of LGE also depended on 
      post-operative follow-up time (r = 0.53, P = 0.006). PIIINP levels of TOF 
      patients were significantly higher than in the control subjects but it did not 
      correlate with LGE or with any of the studied clinical markers. CONCLUSIONS: LGE 
      is present globally in the right ventricular muscle in children and adolescents 
      with TOF. The longer the follow-up time the more common was the LGE in the right 
      ventricle.
FAU - Ylitalo, Pekka
AU  - Ylitalo P
AD  - Children's Hospital, University of Helsinki and Helsinki University Central 
      Hospital, Helsinki, Finland.
FAU - Pitkanen, Olli M
AU  - Pitkanen OM
AD  - Children's Hospital, University of Helsinki and Helsinki University Central 
      Hospital, Helsinki, Finland.
FAU - Lauerma, Kirsi
AU  - Lauerma K
AD  - Helsinki Medical Imaging Center, Helsinki University Central Hospital, Helsinki, 
      Finland.
FAU - Holmstrom, Miia
AU  - Holmstrom M
AD  - Helsinki Medical Imaging Center, Helsinki University Central Hospital, Helsinki, 
      Finland.
FAU - Rahkonen, Otto
AU  - Rahkonen O
AD  - Children's Hospital, University of Helsinki and Helsinki University Central 
      Hospital, Helsinki, Finland.
FAU - Heikinheimo, Markku
AU  - Heikinheimo M
AD  - Children's Hospital, University of Helsinki and Helsinki University Central 
      Hospital, Helsinki, Finland.
FAU - Sairanen, Heikki
AU  - Sairanen H
AD  - Children's Hospital, University of Helsinki and Helsinki University Central 
      Hospital, Helsinki, Finland.
FAU - Jokinen, Eero
AU  - Jokinen E
AD  - Children's Hospital, University of Helsinki and Helsinki University Central 
      Hospital, Helsinki, Finland.
LA  - eng
PT  - Journal Article
DEP - 20140212
PL  - Ireland
TA  - Int J Cardiol Heart Vessel
JT  - International journal of cardiology. Heart & vessels
JID - 101640846
PMC - PMC5801263
OTO - NOTNLM
OT  - Cardiac magnetic resonance
OT  - Late gadolinium enhancement
OT  - Pediatric cardiology
OT  - Pulmonary regurgitation
OT  - Right ventricular volume
OT  - Tetralogy of Fallot
EDAT- 2014/02/12 00:00
MHDA- 2014/02/12 00:01
PMCR- 2014/02/12
CRDT- 2018/02/17 06:00
PHST- 2013/12/13 00:00 [received]
PHST- 2014/01/31 00:00 [accepted]
PHST- 2018/02/17 06:00 [entrez]
PHST- 2014/02/12 00:00 [pubmed]
PHST- 2014/02/12 00:01 [medline]
PHST- 2014/02/12 00:00 [pmc-release]
AID - S2214-7632(14)00004-2 [pii]
AID - 10.1016/j.ijchv.2014.01.002 [doi]
PST - epublish
SO  - Int J Cardiol Heart Vessel. 2014 Feb 12;3:15-20. doi: 
      10.1016/j.ijchv.2014.01.002. eCollection 2014 Jun.