PMID- 29450725
OWN - NLM
STAT- MEDLINE
DCOM- 20181211
LR  - 20181211
IS  - 1432-0878 (Electronic)
IS  - 0302-766X (Linking)
VI  - 373
IP  - 3
DP  - 2018 Sep
TI  - BDNF effects on dendritic spine morphology and hippocampal function.
PG  - 729-741
LID - 10.1007/s00441-017-2782-x [doi]
AB  - Neurotrophins, including brain-derived neurotrophic factor (BDNF), are expressed 
      in the hippocampus, as well as their precursors, the pro-neurotrophins. The 
      neurotrophins signal through specific tyrosine kinase receptors and the low 
      affinity receptor p75NTR. Moreover, the pro-neurotrophins are considered to be 
      biologically active by signaling through specific receptors. The neurotrophins, 
      especially BDNF, are involved in processes related to learning and memory. 
      Furthermore, it is thought that BDNF also plays a crucial role in major 
      depression. This points to a role of BDNF as a central regulator of neuronal 
      plasticity within the postnatal hippocampus. Morphological correlates of neuronal 
      plasticity are changes on the level of the dendritic spines and, at least in the 
      dentate gyrus of the hippocampus, on the level of adult neurogenesis. Specific 
      changes in dendritic spines as well as in adult hippocampal neurogenesis can be 
      seen in the context of several forms of learning and memory, and it is known that 
      depression is accompanied by declines in the rate of adult neurogenesis and in 
      spine densities. The possible roles of BDNF in neuronal plasticity within the 
      hippocampus are highlighted in this review by focusing on the morphological 
      components of neuronal plasticity.
FAU - von Bohlen Und Halbach, Oliver
AU  - von Bohlen Und Halbach O
AD  - Institut fur Anatomie und Zellbiologie, Universitatsmedizin Greifswald, 
      Friedrich-Loeffler-Str. 23c, 17487, Greifswald, Germany. 
      oliver.vonbohlen@uni-greifswald.de.
FAU - von Bohlen Und Halbach, Viola
AU  - von Bohlen Und Halbach V
AD  - Institut fur Anatomie und Zellbiologie, Universitatsmedizin Greifswald, 
      Friedrich-Loeffler-Str. 23c, 17487, Greifswald, Germany.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180215
PL  - Germany
TA  - Cell Tissue Res
JT  - Cell and tissue research
JID - 0417625
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Dendritic Spines/*metabolism
MH  - Hippocampus/*physiology
MH  - Humans
MH  - Long-Term Potentiation
MH  - Long-Term Synaptic Depression
MH  - Mice
MH  - Mice, Knockout
MH  - Mice, Transgenic
MH  - Neuronal Plasticity/physiology
MH  - Neurons/*metabolism
MH  - Polymorphism, Genetic/genetics
MH  - Rats
MH  - Synapses/physiology
OTO - NOTNLM
OT  - Dendritic spine
OT  - Enriched environment
OT  - Voluntary exercise
OT  - p75NTR
OT  - trkB
EDAT- 2018/02/17 06:00
MHDA- 2018/12/12 06:00
CRDT- 2018/02/17 06:00
PHST- 2017/09/12 00:00 [received]
PHST- 2017/12/22 00:00 [accepted]
PHST- 2018/02/17 06:00 [pubmed]
PHST- 2018/12/12 06:00 [medline]
PHST- 2018/02/17 06:00 [entrez]
AID - 10.1007/s00441-017-2782-x [pii]
AID - 10.1007/s00441-017-2782-x [doi]
PST - ppublish
SO  - Cell Tissue Res. 2018 Sep;373(3):729-741. doi: 10.1007/s00441-017-2782-x. Epub 
      2018 Feb 15.