PMID- 29452774
OWN - NLM
STAT- MEDLINE
DCOM- 20181009
LR  - 20181202
IS  - 1878-3252 (Electronic)
IS  - 0946-672X (Linking)
VI  - 49
DP  - 2018 Sep
TI  - Dietary zinc intake and whole blood zinc concentration in subjects with type 2 
      diabetes versus healthy subjects: A systematic review, meta-analysis and 
      meta-regression.
PG  - 241-251
LID - S0946-672X(18)30008-7 [pii]
LID - 10.1016/j.jtemb.2018.02.008 [doi]
AB  - The aim of this systematic review, meta-analysis and meta-regression was to 
      examine the relationship between type 2 diabetes mellitus (T2DM) and 
      concentration of zinc in whole blood, as well as dietary zinc intake. Searches 
      were performed using Ovid MEDLINE, Embase (Ovid) and The Cochrane Library 
      (CENTRAL). Observational studies conducted on diabetic and healthy adults, with 
      data on dietary zinc intake and/or concentration of zinc in whole blood, were 
      selected. The search strategy yielded 11,150 publications and the manual search 
      6, of which 11 were included in the meta-analyses. Mean difference (MD) and 95% 
      confidence interval (CI), were calculated using the generic inverse-variance 
      method with random-effects models. Heterogeneity was assessed by the Cochran 
      Q-statistic and quantified by the I(2) statistic. Meta-regressions and stratified 
      analysis were used to examine whether any covariate had influence on the results. 
      The pooled MD for the dietary zinc intake meta-analysis was -0.40 (95% CI: -1.59 
      to 0.79; I(2) = 61.0%). Differences between diabetic and non-diabetic subjects 
      became significant in the presence of complications associated with diabetes 
      (MD = -2.26; 95% CI: -3.49 to -1.02; I(2) = 11.9%). Meta-regression showed that 
      for each year since the diagnosis of diabetes the concentration of zinc in whole 
      blood decreased in diabetic patients regarding healthy controls [MD 
      (concentration of zinc in blood) = 732.61 + (-77.88303) x (duration of diabetes 
      in years)], which is not generally explained by a lower intake of zinc.
CI  - Copyright (c) 2018. Published by Elsevier GmbH.
FAU - Fernandez-Cao, Jose C
AU  - Fernandez-Cao JC
AD  - Departamento de Nutricion y Dietetica, Facultad de Ciencias de la Salud (Campus 
      Cordillera), Universidad de Atacama, Avda. Copayapu 2862, III Region, 1570000 
      Copiapo, Chile; Unidad de Nutricion y Salud Publica, Facultad de Medicina y 
      Ciencias de la Salud, Universitat Rovira i Virgili, C/ Sant Llorenc 21, 43201 
      Reus, Spain. Electronic address: jose.fernandez.cao@uda.cl.
FAU - Warthon-Medina, Marisol
AU  - Warthon-Medina M
AD  - Nutritional Epidemiology Group, School of Food Science and Nutrition, University 
      of Leeds, Woodhouse Ln, Leeds LS2 9JT, UK; International Institute of Nutritional 
      Sciences and Food Safety Studies, University of Central Lancashire, Darwin 
      Building, c/o Psychology School Office, Preston, Lancashire PR1 2HE, UK. 
      Electronic address: M.WarthonMedina@leeds.ac.uk.
FAU - Hall Moran, Victoria
AU  - Hall Moran V
AD  - Maternal and Infant Nutrition and Nurture Unit, University of Central Lancashire, 
      Preston PR 1 2HE, UK. Electronic address: VLMoran@uclan.ac.uk.
FAU - Arija, Victoria
AU  - Arija V
AD  - Unidad de Nutricion y Salud Publica, Facultad de Medicina y Ciencias de la Salud, 
      Universitat Rovira i Virgili, C/ Sant Llorenc 21, 43201 Reus, Spain. Electronic 
      address: victoria.arija@urv.cat.
FAU - Doepking, Carlos
AU  - Doepking C
AD  - Departamento de Nutricion y Dietetica, Facultad de Ciencias de la Salud (Campus 
      Cordillera), Universidad de Atacama, Avda. Copayapu 2862, III Region, 1570000 
      Copiapo, Chile. Electronic address: carlos.doepking@uda.cl.
FAU - Lowe, Nicola M
AU  - Lowe NM
AD  - International Institute of Nutritional Sciences and Food Safety Studies, 
      University of Central Lancashire, Darwin Building, c/o Psychology School Office, 
      Preston, Lancashire PR1 2HE, UK. Electronic address: NMLowe@uclan.ac.uk.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20180207
PL  - Germany
TA  - J Trace Elem Med Biol
JT  - Journal of trace elements in medicine and biology : organ of the Society for 
      Minerals and Trace Elements (GMS)
JID - 9508274
RN  - J41CSQ7QDS (Zinc)
SB  - IM
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Dietary Supplements
MH  - Humans
MH  - Zinc/administration & dosage/*blood
OTO - NOTNLM
OT  - EURRECA
OT  - Review
OT  - Type 2 diabetes mellitus
OT  - Zinc
EDAT- 2018/02/18 06:00
MHDA- 2018/10/10 06:00
CRDT- 2018/02/18 06:00
PHST- 2018/01/03 00:00 [received]
PHST- 2018/02/02 00:00 [revised]
PHST- 2018/02/05 00:00 [accepted]
PHST- 2018/02/18 06:00 [pubmed]
PHST- 2018/10/10 06:00 [medline]
PHST- 2018/02/18 06:00 [entrez]
AID - S0946-672X(18)30008-7 [pii]
AID - 10.1016/j.jtemb.2018.02.008 [doi]
PST - ppublish
SO  - J Trace Elem Med Biol. 2018 Sep;49:241-251. doi: 10.1016/j.jtemb.2018.02.008. 
      Epub 2018 Feb 7.