PMID- 29452785
OWN - NLM
STAT- MEDLINE
DCOM- 20180613
LR  - 20181202
IS  - 1873-4111 (Electronic)
IS  - 0378-5122 (Linking)
VI  - 109
DP  - 2018 Mar
TI  - The risks of sarcopenia, falls and fractures in patients with type 2 diabetes 
      mellitus.
PG  - 70-77
LID - S0378-5122(17)30945-3 [pii]
LID - 10.1016/j.maturitas.2017.12.011 [doi]
AB  - Fracture risk in patients with type 2 diabetes mellitus (T2DM) is increased, and 
      the mechanism is multifactorial. Recent research on T2DM-induced bone fragility 
      shows that bone mineral density (BMD) is often normal or even slightly elevated. 
      However, bone turnover may be decreased and bone material and microstructural 
      properties are altered, especially when microvascular complications are present. 
      Besides bone fragility, extra-skeletal factors leading to an increased propensity 
      to experience falls may also contribute to the increased fracture risk in T2DM, 
      such as peripheral neuropathy, retinopathy and diabetes medication (e.g. insulin 
      use). One of the probable additional contributing factors to the increased fall 
      and fracture risks in T2DM is sarcopenia, the age-related decline in skeletal 
      muscle mass, quality and function. Although the association between sarcopenia, 
      fall risk, and fracture risk has been studied in the general population, few 
      studies have examined the association between T2DM and muscle tissue and the 
      risks of falls and fractures. This narrative review provides an overview of the 
      literature regarding the multifactorial mechanisms leading to increased fracture 
      risk in patients with T2DM, with a focus on sarcopenia and falls.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Sarodnik, C
AU  - Sarodnik C
AD  - NUTRIM Research School, Maastricht University, Maastricht, The Netherlands.
FAU - Bours, S P G
AU  - Bours SPG
AD  - Department of Internal Medicine, Subdivision Rheumatology, Maastricht University 
      Medical Centre, Maastricht, The Netherlands; CAPHRI Research School, Maastricht 
      University, Maastricht, The Netherlands.
FAU - Schaper, N C
AU  - Schaper NC
AD  - NUTRIM Research School, Maastricht University, Maastricht, The Netherlands; 
      Department of Internal Medicine, Subdivision Endocrinology, Maastricht University 
      Medical Centre, Maastricht, The Netherlands.
FAU - van den Bergh, J P
AU  - van den Bergh JP
AD  - NUTRIM Research School, Maastricht University, Maastricht, The Netherlands; 
      Department of Internal Medicine, Subdivision Rheumatology, Maastricht University 
      Medical Centre, Maastricht, The Netherlands; Department of Internal Medicine, 
      VieCuri Medical Center, Venlo, The Netherlands; University Hasselt, Biomedical 
      Research Institute, Hasselt, Belgium.
FAU - van Geel, T A C M
AU  - van Geel TACM
AD  - Maastricht University, CAPHRI Research School, Department of Family Medicine, 
      Maastricht University, Maastricht, The Netherlands. Electronic address: 
      tineke.vangeel@maastrichtuniversity.nl.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20171215
PL  - Ireland
TA  - Maturitas
JT  - Maturitas
JID - 7807333
SB  - IM
MH  - Accidental Falls/*statistics & numerical data
MH  - Bone Density
MH  - Diabetes Mellitus, Type 2/*epidemiology
MH  - Fractures, Bone/*epidemiology
MH  - Humans
MH  - Risk Factors
MH  - Sarcopenia/*epidemiology
OTO - NOTNLM
OT  - Bone quality
OT  - Falls
OT  - Fracture risk
OT  - Sarcopenia
OT  - Type 2 diabetes mellitus
EDAT- 2018/02/18 06:00
MHDA- 2018/06/14 06:00
CRDT- 2018/02/18 06:00
PHST- 2017/09/29 00:00 [received]
PHST- 2017/12/08 00:00 [revised]
PHST- 2017/12/12 00:00 [accepted]
PHST- 2018/02/18 06:00 [entrez]
PHST- 2018/02/18 06:00 [pubmed]
PHST- 2018/06/14 06:00 [medline]
AID - S0378-5122(17)30945-3 [pii]
AID - 10.1016/j.maturitas.2017.12.011 [doi]
PST - ppublish
SO  - Maturitas. 2018 Mar;109:70-77. doi: 10.1016/j.maturitas.2017.12.011. Epub 2017 
      Dec 15.