PMID- 29453967
OWN - NLM
STAT- MEDLINE
DCOM- 20191014
LR  - 20191210
IS  - 1096-0805 (Electronic)
IS  - 0022-2011 (Linking)
VI  - 154
DP  - 2018 May
TI  - Discovery of anti-viral molecules and their vital functions in Bombyx mori.
PG  - 12-18
LID - S0022-2011(17)30537-2 [pii]
LID - 10.1016/j.jip.2018.02.012 [doi]
AB  - The silkworm Bombyx mori (B. mori), a lepidopteran model organism, has become an 
      important model for molecular biology researches with its genome completely 
      sequenced. Silkworms confront different types of virus diseases, mainly including 
      those caused by Bombyx mori nucleopolyhedrovirus (BmNPV), Bombyx mori densovirus 
      type 1 (BmDNV-1), Bombyx mori bidesovirus (BmBDV) which was termed as Bombyx mori 
      densovirus type 2 (BmDNV-2) or Bombyx mori parvo-like virus (BmPLV) before in 
      sericulture. B. mori offers excellent models to study the molecular mechanisms of 
      insect innate immune responses to viruses. A variety of molecules and pathways 
      have been identified to be involved in the immune responses in the silkworm to 
      viruses, such as the antimicrobial peptides, prophenoloxidase-activating system, 
      apoptosis, ROS, small RNA and related molecules. Here in this review, we 
      summarize the current research advances in molecules involved in silkworm 
      anti-virus pathways. Moreover, taking BmNPV as an example, we proposed a 
      schematic model of molecules and pathways involved in silkworm immune responses 
      against virus infection. We hope this review can facilitate further study of 
      antiviral mechanisms in silkworm, and provide a reference for virus diseases in 
      other organisms.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Lu, Peng
AU  - Lu P
AD  - Institute of Life Sciences, Jiangsu University, Zhenjiang 212013, China. 
      Electronic address: penglu@ujs.edu.cn.
FAU - Pan, Ye
AU  - Pan Y
AD  - Institute of Life Sciences, Jiangsu University, Zhenjiang 212013, China; School 
      of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China. 
      Electronic address: panye@ujs.edu.cn.
FAU - Yang, Yanhua
AU  - Yang Y
AD  - Institute of Life Sciences, Jiangsu University, Zhenjiang 212013, China. 
      Electronic address: yanhuayang@126.com.
FAU - Zhu, Feifei
AU  - Zhu F
AD  - Institute of Life Sciences, Jiangsu University, Zhenjiang 212013, China. 
      Electronic address: zhufeifei0921@163.com.
FAU - Li, Chengjun
AU  - Li C
AD  - Institute of Life Sciences, Jiangsu University, Zhenjiang 212013, China. 
      Electronic address: lcj3314@163.com.
FAU - Guo, Zhongjian
AU  - Guo Z
AD  - Institute of Life Sciences, Jiangsu University, Zhenjiang 212013, China. 
      Electronic address: gzh762677@ujs.edu.cn.
FAU - Yao, Qin
AU  - Yao Q
AD  - Institute of Life Sciences, Jiangsu University, Zhenjiang 212013, China. 
      Electronic address: yaoqin@ujs.edu.cn.
FAU - Chen, Keping
AU  - Chen K
AD  - Institute of Life Sciences, Jiangsu University, Zhenjiang 212013, China. 
      Electronic address: kpchen@ujs.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20180214
PL  - United States
TA  - J Invertebr Pathol
JT  - Journal of invertebrate pathology
JID - 0014067
RN  - 0 (Heat-Shock Proteins)
RN  - 0 (Insect Proteins)
RN  - 0 (Reactive Oxygen Species)
SB  - IM
MH  - Animals
MH  - Autophagy
MH  - Bombyx/*immunology/virology
MH  - Heat-Shock Proteins/physiology
MH  - Immunity, Innate
MH  - Insect Proteins/physiology
MH  - Models, Immunological
MH  - Nucleopolyhedroviruses/*immunology
MH  - RNA Interference
MH  - Reactive Oxygen Species
OTO - NOTNLM
OT  - Autophagy
OT  - BmBDV
OT  - BmCPV
OT  - BmDNV
OT  - BmNPV
OT  - Bombyx mori
OT  - Immune response
OT  - Molecular mechanism
EDAT- 2018/02/18 06:00
MHDA- 2019/10/15 06:00
CRDT- 2018/02/18 06:00
PHST- 2016/08/10 00:00 [received]
PHST- 2018/01/03 00:00 [revised]
PHST- 2018/02/13 00:00 [accepted]
PHST- 2018/02/18 06:00 [pubmed]
PHST- 2019/10/15 06:00 [medline]
PHST- 2018/02/18 06:00 [entrez]
AID - S0022-2011(17)30537-2 [pii]
AID - 10.1016/j.jip.2018.02.012 [doi]
PST - ppublish
SO  - J Invertebr Pathol. 2018 May;154:12-18. doi: 10.1016/j.jip.2018.02.012. Epub 2018 
      Feb 14.