PMID- 29454058
OWN - NLM
STAT- MEDLINE
DCOM- 20180920
LR  - 20180920
IS  - 1879-0003 (Electronic)
IS  - 0141-8130 (Linking)
VI  - 112
DP  - 2018 Jun
TI  - Carboxymethyl konjac glucomannan - crosslinked chitosan sponges for wound 
      dressing.
PG  - 1225-1233
LID - S0141-8130(17)34995-4 [pii]
LID - 10.1016/j.ijbiomac.2018.02.075 [doi]
AB  - In this paper, carboxymethyl konjac glucomannan (CMKGM) was obtained by carboxyl 
      modification of konjac glucomannan. Then CMKGM and chitosan (CS) were crosslinked 
      and freeze-dried to prepare CMKGM/CS composite sponges with different 
      proportions. The structure and micromorphology of CMKGM/CS sponges were 
      investigated by FTIR spectroscopy and SEM. The SEM results showed that the pore 
      structure of the composite sponge gradually increased with the increase of CMKGM 
      content. To assess the applicability of CMKGM/CS composite sponges as wound 
      dressing, the swelling behavior, water vapor transmission rate (WVTR), 
      biocompatibility (cytotoxicity and hemolysis) were analyzed. The results 
      indicated that CMKGM/CS composite sponges possessed high swelling ratio, proper 
      WVTR and good biocompatibility, which might accelerate tissue regeneration. 
      Meanwhile, in vivo experiments demonstrated that CMKGM/CS composite sponges could 
      effectively heal full-layer wound of skin defects of male ICR mice.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Xie, Yu
AU  - Xie Y
AD  - College of Chemistry and Bio-Engineering, Yichun University, Yichun 336000, 
      China; Joint Research Center of Qingdao Institute of Bioenergy and Bioprocess 
      Technology of Chinese Academy of Sciences and Yichun University, Yichun 336000, 
      China.
FAU - Yi, Zeng-Xing
AU  - Yi ZX
AD  - College of Chemistry and Bio-Engineering, Yichun University, Yichun 336000, 
      China; Joint Research Center of Qingdao Institute of Bioenergy and Bioprocess 
      Technology of Chinese Academy of Sciences and Yichun University, Yichun 336000, 
      China.
FAU - Wang, Jian-Xun
AU  - Wang JX
AD  - CAS Key Laboratory of Bio-based Materials, Qingdao Institute of Bioenergy and 
      Bioprocess Technology, Chinese Academy of Sciences, Qingdao, 266101, China; Joint 
      Research Center of Qingdao Institute of Bioenergy and Bioprocess Technology of 
      Chinese Academy of Sciences and Yichun University, Yichun 336000, China.
FAU - Hou, Tong-Gang
AU  - Hou TG
AD  - CAS Key Laboratory of Bio-based Materials, Qingdao Institute of Bioenergy and 
      Bioprocess Technology, Chinese Academy of Sciences, Qingdao, 266101, China; Joint 
      Research Center of Qingdao Institute of Bioenergy and Bioprocess Technology of 
      Chinese Academy of Sciences and Yichun University, Yichun 336000, China.
FAU - Jiang, Qiong
AU  - Jiang Q
AD  - College of Chemistry and Bio-Engineering, Yichun University, Yichun 336000, 
      China; Joint Research Center of Qingdao Institute of Bioenergy and Bioprocess 
      Technology of Chinese Academy of Sciences and Yichun University, Yichun 336000, 
      China. Electronic address: 502011@jxycu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20180214
PL  - Netherlands
TA  - Int J Biol Macromol
JT  - International journal of biological macromolecules
JID - 7909578
RN  - 0 (Cross-Linking Reagents)
RN  - 0 (Mannans)
RN  - 0 (Steam)
RN  - 0 (carboxymethyl konjac glucomannan)
RN  - 9012-76-4 (Chitosan)
SB  - IM
MH  - Animals
MH  - *Bandages
MH  - Cell Death/drug effects
MH  - Cell Survival/drug effects
MH  - Cells, Cultured
MH  - Chitosan/*chemistry/pharmacology
MH  - Cross-Linking Reagents/*chemistry
MH  - Fibroblasts/cytology/drug effects
MH  - Hemolysis/drug effects
MH  - Humans
MH  - Male
MH  - Mannans/chemical synthesis/*chemistry/pharmacology
MH  - Mice, Inbred ICR
MH  - Porosity
MH  - Rabbits
MH  - Spectroscopy, Fourier Transform Infrared
MH  - Steam/analysis
MH  - Temperature
MH  - Thermogravimetry
MH  - *Wound Healing
MH  - X-Ray Diffraction
OTO - NOTNLM
OT  - CMKGM
OT  - Sponge
OT  - Wound dressing
EDAT- 2018/02/18 06:00
MHDA- 2018/09/21 06:00
CRDT- 2018/02/18 06:00
PHST- 2017/12/14 00:00 [received]
PHST- 2018/01/31 00:00 [revised]
PHST- 2018/02/11 00:00 [accepted]
PHST- 2018/02/18 06:00 [pubmed]
PHST- 2018/09/21 06:00 [medline]
PHST- 2018/02/18 06:00 [entrez]
AID - S0141-8130(17)34995-4 [pii]
AID - 10.1016/j.ijbiomac.2018.02.075 [doi]
PST - ppublish
SO  - Int J Biol Macromol. 2018 Jun;112:1225-1233. doi: 10.1016/j.ijbiomac.2018.02.075. 
      Epub 2018 Feb 14.