PMID- 29454268 OWN - NLM STAT- MEDLINE DCOM- 20180608 LR - 20180608 IS - 1090-2414 (Electronic) IS - 0147-6513 (Linking) VI - 154 DP - 2018 Jun 15 TI - Occurrence and distribution of antibiotics in mariculture farms, estuaries and the coast of the Beibu Gulf, China: Bioconcentration and diet safety of seafood. PG - 27-35 LID - S0147-6513(18)30074-5 [pii] LID - 10.1016/j.ecoenv.2018.02.006 [doi] AB - The occurrence, distribution, bioconcentration and diet safety via seafood consumption of 19 antibiotics were investigated in eight closed mariculture ponds, four estuaries, two nearshore areas and one offshore area from the Beibu Gulf. Seventeen, 16, 15 and 7 antibiotics were detected at total concentrations of 43.2 - 885 ng L(-1), 22.4 - 118 ng L(-1), 22.7 - 24.5 ng L(-1), and 1.81-3.23 ng L(-1) in the water of the above different areas, respectively. This indicates that the mariculture ponds are important sources of antibiotic pollution on the coast of the Beibu Gulf. Ten antibiotics were detected in feed samples with concentrations ranging from 0.03 to 95.4 ng g(-1), demonstrating the presence of antibiotics in the feed and/or residual antibiotics in the raw material of the feed. The field bioconcentration factors (BCFs) of the antibiotics calculated in different culture organisms ranged from 0.55 to 10,774 L kg(-1). The estimated daily intakes (EDIs) of sulphonamides, fluoroquinolones, macrolides and chloramphenicols via aquatic products were 19.8-105, 33.7-178, 34.9-186 and 6.9-37.1 ng d(-1), respectively. According to the acceptable daily intakes (ADIs) and maximum residue limits (MRLs) proposed by different organisations, these aquatic products (shrimp, crab and oyster) reached the standard of safe consumption and could not pose a health risk to humans. However, a potential elevated risk to humans may remain because of the occurrence of multiple antibiotics in the cultured organisms, particularly for sensitive populations, such as pregnant women, the elderly and children. CI - Copyright (c) 2018 Elsevier Inc. All rights reserved. FAU - Zhang, Ruiling AU - Zhang R AD - School of Marine Sciences, Guangxi University, Nanning 530004, China; Guangxi Laboratory on the Study of Coral Reefs in the South China Sea, Coral Reef Research Center of China, Guangxi University, Nanning 530004, China; School of Resources, Environment and Materials, Guangxi University, Nanning 530004, China. FAU - Pei, Jiying AU - Pei J AD - School of Marine Sciences, Guangxi University, Nanning 530004, China; Guangxi Laboratory on the Study of Coral Reefs in the South China Sea, Coral Reef Research Center of China, Guangxi University, Nanning 530004, China. FAU - Zhang, Ruijie AU - Zhang R AD - School of Marine Sciences, Guangxi University, Nanning 530004, China; Guangxi Laboratory on the Study of Coral Reefs in the South China Sea, Coral Reef Research Center of China, Guangxi University, Nanning 530004, China. Electronic address: rjzhang@gxu.edu.cn. FAU - Wang, Shaopeng AU - Wang S AD - School of Marine Sciences, Guangxi University, Nanning 530004, China; Guangxi Laboratory on the Study of Coral Reefs in the South China Sea, Coral Reef Research Center of China, Guangxi University, Nanning 530004, China. FAU - Zeng, Weibin AU - Zeng W AD - School of Marine Sciences, Guangxi University, Nanning 530004, China; Guangxi Laboratory on the Study of Coral Reefs in the South China Sea, Coral Reef Research Center of China, Guangxi University, Nanning 530004, China; School of Resources, Environment and Materials, Guangxi University, Nanning 530004, China. FAU - Huang, Dali AU - Huang D AD - School of Marine Sciences, Guangxi University, Nanning 530004, China; Guangxi Laboratory on the Study of Coral Reefs in the South China Sea, Coral Reef Research Center of China, Guangxi University, Nanning 530004, China; School of Resources, Environment and Materials, Guangxi University, Nanning 530004, China. FAU - Wang, Yi AU - Wang Y AD - School of Marine Sciences, Guangxi University, Nanning 530004, China; Guangxi Laboratory on the Study of Coral Reefs in the South China Sea, Coral Reef Research Center of China, Guangxi University, Nanning 530004, China; School of Resources, Environment and Materials, Guangxi University, Nanning 530004, China. FAU - Zhang, Yuanyuan AU - Zhang Y AD - School of Marine Sciences, Guangxi University, Nanning 530004, China; Guangxi Laboratory on the Study of Coral Reefs in the South China Sea, Coral Reef Research Center of China, Guangxi University, Nanning 530004, China. FAU - Wang, Yinghui AU - Wang Y AD - School of Marine Sciences, Guangxi University, Nanning 530004, China; Guangxi Laboratory on the Study of Coral Reefs in the South China Sea, Coral Reef Research Center of China, Guangxi University, Nanning 530004, China. FAU - Yu, Kefu AU - Yu K AD - School of Marine Sciences, Guangxi University, Nanning 530004, China; Guangxi Laboratory on the Study of Coral Reefs in the South China Sea, Coral Reef Research Center of China, Guangxi University, Nanning 530004, China. LA - eng PT - Journal Article DEP - 20180222 PL - Netherlands TA - Ecotoxicol Environ Saf JT - Ecotoxicology and environmental safety JID - 7805381 RN - 0 (Anti-Bacterial Agents) RN - 0 (Water Pollutants, Chemical) SB - IM MH - Anti-Bacterial Agents/*analysis MH - *Aquaculture MH - Child MH - China MH - Dietary Exposure/analysis MH - Environmental Monitoring/*methods MH - *Estuaries MH - Food Contamination/*analysis MH - Food Safety MH - Humans MH - Seafood/*analysis/standards MH - Water Pollutants, Chemical/*analysis OTO - NOTNLM OT - Antibiotics OT - Beibu Gulf OT - Bioconcentration OT - Diet safety OT - Mariculture EDAT- 2018/02/18 06:00 MHDA- 2018/06/09 06:00 CRDT- 2018/02/18 06:00 PHST- 2017/11/20 00:00 [received] PHST- 2018/01/28 00:00 [revised] PHST- 2018/02/02 00:00 [accepted] PHST- 2018/02/18 06:00 [pubmed] PHST- 2018/06/09 06:00 [medline] PHST- 2018/02/18 06:00 [entrez] AID - S0147-6513(18)30074-5 [pii] AID - 10.1016/j.ecoenv.2018.02.006 [doi] PST - ppublish SO - Ecotoxicol Environ Saf. 2018 Jun 15;154:27-35. doi: 10.1016/j.ecoenv.2018.02.006. Epub 2018 Feb 22.