PMID- 29454288
OWN - NLM
STAT- MEDLINE
DCOM- 20180831
LR  - 20180831
IS  - 1950-6007 (Electronic)
IS  - 0753-3322 (Linking)
VI  - 100
DP  - 2018 Apr
TI  - Apocynum venetum leaf extract reverses depressive-like behaviors in chronically 
      stressed rats by inhibiting oxidative stress and apoptosis.
PG  - 394-406
LID - S0753-3322(17)35846-8 [pii]
LID - 10.1016/j.biopha.2018.01.137 [doi]
AB  - BACKGROUND: Major depressive disorder (MDD) is a common but serious psychiatric 
      disorder, but current treatments are inadequate for approximately half of the 
      patients with MDD. Thus, better methods of treatment are urgently needed. This 
      study aimed to investigate the antidepressant-like effects and potential 
      mechanism of Apocynum venetum leaf extract (AVLE) in chronic unpredictable mild 
      stress (CUMS) rat model of depression. MATERIALS AND METHODS: The CUMS rat model 
      of depression was used to investigate the antidepressant-like activity and 
      relevant mechanism of AVLE (30, 60, and 125 mg/kg, i.g.). Behavioral tests, 
      including sucrose preference test (SPT), open field test (OFT), and forced 
      swimming test (FST) were conducted to assess anhedonic, despairing, and 
      spontaneous behaviors, respectively. The activity of the 
      hypothalamic-pituitary-adrenal (HPA) axis was evaluated by measuring the serum 
      adrenocorticotrophic hormone (ACTH) and corticosterone (CORT) concentrations. The 
      underlying mechanism was further explored by assessing oxidative stress 
      parameters, cell apoptosis, and brain-derived neurotrophic factor (BDNF) 
      expression in the rat hippocampus exposed to CUMS. RESULTS: The AVLE (36, 60, 
      125 mg/kg) treatment exerted antidepressant-like effects in CUMS-exposed rats 
      similar to fluoxetine (10 mg/kg). The AVLE treatment reduced the serum CORT and 
      ACTH levels in CUMS rats. It also increased the activities and gene expression of 
      antioxidant enzymes (SOD, CAT, and GPx) and decreased the ROS generation levels 
      and the lipid peroxidation marker MDA in the rat hippocampus subjected to CUMS. 
      Additionally, it suppressed the apoptosis of hippocampus cells by modulating 
      Bcl-2/Bax pathways and improved the hippocampal BDNF expressions of CUMS rats. 
      CONCLUSION: Our findings suggested that AVLE exerted antidepressant-like effects 
      in CUMS rats, which was possibly mediated by the prevention of oxidative stress, 
      the inhibition of hippocampal neuronal apoptosis, and the upregulation of the 
      hippocampal BDNF level.
CI  - Copyright (c) 2018 Elsevier Masson SAS. All rights reserved.
FAU - Li, Xiangting
AU  - Li X
AD  - Department of Integrative Medicine, Zhongshan Hospital, Fudan University, China; 
      Institute of Neurology, Academy of Integrative Medicine, Fudan University, 
      Shanghai 200032, China.
FAU - Wu, Ting
AU  - Wu T
AD  - Department of Integrative Medicine, Zhongshan Hospital, Fudan University, China; 
      Institute of Neurology, Academy of Integrative Medicine, Fudan University, 
      Shanghai 200032, China.
FAU - Yu, Zhonghai
AU  - Yu Z
AD  - Department of Integrative Medicine, Zhongshan Hospital, Fudan University, China; 
      Institute of Neurology, Academy of Integrative Medicine, Fudan University, 
      Shanghai 200032, China.
FAU - Li, Tingting
AU  - Li T
AD  - Department of Neurology, Shuguang Hospital, Shanghai University Traditional 
      Chinese Medicine, Shanghai 201203, China.
FAU - Zhang, Jingsi
AU  - Zhang J
AD  - Department of Integrative Medicine, Zhongshan Hospital, Fudan University, China; 
      Institute of Neurology, Academy of Integrative Medicine, Fudan University, 
      Shanghai 200032, China.
FAU - Zhang, Zhennian
AU  - Zhang Z
AD  - Department of Integrative Medicine, Zhongshan Hospital, Fudan University, China; 
      Institute of Neurology, Academy of Integrative Medicine, Fudan University, 
      Shanghai 200032, China.
FAU - Cai, Min
AU  - Cai M
AD  - Department of Integrative Medicine, Zhongshan Hospital, Fudan University, China; 
      Institute of Neurology, Academy of Integrative Medicine, Fudan University, 
      Shanghai 200032, China.
FAU - Zhang, Wen
AU  - Zhang W
AD  - Department of Integrative Medicine, Zhongshan Hospital, Fudan University, China; 
      Institute of Neurology, Academy of Integrative Medicine, Fudan University, 
      Shanghai 200032, China.
FAU - Xiang, Jun
AU  - Xiang J
AD  - Department of Integrative Medicine, Zhongshan Hospital, Fudan University, China; 
      Institute of Neurology, Academy of Integrative Medicine, Fudan University, 
      Shanghai 200032, China. Electronic address: xiang.jun@mail.zs-hospital.sh.cn.
FAU - Cai, Dingfang
AU  - Cai D
AD  - Department of Integrative Medicine, Zhongshan Hospital, Fudan University, China; 
      Institute of Neurology, Academy of Integrative Medicine, Fudan University, 
      Shanghai 200032, China. Electronic address: dingfangcai@163.com.
LA  - eng
PT  - Journal Article
DEP - 20180216
PL  - France
TA  - Biomed Pharmacother
JT  - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
JID - 8213295
RN  - 0 (Antidepressive Agents)
RN  - 0 (Plant Extracts)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/isolation & purification/pharmacology/therapeutic use
MH  - *Apocynum
MH  - Apoptosis/*drug effects/physiology
MH  - Chronic Disease
MH  - Depression/drug therapy/*metabolism
MH  - Dose-Response Relationship, Drug
MH  - Male
MH  - Oxidative Stress/*drug effects/physiology
MH  - Plant Extracts/isolation & purification/*pharmacology/therapeutic use
MH  - Plant Leaves
MH  - Rats
MH  - Rats, Wistar
MH  - Stress, Psychological/drug therapy/*metabolism
OTO - NOTNLM
OT  - Apocynum venetum leaf extract
OT  - Apoptosis
OT  - Chronic unpredictable mild stress
OT  - Cytochrome c (CID: 439171)
OT  - Fluoxetine hydrochloride (CID: 62857)
OT  - Hydrogen peroxide (CID: 784)
OT  - Hyperoside (CID: 5281643)
OT  - Isoquercitrin (CID: 5280804)
OT  - Major depressive disorder
OT  - Malondialdehyde (CID: 10964)
OT  - Oxidative stress
OT  - Quercetin (CID: 5280343)
OT  - Superoxide anion radical (CID: 5359597)
OT  - Superoxide dismutase (CID: 72941490)
EDAT- 2018/02/18 06:00
MHDA- 2018/09/01 06:00
CRDT- 2018/02/18 06:00
PHST- 2017/11/05 00:00 [received]
PHST- 2018/01/07 00:00 [revised]
PHST- 2018/01/28 00:00 [accepted]
PHST- 2018/02/18 06:00 [pubmed]
PHST- 2018/09/01 06:00 [medline]
PHST- 2018/02/18 06:00 [entrez]
AID - S0753-3322(17)35846-8 [pii]
AID - 10.1016/j.biopha.2018.01.137 [doi]
PST - ppublish
SO  - Biomed Pharmacother. 2018 Apr;100:394-406. doi: 10.1016/j.biopha.2018.01.137. 
      Epub 2018 Feb 16.