PMID- 29454289 OWN - NLM STAT- MEDLINE DCOM- 20181011 LR - 20181011 IS - 1879-2219 (Electronic) IS - 0966-6362 (Linking) VI - 61 DP - 2018 Mar TI - Walking speed measurement with an Ambient Measurement System (AMS) in patients with multiple sclerosis and walking impairment. PG - 393-397 LID - S0966-6362(18)30044-4 [pii] LID - 10.1016/j.gaitpost.2018.01.033 [doi] AB - BACKGROUND: Walking speed is an important measure of gait impairment in multiple sclerosis (MS). The clinical assessment of walking speed requires dedicated time, space, and personnel, and may not accurately gauge real-world performance. The term "Ambient Measurement System" (AMS) refers to a new class of device that passively measures walking speed at home, without the need for dedicated space or specialized setup. This study compared an AMS, Echo5D, versus in-clinic standard measures of walking speed on a straight path. METHODS: Twenty participants with MS and walking impairment were recruited from the Cleveland Clinic Mellen Center for MS. Each participant traversed an electronic GAITRite CIRFace (GC) sensor mat four times (two at comfortable pace, two at fast pace). Each participant then performed the Timed 25-Foot Walk (T25FW) twice, measured by a manual stopwatch (SW). All traversals were simultaneously measured by an array of Echo5D devices. Echo5D speeds were correlated with the Patient-Determined Disease Steps and the MS Walking Scale-12 patient-reported outcomes. RESULTS: Pearson correlations between Echo5D and clinical tests ranged from 0.89 to 0.98 (p < 0.0001). No statistically significant bias was found between Echo5D and GC. A small statistically significant bias was found between Echo5D and SW, with Echo5D reporting approximately 5% faster walking speeds in aggregate. CONCLUSIONS: Among MS patients with walking impairments, the Echo5D AMS acquired walking speeds which were closely correlated with the standard measures of GC and SW. The strong agreement supports the use of Echo5D to assess in-home, real-world walking performance in MS. CI - Copyright (c) 2018 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Bethoux, Francois AU - Bethoux F AD - Mellen Center for MS Treatment and Research, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA. Electronic address: bethouf@ccf.org. FAU - Varsanik, Jonathan S AU - Varsanik JS AD - Atlas5D, Inc. One Broadway, Cambridge, MA 02142, USA. Electronic address: jon@atlas5d.com. FAU - Chevalier, Timothy W AU - Chevalier TW AD - Atlas5D, Inc. One Broadway, Cambridge, MA 02142, USA. Electronic address: tim@atlas5d.com. FAU - Halpern, Elkan F AU - Halpern EF AD - Institute for Technology Assessment, 101 Merrimac St., Boston, MA 02114, USA. Electronic address: elk@mgh-ita.org. FAU - Stough, Darlene AU - Stough D AD - Mellen Center for MS Treatment and Research, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA. Electronic address: stoughd@ccf.org. FAU - Kimmel, Zebadiah M AU - Kimmel ZM AD - Atlas5D, Inc. One Broadway, Cambridge, MA 02142, USA. Electronic address: zeb@atlas5d.com. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20180208 PL - England TA - Gait Posture JT - Gait & posture JID - 9416830 SB - IM MH - Adult MH - Disabled Persons/*rehabilitation MH - Female MH - Gait/*physiology MH - Humans MH - Male MH - Middle Aged MH - Multiple Sclerosis/*diagnosis/physiopathology/rehabilitation MH - Walking/*physiology MH - Walking Speed/*physiology OTO - NOTNLM OT - Ambient Measurement System OT - Multiple sclerosis OT - Validation OT - Walking speed EDAT- 2018/02/18 06:00 MHDA- 2018/10/12 06:00 CRDT- 2018/02/18 06:00 PHST- 2017/08/14 00:00 [received] PHST- 2017/12/30 00:00 [revised] PHST- 2018/01/28 00:00 [accepted] PHST- 2018/02/18 06:00 [pubmed] PHST- 2018/10/12 06:00 [medline] PHST- 2018/02/18 06:00 [entrez] AID - S0966-6362(18)30044-4 [pii] AID - 10.1016/j.gaitpost.2018.01.033 [doi] PST - ppublish SO - Gait Posture. 2018 Mar;61:393-397. doi: 10.1016/j.gaitpost.2018.01.033. Epub 2018 Feb 8.