PMID- 29454761
OWN - NLM
STAT- MEDLINE
DCOM- 20191120
LR  - 20210109
IS  - 1876-7591 (Electronic)
IS  - 1876-7591 (Linking)
VI  - 11
IP  - 11
DP  - 2018 Nov
TI  - Diagnostic Accuracy of Cardiovascular Magnetic Resonance in Acute Myocarditis: A 
      Systematic Review and Meta-Analysis.
PG  - 1583-1590
LID - S1936-878X(17)31182-8 [pii]
LID - 10.1016/j.jcmg.2017.12.008 [doi]
AB  - OBJECTIVES: The purpose of this systematic review was to explore the diagnostic 
      accuracy of various cardiovascular magnetic resonance (CMR) index tests for the 
      diagnosis of acute myocarditis in adult patients. BACKGROUND: Acute myocarditis 
      remains one of the most challenging diagnoses in cardiology. CMR has emerged as 
      the diagnostic tool of choice to detect acute myocardial injury and necrosis in 
      patients with suspected myocarditis. METHODS: We considered all diagnostic cohort 
      and case-control studies. We searched MEDLINE, EMBASE, Cochrane Library, SCOPUS, 
      and Web of Science up to April 21, 2017. We used the Quality Assessment of 
      Diagnostic Accuracy Studies-2 tool to assess the quality of included studies. 
      PROSPERO registration number CRD42017055778 was used. RESULTS: Twenty-two studies 
      were included in the systematic review. Because significant heterogeneity exists 
      among the studies, we only present hierarchical receiver operator curves. The 
      areas under the curve (AUC) for each index test were for T1 mapping 0.95 (95% 
      confidence interval [CI]: 0.93 to 0.97), for T2 mapping 0.88 (95% CI: 0.85 to 
      0.91), for extracellular volume fraction (ECV) 0.81 (95% CI: 0.78 to 0.85), for 
      increased T2 ratio/signal 0.80 (95% CI: 0.76 to 0.83), for late gadolinium 
      enhancement (LGE) 0.87 (95% CI: 0.84 to 0.90), for early gadolinium enhancement 
      (EGE) 0.78 (95% CI: 0.74 to 0.81), and for the Lake Louise criteria (LLC) 0.81 
      (95% CI: 0.77 to 0.84). Native T1 mapping had superior diagnostic accuracy across 
      all index tests. The AUC of T2 mapping was greater than the AUC of increased T2 
      ratio/signal and EGE, whereas ECV showed no superiority compared with other index 
      tests. LGE had better diagnostic accuracy compared with the classic CMR index 
      tests, similar accuracy with T2 mapping and ECV, and only T1 mapping surpassed 
      it. CONCLUSIONS: Novel CMR mapping techniques provide high diagnostic accuracies 
      for the diagnosis of acute myocarditis and constitute promising successors of the 
      classic elements of the LLC for routine diagnostic protocols.
CI  - Copyright (c) 2018 American College of Cardiology Foundation. Published by Elsevier 
      Inc. All rights reserved.
FAU - Kotanidis, Christos P
AU  - Kotanidis CP
AD  - First Department of Cardiology, AHEPA Hospital, Aristotle University of 
      Thessaloniki, Thessaloniki, Greece.
FAU - Bazmpani, Maria-Anna
AU  - Bazmpani MA
AD  - First Department of Cardiology, AHEPA Hospital, Aristotle University of 
      Thessaloniki, Thessaloniki, Greece.
FAU - Haidich, Anna-Bettina
AU  - Haidich AB
AD  - Department of Hygiene and Epidemiology, Medical School, Aristotle University of 
      Thessaloniki, Greece.
FAU - Karvounis, Charalambos
AU  - Karvounis C
AD  - First Department of Cardiology, AHEPA Hospital, Aristotle University of 
      Thessaloniki, Thessaloniki, Greece.
FAU - Antoniades, Charalambos
AU  - Antoniades C
AD  - Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University 
      of Oxford, Oxford, United Kingdom.
FAU - Karamitsos, Theodoros D
AU  - Karamitsos TD
AD  - First Department of Cardiology, AHEPA Hospital, Aristotle University of 
      Thessaloniki, Thessaloniki, Greece. Electronic address: tkaramitsos@auth.gr.
LA  - eng
GR  - FS/16/15/32047/BHF_/British Heart Foundation/United Kingdom
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Systematic Review
DEP - 20180214
PL  - United States
TA  - JACC Cardiovasc Imaging
JT  - JACC. Cardiovascular imaging
JID - 101467978
SB  - IM
CIN - JACC Cardiovasc Imaging. 2018 Nov;11(11):1591-1593. PMID: 29454769
MH  - Acute Disease
MH  - Diagnosis, Differential
MH  - Humans
MH  - *Magnetic Resonance Imaging
MH  - Myocarditis/*diagnostic imaging
MH  - Predictive Value of Tests
MH  - Reproducibility of Results
OTO - NOTNLM
OT  - CMR
OT  - Lake Louise criteria
OT  - T1 mapping
OT  - T2 mapping
OT  - acute myocarditis
OT  - meta-analysis
EDAT- 2018/02/20 06:00
MHDA- 2019/11/21 06:00
CRDT- 2018/02/19 06:00
PHST- 2017/09/19 00:00 [received]
PHST- 2017/11/13 00:00 [revised]
PHST- 2017/12/06 00:00 [accepted]
PHST- 2018/02/20 06:00 [pubmed]
PHST- 2019/11/21 06:00 [medline]
PHST- 2018/02/19 06:00 [entrez]
AID - S1936-878X(17)31182-8 [pii]
AID - 10.1016/j.jcmg.2017.12.008 [doi]
PST - ppublish
SO  - JACC Cardiovasc Imaging. 2018 Nov;11(11):1583-1590. doi: 
      10.1016/j.jcmg.2017.12.008. Epub 2018 Feb 14.