PMID- 29455425
OWN - NLM
STAT- MEDLINE
DCOM- 20180612
LR  - 20221207
IS  - 1432-5233 (Electronic)
IS  - 0940-5429 (Linking)
VI  - 55
IP  - 5
DP  - 2018 May
TI  - The risk of type 2 diabetes mellitus according to the categories of body mass 
      index: the Korean Genome and Epidemiology Study (KoGES).
PG  - 479-484
LID - 10.1007/s00592-018-1112-4 [doi]
AB  - AIMS: Obesity is an established risk factor for type 2 diabetes mellitus (T2DM). 
      However, there is limited information on the pattern of relationship between the 
      risk for T2DM and body mass index (BMI) categories including underweight and 
      overweight. Thus, this study was to evaluate the risk of T2DM according to BMI 
      categories defined by Asian-specific cutoff of BMI. METHODS: 7660 non-diabetic 
      Koreans were grouped into five BMI categories (underweight, normal, overweight, 
      obese and severe obese) defined by Asian-specific cutoff of BMI and followed up 
      for 10 years to monitor the development of T2DM. With a reference of normal BMI 
      group, Cox proportional hazards assumption was used to calculate hazard ratios 
      (HRs) and their 95% confidence intervals for T2DM in five groups. Subgroup 
      analysis was conducted by gender and age (40-59 years and 60-69 years). RESULTS: 
      Baseline mean value of metabolic factors like fasting glucose, HOMA-IR, total 
      cholesterol and the proportion of impaired fasting glucose increased 
      proportionally to the level of BMI categories. Underweight group had the higher 
      proportion of impaired glucose tolerance than normal and overweight group. In all 
      subgroups, underweight, overweight, obese and severe obese group had the higher 
      HRs for T2DM than normal group, but statistical significance was only found in 
      overweight, obese and severe obese group. CONCLUSIONS: The risk of T2DM tends to 
      increase proportionally to the level of BMI categories from overweight to severe 
      obese group. Further studies should be considered to identify the incidental 
      relationship between underweight and T2DM.
FAU - Jung, Ju Young
AU  - Jung JY
AD  - Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School 
      of Medicine, 78 Saemunan-gil, Jongro-Gu, Seoul, 110-746, Republic of Korea.
FAU - Park, Sung Keun
AU  - Park SK
AD  - Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, 
      Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. 
      kkkmin7@hotmail.com.
FAU - Oh, Chang Mo
AU  - Oh CM
AD  - Departments of Preventive Medicine, School of Medicine, Kyung Hee University, 
      Seoul, Republic of Korea.
FAU - Ryoo, Jae-Hong
AU  - Ryoo JH
AD  - Departments of Preventive Medicine, School of Medicine, Kyung Hee University, 
      Seoul, Republic of Korea.
FAU - Choi, Joong-Myung
AU  - Choi JM
AD  - Departments of Preventive Medicine, School of Medicine, Kyung Hee University, 
      Seoul, Republic of Korea.
FAU - Choi, Young Joon
AU  - Choi YJ
AD  - Department of Dermatology, Kangbuk Samsung Hospital, Sungkyunkwan University 
      School of Medicine, Seoul, Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20180217
PL  - Germany
TA  - Acta Diabetol
JT  - Acta diabetologica
JID - 9200299
SB  - IM
MH  - Adult
MH  - Aged
MH  - Asian People/statistics & numerical data
MH  - *Body Mass Index
MH  - Diabetes Mellitus, Type 2/*epidemiology/*etiology
MH  - Female
MH  - Genome, Human
MH  - Glucose Intolerance/complications/epidemiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Obesity/complications/epidemiology
MH  - Overweight/complications/epidemiology
MH  - Republic of Korea/epidemiology
MH  - Risk Factors
MH  - Thinness/complications/epidemiology
OTO - NOTNLM
OT  - Body mass index
OT  - Obesity and type 2 diabetes mellitus
OT  - Underweight
EDAT- 2018/02/20 06:00
MHDA- 2018/06/13 06:00
CRDT- 2018/02/19 06:00
PHST- 2017/10/10 00:00 [received]
PHST- 2018/02/06 00:00 [accepted]
PHST- 2018/02/20 06:00 [pubmed]
PHST- 2018/06/13 06:00 [medline]
PHST- 2018/02/19 06:00 [entrez]
AID - 10.1007/s00592-018-1112-4 [pii]
AID - 10.1007/s00592-018-1112-4 [doi]
PST - ppublish
SO  - Acta Diabetol. 2018 May;55(5):479-484. doi: 10.1007/s00592-018-1112-4. Epub 2018 
      Feb 17.