PMID- 29455547
OWN - NLM
STAT- MEDLINE
DCOM- 20180605
LR  - 20180605
IS  - 0006-9248 (Print)
IS  - 0006-9248 (Linking)
VI  - 119
IP  - 2
DP  - 2018
TI  - Evaluation of fractalkine (FKN) and secreted frizzled-related protein 4 (SFRP-4) 
      serum levels in patients with prediabetes and type 2 diabetes.
PG  - 112-115
LID - 10.4149/BLL_2018_021 [doi]
AB  - OBJECTIVE: The objective of this study is to compare serum levels of FKN and 
      SFRP-4 in patients with normal glucose tolerance (NGT), impaired glucose 
      tolerance (IGT), and type 2 diabetes mellitus (T2DM). METHODS: A total of 152 
      patients presented to the endocrinology outpatient clinic of our hospital were 
      included in the study. Eighty-two patients with a history of T2DM were assigned 
      to the T2DM group. IGT (n = 34) and NGT (n = 36) groups included the patients who 
      received oral glucose tolerance test outcomes. RESULTS: Serum FKN levels were 
      significantly higher in the IGT and T2DM groups compared to the NGT group (p < 
      0.001 and p < 0.001, respectively). Serum SFRP-4 levels were significantly higher 
      in the T2DM group compared to the IGT and NGT groups (p = 0.001 and p = 0.004, 
      respectively). A significant correlation was observed between FKN and fasting 
      glucose levels. SFRP-4 was significantly correlated with fasting glucose, HbA1c, 
      and triglyceride levels. CONCLUSION: To our knowledge, increased FKN levels in 
      patients with IGT were demonstrated for the first time in this study. The results 
      of our study support the opinion that FKN and SFRP-4 may contribute to the 
      pathogenesis of T2DM (Tab. 1, Fig. 3, Ref. 23).
FAU - Baldane, S
AU  - Baldane S
FAU - Ipekci, S H
AU  - Ipekci SH
FAU - Ekin, A
AU  - Ekin A
FAU - Abusoglu, S
AU  - Abusoglu S
FAU - Unlu, A
AU  - Unlu A
FAU - Kebapcilar, L
AU  - Kebapcilar L
LA  - eng
PT  - Journal Article
PL  - Slovakia
TA  - Bratisl Lek Listy
JT  - Bratislavske lekarske listy
JID - 0065324
RN  - 0 (Blood Glucose)
RN  - 0 (CX3CL1 protein, human)
RN  - 0 (Chemokine CX3CL1)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (SFRP4 protein, human)
SB  - IM
MH  - Blood Glucose/*metabolism
MH  - Chemokine CX3CL1/*metabolism
MH  - Diabetes Mellitus, Type 2/*metabolism
MH  - Fasting
MH  - Female
MH  - Glucose Intolerance/*metabolism
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prediabetic State/*metabolism
MH  - Proto-Oncogene Proteins/*metabolism
OTO - NOTNLM
OT  - inflammation
OT  - insulin secretion
OT  - secreted frizzled-related protein 4 fractalkine.
EDAT- 2018/02/20 06:00
MHDA- 2018/06/06 06:00
CRDT- 2018/02/20 06:00
PHST- 2018/02/20 06:00 [entrez]
PHST- 2018/02/20 06:00 [pubmed]
PHST- 2018/06/06 06:00 [medline]
AID - 10.4149/BLL_2018_021 [doi]
PST - ppublish
SO  - Bratisl Lek Listy. 2018;119(2):112-115. doi: 10.4149/BLL_2018_021.