PMID- 29455565
OWN - NLM
STAT- MEDLINE
DCOM- 20181030
LR  - 20181030
IS  - 1471-1753 (Electronic)
IS  - 0954-6634 (Linking)
VI  - 29
IP  - 7
DP  - 2018 Nov
TI  - Pulsed dye laser versus intense pulsed light in melasma: a split-face comparative 
      study.
PG  - 725-732
LID - 10.1080/09546634.2018.1441487 [doi]
AB  - BACKGROUND: Recent reports suggest that melasma may have a vascular component. 
      Vascular targeting lasers and light treatment can be a therapeutic option that 
      will provide benefits to the patients. OBJECTIVES: To compare the efficacy and 
      tolerability of pulsed dye laser (PDL) and intense pulsed light in treatment of 
      melasma. PATIENTS AND METHODS: Twenty-eight Egyptian female patients with melasma 
      were treated with PDL on the right hemiface (Group A) and with the intense pulsed 
      light on the left hemiface (Group B). Clinical assessment was performed according 
      to the hemifacial modified Melasma Area and Severity Index score (mMASI). Tissue 
      biopsies were taken from patients for immunohistochemical staining with vascular 
      endothelial growth factor (VEGF) antibody. RESULTS: The hemifacial mMASI score 
      was significantly reduced after treatment in studied groups with no statistically 
      significant difference. Intense pulsed light (IPL) group showed higher efficacy 
      of treatment than PDL group in the epidermal melasma and in melasma lesions which 
      had a vascular component. The expression level and intensity score of VEGF were 
      significantly reduced after treatment in both groups. CONCLUSIONS: Both PDL and 
      IPL were effective and safe treatment modalities for lightening of melasma. VEGF 
      can be proved as a possible mechanism underlying the action of both PDL and IPL 
      on melasma.
FAU - Hassan, Arwa M
AU  - Hassan AM
AD  - a Dermatology and Venereology Department , Tanta University , Tanta , Egypt.
FAU - Elfar, Nashwa N
AU  - Elfar NN
AD  - a Dermatology and Venereology Department , Tanta University , Tanta , Egypt.
FAU - Rizk, Omnia M
AU  - Rizk OM
AD  - b Department of Pathology , Tanta University , Tanta , Egypt.
FAU - Eissa, Nahed Y
AU  - Eissa NY
AD  - a Dermatology and Venereology Department , Tanta University , Tanta , Egypt.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20180223
PL  - England
TA  - J Dermatolog Treat
JT  - The Journal of dermatological treatment
JID - 8918133
RN  - 0 (Vascular Endothelial Growth Factor A)
SB  - IM
MH  - Adult
MH  - Epidermis/pathology
MH  - Female
MH  - Humans
MH  - Lasers, Dye/*therapeutic use
MH  - Low-Level Light Therapy
MH  - Melanosis/pathology/*therapy
MH  - Middle Aged
MH  - Severity of Illness Index
MH  - Treatment Outcome
MH  - Vascular Endothelial Growth Factor A/metabolism
OTO - NOTNLM
OT  - Pulsed dye laser
OT  - VEGF
OT  - intense pulsed light
OT  - melasma
EDAT- 2018/02/20 06:00
MHDA- 2018/10/31 06:00
CRDT- 2018/02/20 06:00
PHST- 2018/02/20 06:00 [pubmed]
PHST- 2018/10/31 06:00 [medline]
PHST- 2018/02/20 06:00 [entrez]
AID - 10.1080/09546634.2018.1441487 [doi]
PST - ppublish
SO  - J Dermatolog Treat. 2018 Nov;29(7):725-732. doi: 10.1080/09546634.2018.1441487. 
      Epub 2018 Feb 23.