PMID- 29455792
OWN - NLM
STAT- MEDLINE
DCOM- 20180720
LR  - 20190107
IS  - 2213-3763 (Electronic)
IS  - 0019-4832 (Print)
IS  - 0019-4832 (Linking)
VI  - 70
IP  - 1
DP  - 2018 Jan-Feb
TI  - Left ventricular structure and diastolic function by cardiac magnetic resonance 
      imaging in hypertrophic cardiomyopathy.
PG  - 75-81
LID - S0019-4832(16)30366-2 [pii]
LID - 10.1016/j.ihj.2016.12.021 [doi]
AB  - OBJECTIVE: Diastolic dysfunction is common in hypertrophic cardiomyopathy (HCM) 
      and hypertensive heart disease (HHD), but its relationships with left ventricular 
      (LV) parameters have not been well studied. Our objective was to assess the 
      relationship of various measures of diastolic function, and maximum left 
      ventricular wall thickness (MLVWT) and left ventricular mass index (LVMI) in HCM, 
      HHD and normal controls using cardiac magnetic resonance imaging (CMR). We also 
      assessed LV parameters and diastolic function in relation to late gadolinium 
      enhancement (LGE) and right ventricular (RV) hypertrophy in HCM. METHODS: 41 
      patients with HCM, 21 patients with HHD and 20 controls were studied. Peak 
      filling rate (PFR), time to peak filling (TPF), MLVWT and LVMI were measured 
      using CMR. LGE and RV morphology were assessed in HCM patients. RESULTS: MLVWT 
      correlated with TPF in HCM (r=0.38; p=0.02), HHD (r=0.58; p=0.01) and controls 
      (r=0.54; p=0.01); correlation between MLVWT and TPF was weaker in HCM than HHD. 
      LVMI did not correlate with diastolic function. In HCM, LGE extent correlated 
      with MLVWT (tau=0.41; p=0.002) and with TPF (tau=0.29; p=0.02). The HCM patients with 
      RV hypertrophy had higher MLVWT (p<0.001) and TPF (p=0.03) than patients without 
      RV hypertrophy. CONCLUSION: MLVWT correlates with diastolic function (TPF) in 
      HCM, HHD and controls. LVMI did not show significant correlation with TPF. The 
      diastolic dysfunction in HCM is not entirely explained by wall thickening. LGE 
      and RV involvement are associated with worse LV diastolic function, suggesting 
      that these may be markers of more severe underlying myocardial disarray and 
      fibrosis that contribute to diastolic dysfunction.
CI  - Copyright (c) 2016. Published by Elsevier B.V.
FAU - Chacko, Binita Riya
AU  - Chacko BR
AD  - Department of Medical Imaging, St. Michael's Hospital, Toronto, Canada; 
      Department of Radiology, Christian Medical College, Vellore, Tamil Nadu, India.
FAU - Karur, Gauri R
AU  - Karur GR
AD  - Department of Medical Imaging, St. Michael's Hospital, Toronto, Canada.
FAU - Connelly, Kim A
AU  - Connelly KA
AD  - Terrence Donnelly Heart Centre, St Michael's Hospital, Toronto, Canada; 
      University of Toronto, Toronto, Canada.
FAU - Yan, Raymond T
AU  - Yan RT
AD  - University of Toronto, Toronto, Canada.
FAU - Kirpalani, Anish
AU  - Kirpalani A
AD  - Department of Medical Imaging, St. Michael's Hospital, Toronto, Canada; 
      University of Toronto, Toronto, Canada.
FAU - Wald, Rachel
AU  - Wald R
AD  - University of Toronto, Toronto, Canada; Division of Cardiology, Toronto General 
      Hospital, Toronto, Canada.
FAU - Jimenez-Juan, Laura
AU  - Jimenez-Juan L
AD  - Department of Medical Imaging, Sunnybrook Health Sciences Centre, Toronto, 
      Canada.
FAU - Jacob, John Roshan
AU  - Jacob JR
AD  - Department of Cardiology, Christian Medical College Hospital, Vellore, Tamil 
      Nadu, India.
FAU - Deva, Djeven P
AU  - Deva DP
AD  - Department of Medical Imaging, St. Michael's Hospital, Toronto, Canada; 
      University of Toronto, Toronto, Canada.
FAU - Yan, Andrew T
AU  - Yan AT
AD  - Terrence Donnelly Heart Centre, St Michael's Hospital, Toronto, Canada; 
      University of Toronto, Toronto, Canada. Electronic address: yana@smh.ca.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Observational Study
DEP - 20170106
PL  - India
TA  - Indian Heart J
JT  - Indian heart journal
JID - 0374675
SB  - IM
MH  - Cardiomyopathy, Hypertrophic/*diagnosis/physiopathology
MH  - Child
MH  - Child, Preschool
MH  - Diastole
MH  - Echocardiography, Doppler, Color
MH  - Female
MH  - Heart Ventricles/*diagnostic imaging/physiopathology
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Male
MH  - Myocardium/*pathology
MH  - Retrospective Studies
MH  - Ventricular Function, Left/*physiology
PMC - PMC5902823
OTO - NOTNLM
OT  - Diastolic function
OT  - Hypertension
OT  - Hypertrophic cardiomyopathy
OT  - Left ventricle
OT  - Magnetic resonance imaging
EDAT- 2018/02/20 06:00
MHDA- 2018/07/22 06:00
PMCR- 2019/01/01
CRDT- 2018/02/20 06:00
PHST- 2016/08/12 00:00 [received]
PHST- 2016/11/01 00:00 [revised]
PHST- 2016/12/28 00:00 [accepted]
PHST- 2018/02/20 06:00 [entrez]
PHST- 2018/02/20 06:00 [pubmed]
PHST- 2018/07/22 06:00 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - S0019-4832(16)30366-2 [pii]
AID - 10.1016/j.ihj.2016.12.021 [doi]
PST - ppublish
SO  - Indian Heart J. 2018 Jan-Feb;70(1):75-81. doi: 10.1016/j.ihj.2016.12.021. Epub 
      2017 Jan 6.