PMID- 29456680
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 15
IP  - 3
DP  - 2018 Mar
TI  - Correlation of vitamin D receptor with bronchial asthma in children.
PG  - 2773-2776
LID - 10.3892/etm.2018.5739 [doi]
AB  - This study was designed to investigate the correlation of vitamin D receptor 
      (VDR) gene polymorphism with bronchial asthma in children. Seventy patients 
      admitted to Daqing Longnan Hospital and diagnosed as bronchial asthma for the 
      first time from April 2015 to May 2017 were selected as observation group. 
      Patients received routine treatment and intervention. Seventy healthy subjects 
      admitted to hospital during the same period were enrolled as the control group. 
      Vitamin D gene polymorphism was detected by polymerase chain reaction-restriction 
      fragment length polymorphism assay; the levels of total serum immunoglobulin E 
      (IgE) in the two groups were determined by electrochemiluminescence immunoassay; 
      lung function levels in patients were measured using PowerCube (Germany) 
      pulmonary function instrument before and after treatment, and the relationship 
      between VDR gene polymorphism and lung function in children with bronchial asthma 
      was analyzed. The difference in comparison of base frequency of rs1544410 locus 
      of VDR gene had no statistical significance between the two groups (P>0.05). The 
      locus CC frequency of rs7975232 of VDR gene in observation group was lower in the 
      observation group than that in the control group (P<0.05); the locus AC and AA 
      frequencies of rs7975232 of VDR gene were higher in the observation group than 
      those in the control group (P<0.05). The level of vitamin D was lower in the 
      observation group than that in the control group (P<0.05); the level of total 
      serum IgE was higher in the observation group than that in the control group 
      (P<0.05). The forced expiratory volume in 1 sec (FEV1), peak expiratory flow 
      (PEF) and the ratio of FEV1 to forced vital capacity (FVC) in children with 
      bronchial asthma in the observation group were higher after treatment than those 
      before treatment (P<0.05). The correlation research displayed that VDR gene 
      polymorphism was negatively correlated with lung function levels in children with 
      bronchial asthma (P<0.05). The results showed that children with bronchial asthma 
      are often accompanied by different degrees of changes in VDR gene polymorphism, 
      which is negatively correlated with the severity of asthma, so vitamin D should 
      be strengthened to ameliorate the prognosis of children.
FAU - Hou, Chunlei
AU  - Hou C
AD  - Department of Pediatrics, Daqing Longnan Hospital, Daqing, Heilongjiang 163453, 
      P.R. China.
FAU - Zhu, Xiaoli
AU  - Zhu X
AD  - Department of Pediatrics, Daqing Longnan Hospital, Daqing, Heilongjiang 163453, 
      P.R. China.
FAU - Chang, Xiangyun
AU  - Chang X
AD  - Department of Pediatrics, Daqing Longnan Hospital, Daqing, Heilongjiang 163453, 
      P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20180111
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC5795668
OTO - NOTNLM
OT  - bronchial asthma in children
OT  - correlation
OT  - vitamin D receptor
EDAT- 2018/02/20 06:00
MHDA- 2018/02/20 06:01
PMCR- 2018/01/11
CRDT- 2018/02/20 06:00
PHST- 2017/08/11 00:00 [received]
PHST- 2017/12/11 00:00 [accepted]
PHST- 2018/02/20 06:00 [entrez]
PHST- 2018/02/20 06:00 [pubmed]
PHST- 2018/02/20 06:01 [medline]
PHST- 2018/01/11 00:00 [pmc-release]
AID - ETM-0-0-5739 [pii]
AID - 10.3892/etm.2018.5739 [doi]
PST - ppublish
SO  - Exp Ther Med. 2018 Mar;15(3):2773-2776. doi: 10.3892/etm.2018.5739. Epub 2018 Jan 
      11.