PMID- 29456697
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 15
IP  - 3
DP  - 2018 Mar
TI  - Relationship between fat mass and obesity-associated gene expression and type 2 
      diabetes mellitus severity.
PG  - 2917-2921
LID - 10.3892/etm.2018.5752 [doi]
AB  - This study sought to investigate any correlation between fat mass and 
      obesity-associated gene (FTO) expression and the severity of type 2 diabetes 
      mellitus (T2DM). In total 110 patients newly diagnosed with T2DM in the 
      outpatient department of Yantai Yuhuangding Hospital between September 2016 and 
      March 2017 were selected as study subjects and were divided into severe (58 
      cases) and mild groups (52 cases) according to T2DM severity. Patients in the 
      severe group were followed up for 12 weeks. An additional 60 healthy individuals 
      were selected to serve as the normal control group. Fasting plasma glucose (FPG), 
      fasting insulin (FINs), fasting C-peptide (FCP), glycosylated hemoglobin (HbA1c) 
      and homeostasis model assessment of insulin resistance (HOMA-IR) were examined 
      for every patient in the study. Real-time polymerase chain reaction (RT-PCR) was 
      used to detect FTO messenger ribonucleic acid (mRNA) expression levels in patient 
      peripheral blood lymphocytes. Western blotting was used to detect serum FTO 
      protein expression levels, upon which the correlation between FTO protein levels 
      and all other indices were analyzed. Compared with the normal control group, both 
      T2DM groups showed significantly increased waist circumferences, hip 
      circumferences, body mass indexes (BMIs), blood glucose indexes (FPG, FCP, HbA1c, 
      FINs, HOMA-IR) and FTO mRNA/protein levels (p<0.05). Additionally, the increases 
      presented by the severe T2DM group were significantly greater than those 
      presented by the mild T2DM group (p<0.05). After 12 weeks of treatment, the 
      severe T2DM group showed decreased BMI, blood glucose index and FTO protein 
      expression (p<0.05). FTO protein expression in T2DM patients was higher than in 
      healthy controls, with severe patients showing greater expression levels than 
      mild group patients. FTO expression was positively correlated with BMI, waist 
      circumference, chest circumference, FPG, FCP, HbA1c, FINs and HOMA-IR. Therefore, 
      FTO expression can serve as a marker for the clinical diagnosis and treatment of 
      T2DM.
FAU - Wang, Qiuling
AU  - Wang Q
AD  - Department of Endocrinology, Yantai Yuhuangding Hospital, Yantai, Shandong 
      264000, P.R. China.
FAU - Wang, Jinhuan
AU  - Wang J
AD  - Department of Health, Yantai Yuhuangding Hospital, Yantai, Shandong 264000, P.R. 
      China.
FAU - Lin, Haixia
AU  - Lin H
AD  - Department of Endocrinology, Yantai Yuhuangding Hospital, Yantai, Shandong 
      264000, P.R. China.
FAU - Huo, Xuechen
AU  - Huo X
AD  - Department of Biliary Surgery, Yantai Yuhuangding Hospital, Yantai, Shandong 
      264000, P.R. China.
FAU - Zhu, Qiaoling
AU  - Zhu Q
AD  - Department of Pharmacy, Yantai Yuhuangding Hospital, Yantai, Shandong 264000, 
      P.R. China.
FAU - Zhang, Min
AU  - Zhang M
AD  - Neurological Intensive Care Unit, Yantai Yuhuangding Hospital, Yantai, Shandong 
      264000, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20180115
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC5795504
OTO - NOTNLM
OT  - FTO
OT  - obesity
OT  - type 2 diabetes mellitus
EDAT- 2018/02/20 06:00
MHDA- 2018/02/20 06:01
PMCR- 2018/01/15
CRDT- 2018/02/20 06:00
PHST- 2017/07/06 00:00 [received]
PHST- 2017/11/21 00:00 [accepted]
PHST- 2018/02/20 06:00 [entrez]
PHST- 2018/02/20 06:00 [pubmed]
PHST- 2018/02/20 06:01 [medline]
PHST- 2018/01/15 00:00 [pmc-release]
AID - ETM-0-0-5752 [pii]
AID - 10.3892/etm.2018.5752 [doi]
PST - ppublish
SO  - Exp Ther Med. 2018 Mar;15(3):2917-2921. doi: 10.3892/etm.2018.5752. Epub 2018 Jan 
      15.