PMID- 29456744
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1792-1074 (Print)
IS  - 1792-1082 (Electronic)
IS  - 1792-1074 (Linking)
VI  - 15
IP  - 3
DP  - 2018 Mar
TI  - Cardamonin enhances the anti-proliferative effect of cisplatin on ovarian cancer.
PG  - 3991-3997
LID - 10.3892/ol.2018.7743 [doi]
AB  - The mammalian target of rapamycin (mTOR) is well-known as a promising therapeutic 
      target in various cancer cells. mTOR activation decreases the sensitivity of 
      ovarian cancer to cisplatin. Cardamonin inhibits the proliferation of various 
      cancer cells by mTOR suppression. The present study examined whether cardamonin 
      combined with cisplatin is efficacious for the anti-proliferation of ovarian 
      cancer cells. The anti-proliferative effect was determined by MTT and cell cycle 
      assays. Activation of the mTOR signal pathway and the expression of 
      anti-apoptotic proteins were evaluated by western blot analysis. Cardamonin 
      significantly enhanced the effects of cisplatin on cell proliferation and cell 
      cycle progression. The expression of B cell lymphoma-2, X-linked inhibitor of 
      apoptosis protein and Survivin was significantly decreased following combination 
      treatment. Furthermore, the activation of mTOR and its downstream 70 kDa 
      ribosomal protein S6 kinase was inhibited by cardamonin. These results 
      demonstrated that the combinatorial effects of cardamonin and cisplatin on 
      anti-proliferation were enhanced by suppressing the expression of anti-apoptotic 
      proteins and activation of mTOR in ovarian cancer cells.
FAU - Niu, Peiguang
AU  - Niu P
AD  - Department of Pharmacy, Fujian Provincial Maternity and Children Hospital, 
      Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350001, P.R. 
      China.
FAU - Shi, Daohua
AU  - Shi D
AD  - Department of Pharmacy, Fujian Provincial Maternity and Children Hospital, 
      Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350001, P.R. 
      China.
FAU - Zhang, Shusheng
AU  - Zhang S
AD  - Department of Pharmacy, Fujian Provincial Maternity and Children Hospital, 
      Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350001, P.R. 
      China.
FAU - Zhu, Yanting
AU  - Zhu Y
AD  - Department of Pharmacy, Fujian Provincial Maternity and Children Hospital, 
      Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350001, P.R. 
      China.
FAU - Zhou, Jintuo
AU  - Zhou J
AD  - Department of Pharmacy, Fujian Provincial Maternity and Children Hospital, 
      Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350001, P.R. 
      China.
LA  - eng
PT  - Journal Article
DEP - 20180108
PL  - Greece
TA  - Oncol Lett
JT  - Oncology letters
JID - 101531236
PMC - PMC5795861
OTO - NOTNLM
OT  - apoptosis
OT  - cardamonin
OT  - cisplatin
OT  - mammalian target of rapamycin
OT  - ovarian cancer
EDAT- 2018/02/20 06:00
MHDA- 2018/02/20 06:01
PMCR- 2018/01/08
CRDT- 2018/02/20 06:00
PHST- 2016/08/15 00:00 [received]
PHST- 2017/09/09 00:00 [accepted]
PHST- 2018/02/20 06:00 [entrez]
PHST- 2018/02/20 06:00 [pubmed]
PHST- 2018/02/20 06:01 [medline]
PHST- 2018/01/08 00:00 [pmc-release]
AID - OL-0-0-7743 [pii]
AID - 10.3892/ol.2018.7743 [doi]
PST - ppublish
SO  - Oncol Lett. 2018 Mar;15(3):3991-3997. doi: 10.3892/ol.2018.7743. Epub 2018 Jan 8.