PMID- 29457485
OWN - NLM
STAT- MEDLINE
DCOM- 20181218
LR  - 20181218
IS  - 1615-7109 (Electronic)
IS  - 1203-4754 (Linking)
VI  - 22
IP  - 4
DP  - 2018 Jul/Aug
TI  - Atopy Associated With Positive Patch Test and Possible Allergic Contact 
      Dermatitis.
PG  - 405-410
LID - 10.1177/1203475418758988 [doi]
AB  - BACKGROUND: Atopy is a genetic predisposition to the development of allergic 
      reactions and the increased production of immunoglobulin E (IgE) upon exposure to 
      environmental antigens. Clinical manifestations of atopy include asthma, atopic 
      dermatitis (AD), and allergic rhinoconjunctivitis (ARC). OBJECTIVE: To determine 
      if cutaneous delayed hypersensitivity reactions (CDHRs) as assessed by patch 
      testing are higher among patients with a history of atopy and with a familial 
      predisposition to atopy. METHODS: For this study, we reviewed the patch test 
      database of the UBC Contact Dermatitis Clinic over a 4-year time span. A personal 
      history of asthma, AD, and ARC was recorded. In addition, a family history was 
      obtained and manifestations of atopy in family members were noted. RESULTS: A 
      total of 1515 patients were included in this study. Our data show that the odds 
      ratio (OR) of a positive patch test with a personal history of atopy was 1.39, 
      while the OR of a positive patch test with a family history of atopy was 1.69. 
      Conversely, a personal history of respiratory atopy did not significantly affect 
      the probability of a positive patch test, with an OR of 1.03. CONCLUSION: We 
      conclude from our study that patients with a personal or family history of atopy 
      have an increased risk of allergic contact dermatitis (ACD). These results 
      provide further evidence for the link between atopy and ACD and suggest that 
      children of atopic parents should avoid potential contact allergens and would 
      likely benefit from prophylactic emollient use.
FAU - Kirchhof, Mark G
AU  - Kirchhof MG
AD  - 1 Division of Dermatology, Department of Medicine, University of Ottawa and The 
      Ottawa Hospital, Ottawa, ON, Canada.
FAU - de Gannes, Gillian C
AU  - de Gannes GC
AD  - 2 Department of Dermatology and Skin Science, University of British Columbia, 
      Vancouver, BC, Canada.
AD  - 3 Division of Dermatology, Department of Medicine, St. Paul's Hospital, 
      Vancouver, BC, Canada.
LA  - eng
PT  - Journal Article
DEP - 20180218
PL  - United States
TA  - J Cutan Med Surg
JT  - Journal of cutaneous medicine and surgery
JID - 9614685
SB  - IM
MH  - Asthma/complications/epidemiology
MH  - Dermatitis, Allergic Contact/*complications/*epidemiology
MH  - Dermatitis, Atopic/*complications/*epidemiology
MH  - Humans
MH  - Odds Ratio
MH  - Patch Tests/*statistics & numerical data
MH  - Retrospective Studies
OTO - NOTNLM
OT  - allergic contact dermatitis
OT  - atopic dermatitis
OT  - atopic triad
OT  - atopy
OT  - cutaneous delayed hypersensitivity reaction
EDAT- 2018/02/20 06:00
MHDA- 2018/12/19 06:00
CRDT- 2018/02/20 06:00
PHST- 2018/02/20 06:00 [pubmed]
PHST- 2018/12/19 06:00 [medline]
PHST- 2018/02/20 06:00 [entrez]
AID - 10.1177/1203475418758988 [doi]
PST - ppublish
SO  - J Cutan Med Surg. 2018 Jul/Aug;22(4):405-410. doi: 10.1177/1203475418758988. Epub 
      2018 Feb 18.