PMID- 29457593
OWN - NLM
STAT- MEDLINE
DCOM- 20180821
LR  - 20180821
IS  - 1878-3619 (Electronic)
IS  - 0959-2989 (Linking)
VI  - 29
IP  - 2
DP  - 2018
TI  - Characterization study and optimization of swelling behavior for 
      p(HEMA-co-Eudragit L-100) hydrogels by using Taguchi Method.
PG  - 191-203
LID - 10.3233/BME-171722 [doi]
AB  - The aim of this study is to produce the smart hydrogel to use insulin release for 
      human body. p(HEMA-co-Eudragit L-100) hydrogels containing different ratios of 
      2-Hydroxyethyl methacrylate (HEMA) and Eudragait L-100 were synthesized by using 
      ammonium persulfate (APS) as an initiator and ethylene glycol dimethacrylate 
      (EGDMA) as a cross linker. The structures of hydrogels produced were 
      characterized by using Fourier Transform Infrared Spectroscopy (FT-IR) and 
      Scanning electron microscope (SEM) analysis. In this way, optimum synthesis 
      conditions were determined for p(HEMA-co-Eudragit L-100) hydrogels by using 
      Taguchi method as an optimization method. The gelling percentages of all 
      hydrogels were calculated. After all, the swelling behaviors (%) of hydrogels 
      were investigated in range of various times (1-44 hrs), temperatures (20-50 degrees C) 
      and pH (2-12) and the optimum process conditions in the production of hydrogels 
      were determined. Consequently, the optimum time, temperature and pH were 24 
      hours, 37 degrees C and 7, respectively. Thus, this hydrogel could be evaluated in 
      insulin release for diabetes treatment and drug industry.
FAU - Ozgunduz, Hediye Irem
AU  - Ozgunduz HI
AD  - Department of Chemical Engineering, Yildiz Technical University, Davutpasa St., 
      N.127, Esenler, Istanbul, Turkey.
FAU - Ozturk, Abdullah Bilal
AU  - Ozturk AB
AD  - Department of Chemical Engineering, Yildiz Technical University, Davutpasa St., 
      N.127, Esenler, Istanbul, Turkey.
FAU - Kandilci, Hava Gizem
AU  - Kandilci HG
AD  - Department of Chemical Engineering, Yildiz Technical University, Davutpasa St., 
      N.127, Esenler, Istanbul, Turkey.
FAU - Acarali, Nil
AU  - Acarali N
AD  - Department of Chemical Engineering, Yildiz Technical University, Davutpasa St., 
      N.127, Esenler, Istanbul, Turkey.
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Biomed Mater Eng
JT  - Bio-medical materials and engineering
JID - 9104021
RN  - 0 (Cross-Linking Reagents)
RN  - 0 (Delayed-Action Preparations)
RN  - 0 (Hydrogels)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Insulin)
RN  - 0 (Methacrylates)
RN  - 0 (Polymethacrylic Acids)
RN  - 059QF0KO0R (Water)
RN  - 25086-15-1 (methylmethacrylate-methacrylic acid copolymer)
RN  - 6E1I4IV47V (hydroxyethyl methacrylate)
RN  - 7BK5G69305 (ethylene dimethacrylate)
SB  - IM
MH  - Cross-Linking Reagents/chemistry
MH  - Delayed-Action Preparations/*chemistry
MH  - Humans
MH  - Hydrogels/*chemistry
MH  - Hydrogen-Ion Concentration
MH  - Hypoglycemic Agents/*administration & dosage
MH  - Insulin/*administration & dosage
MH  - Methacrylates/*chemistry
MH  - Polymethacrylic Acids/*chemistry
MH  - Spectroscopy, Fourier Transform Infrared
MH  - Temperature
MH  - Water/chemistry
OTO - NOTNLM
OT  - Hydrogel
OT  - optimization
OT  - spectroscopy
OT  - structure
EDAT- 2018/02/20 06:00
MHDA- 2018/08/22 06:00
CRDT- 2018/02/20 06:00
PHST- 2018/02/20 06:00 [entrez]
PHST- 2018/02/20 06:00 [pubmed]
PHST- 2018/08/22 06:00 [medline]
AID - BME1722 [pii]
AID - 10.3233/BME-171722 [doi]
PST - ppublish
SO  - Biomed Mater Eng. 2018;29(2):191-203. doi: 10.3233/BME-171722.