PMID- 29457930
OWN - NLM
STAT- MEDLINE
DCOM- 20190821
LR  - 20190821
IS  - 2169-141X (Electronic)
IS  - 2169-1401 (Linking)
VI  - 46
IP  - sup1
DP  - 2018
TI  - Nano-loaded human umbilical cord mesenchymal stem cells as targeted carriers of 
      doxorubicin for breast cancer therapy.
PG  - 642-652
LID - 10.1080/21691401.2018.1434185 [doi]
AB  - The main challenge of anticancer drugs is poor tumor targeting. Now cellular 
      carriers are widely investigated to deliver anticancer agents. As an ideal 
      cellular candidate, human umbilical cord derived mesenchymal stem cells 
      (hUC-MSCs) possess inherent tropism potential to tumor. Here, we constructed 
      hUC-MSCs carrying transferrin-inspired-nanoparticles that contain 
      doxorubicin(hUC-MSCs-Tf-inspired-NPs) to achieve enhanced anti-tumor efficacy and 
      made an evaluation. Results represented that hUC-MSCs-Tf-inspired-NPs not only 
      exhibit the controlled-release property of Tf-inspired-NPs, but also integrate 
      tumor tropism and penetrative abilities of MSCs. The tumor volume of nude mice 
      bearing breast cancer MCF-7 treated with hUC-MSCs-Tf-inspired-NPs, was remarkably 
      reduced compared to those treated with free drug or Tf-inspired-NPs. Thus, 
      Tf-inspired-NPs loaded hUC-MSCs have a potential to deliver anticancer drugs.
FAU - Cao, Shunxiu
AU  - Cao S
AD  - a School of Life Science and Technology , China Pharmaceutical University , 
      Nanjing , China.
FAU - Guo, Jiamin
AU  - Guo J
AD  - a School of Life Science and Technology , China Pharmaceutical University , 
      Nanjing , China.
FAU - He, Yujing
AU  - He Y
AD  - b Department of Pharmaceutics , China Pharmaceutical University , Nanjing , 
      China.
FAU - Alahdal, Murad
AU  - Alahdal M
AD  - a School of Life Science and Technology , China Pharmaceutical University , 
      Nanjing , China.
FAU - Tang, Shanshan
AU  - Tang S
AD  - a School of Life Science and Technology , China Pharmaceutical University , 
      Nanjing , China.
FAU - Zhao, Yuekui
AU  - Zhao Y
AD  - a School of Life Science and Technology , China Pharmaceutical University , 
      Nanjing , China.
FAU - Yang, Zhaocong
AU  - Yang Z
AD  - a School of Life Science and Technology , China Pharmaceutical University , 
      Nanjing , China.
FAU - Gao, Huashan
AU  - Gao H
AD  - a School of Life Science and Technology , China Pharmaceutical University , 
      Nanjing , China.
FAU - Hu, Wenjun
AU  - Hu W
AD  - a School of Life Science and Technology , China Pharmaceutical University , 
      Nanjing , China.
FAU - Jiang, Hulin
AU  - Jiang H
AD  - b Department of Pharmaceutics , China Pharmaceutical University , Nanjing , 
      China.
FAU - Qin, Lianju
AU  - Qin L
AD  - c First Affiliated Hospital , Nanjing Medical University , Nanjing , China.
FAU - Jin, Liang
AU  - Jin L
AD  - a School of Life Science and Technology , China Pharmaceutical University , 
      Nanjing , China.
LA  - eng
PT  - Journal Article
DEP - 20180219
PL  - England
TA  - Artif Cells Nanomed Biotechnol
JT  - Artificial cells, nanomedicine, and biotechnology
JID - 101594777
RN  - 0 (Drug Carriers)
RN  - 80168379AG (Doxorubicin)
MH  - Animals
MH  - Breast Neoplasms/*drug therapy/pathology
MH  - Doxorubicin/*metabolism/*pharmacology/therapeutic use
MH  - Drug Carriers/*chemistry/metabolism
MH  - Drug Liberation
MH  - Female
MH  - Humans
MH  - MCF-7 Cells
MH  - Mesenchymal Stem Cells/*chemistry/cytology/metabolism
MH  - Mice
MH  - Mice, Nude
MH  - Molecular Targeted Therapy
MH  - Nanostructures/*chemistry
MH  - Umbilical Cord/*cytology
OTO - NOTNLM
OT  - doxorubicin
OT  - targeted delivery
OT  - Mesenchymal stem cells
OT  - artificial cells
OT  - breast cancer
OT  - nanoparticles
EDAT- 2018/02/20 06:00
MHDA- 2019/08/23 06:00
CRDT- 2018/02/20 06:00
PHST- 2018/02/20 06:00 [pubmed]
PHST- 2019/08/23 06:00 [medline]
PHST- 2018/02/20 06:00 [entrez]
AID - 10.1080/21691401.2018.1434185 [doi]
PST - ppublish
SO  - Artif Cells Nanomed Biotechnol. 2018;46(sup1):642-652. doi: 
      10.1080/21691401.2018.1434185. Epub 2018 Feb 19.