PMID- 29458359
OWN - NLM
STAT- MEDLINE
DCOM- 20181217
LR  - 20181217
IS  - 1476-069X (Electronic)
IS  - 1476-069X (Linking)
VI  - 17
IP  - 1
DP  - 2018 Feb 20
TI  - In-utero exposure to phenols and phthalates and the intelligence quotient of boys 
      at 5 years.
PG  - 17
LID - 10.1186/s12940-018-0359-0 [doi]
LID - 17
AB  - BACKGROUND: There are concerns that developmental exposure to endocrine 
      disrupting chemicals such as phenolic compounds and phthalates could affect child 
      cognitive function. Epidemiological studies tackling this question have mainly 
      focused on phthalate metabolites and bisphenol A, but not on the other phenolic 
      compounds. Our study aimed to assess the relationship between in-utero exposure 
      to phthalates, bisphenol A and other phenolic compounds (parabens, triclosan, 
      dichlorophenols and benzophenone-3) and the Intelligence Quotient (IQ) of boys at 
      5-6 years. METHODS: In 452 mother-son dyads from the French EDEN cohort, we 
      measured 11 phthalate metabolites and 9 phenolic compounds (4 parabens, 
      benzophenone-3, bisphenol A, 2 dichlorophenols and triclosan) in spot urine 
      samples collected between 22 and 29 gestational weeks. Verbal and performance IQ 
      of children were assessed at 5-6 years by a psychologist using the Wechsler 
      Preschool and Primary Scale of Intelligence (WPPSI). We used adjusted Structural 
      Equation Models (SEM) combined with Benjamini and Hochberg false discovery rate 
      correction to assess the associations between maternal urine phenol and phthalate 
      metabolite concentrations considered simultaneously and the boys' IQ. RESULTS: No 
      phenol or phthalate metabolite concentration was negatively associated with the 
      boys' verbal or performance IQ (uncorrected p-values >/=0.09). 
      Mono(3-carboxypropyl) phthalate tended to be associated with increased verbal IQ 
      (beta = 0.136, 95% confidence interval, 0.01; 0.27). This association disappeared 
      after correction for multiple comparison (corrected p-value, 0.71). CONCLUSION: 
      Our results did not provide evidence of an inverse association between in-utero 
      exposure to phenols or phthalates and verbal and performance IQ among boys. Since 
      phenols and phthalates may have sex-specific effects, these null findings cannot 
      be generalized to girls. Limitations included use of a single spot urine sample 
      to assess exposures and lack of consideration of postnatal exposures.
FAU - Nakiwala, Dorothy
AU  - Nakiwala D
AUID- ORCID: 0000-0002-2563-1162
AD  - Institute for Advanced Biosciences (IAB), INSERM U1209, CNRS UMR 5309, Universite 
      Grenoble Alpes, 38000, Grenoble, France. dorothy.nakiwala@univ-grenoble-alpes.fr.
FAU - Peyre, Hugo
AU  - Peyre H
AD  - Assistance Publique-Hopitaux de Paris, Robert Debre Hospital, Child and 
      Adolescent Psychiatry Department, Paris, France.
AD  - Cognitive Sciences and Psycholinguistic Laboratory, Ecole Normale Superieure, 
      Paris, France.
FAU - Heude, Barbara
AU  - Heude B
AD  - U1153 Epidemiology and Biostatistics Sorbonne Paris Cite Research Centre (CRESS), 
      Early Origin of the Child's Health and Development (ORCHAD) Team, Inserm, 
      Villejuif, France.
AD  - Universite Paris Descartes, Villejuif, France.
FAU - Bernard, Jonathan Y
AU  - Bernard JY
AD  - U1153 Epidemiology and Biostatistics Sorbonne Paris Cite Research Centre (CRESS), 
      Early Origin of the Child's Health and Development (ORCHAD) Team, Inserm, 
      Villejuif, France.
AD  - Universite Paris Descartes, Villejuif, France.
AD  - Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology 
      and Research (A*STAR), Singapore, Singapore.
FAU - Beranger, Remi
AU  - Beranger R
AD  - Inserm U1085-IRSET, Universite Rennes 1, Rennes, France.
FAU - Slama, Remy
AU  - Slama R
AD  - Institute for Advanced Biosciences (IAB), INSERM U1209, CNRS UMR 5309, Universite 
      Grenoble Alpes, 38000, Grenoble, France.
FAU - Philippat, Claire
AU  - Philippat C
AD  - Institute for Advanced Biosciences (IAB), INSERM U1209, CNRS UMR 5309, Universite 
      Grenoble Alpes, 38000, Grenoble, France.
CN  - EDEN mother-child study group
LA  - eng
GR  - EST-2010/2/126/Agence Nationale de Securite Sanitaire de l'Alimentation, de 
      l'Environnement et du Travail/International
GR  - 2015-00059545/Fondation de France/International
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180220
PL  - England
TA  - Environ Health
JT  - Environmental health : a global access science source
JID - 101147645
RN  - 0 (Environmental Pollutants)
RN  - 0 (Phenols)
RN  - 0 (Phthalic Acids)
SB  - IM
MH  - Child, Preschool
MH  - Environmental Pollutants/*urine
MH  - Female
MH  - France
MH  - Humans
MH  - Intelligence
MH  - Intelligence Tests
MH  - Male
MH  - *Maternal Exposure
MH  - Phenols/*urine
MH  - Phthalic Acids/*urine
MH  - Pregnancy
MH  - Prospective Studies
PMC - PMC5819230
OTO - NOTNLM
OT  - Bisphenol A
OT  - Cognitive function
OT  - Endocrine disruptors
OT  - Intelligence quotient
OT  - Parabens
OT  - Phthalate
OT  - Prenatal exposure
OT  - Triclosan
COIS- ETHICS APPROVAL AND CONSENT TO PARTICIPATE: All participants gave informed 
      written consent for themselves and for their children to be included in the 
      cohort. CONSENT FOR PUBLICATION: Not applicable. COMPETING INTERESTS: The authors 
      declare that they have no competing interests. PUBLISHER'S NOTE: Springer Nature 
      remains neutral with regard to jurisdictional claims in published maps and 
      institutional affiliations.
FIR - Charles, M A
IR  - Charles MA
FIR - de Agostini, M
IR  - de Agostini M
FIR - Forhan, A
IR  - Forhan A
FIR - Heude, B
IR  - Heude B
FIR - Ducimetiere, P
IR  - Ducimetiere P
FIR - Kaminski, M
IR  - Kaminski M
FIR - Saurel-Cubizolles, M J
IR  - Saurel-Cubizolles MJ
FIR - Dargent-Molina, P
IR  - Dargent-Molina P
FIR - Fritel, X
IR  - Fritel X
FIR - Larroque, B
IR  - Larroque B
FIR - Lelong, N
IR  - Lelong N
FIR - Marchand, L
IR  - Marchand L
FIR - Nabet, C
IR  - Nabet C
FIR - Annesi-Maesano, I
IR  - Annesi-Maesano I
FIR - Slama, R
IR  - Slama R
FIR - Goua, V
IR  - Goua V
FIR - Magnin, G
IR  - Magnin G
FIR - Hankard, R
IR  - Hankard R
FIR - Thiebaugeorges, O
IR  - Thiebaugeorges O
FIR - Schweitzer, M
IR  - Schweitzer M
FIR - Foliguet, B
IR  - Foliguet B
FIR - Job-Spira, N
IR  - Job-Spira N
FIR - Bernard, J Y
IR  - Bernard JY
FIR - de Lauzon-Guillain, B
IR  - de Lauzon-Guillain B
FIR - Germa, A
IR  - Germa A
FIR - Pierre, F
IR  - Pierre F
FIR - Lepeule, J
IR  - Lepeule J
FIR - Botton, J
IR  - Botton J
EDAT- 2018/02/21 06:00
MHDA- 2018/12/18 06:00
PMCR- 2018/02/20
CRDT- 2018/02/21 06:00
PHST- 2017/09/08 00:00 [received]
PHST- 2018/01/29 00:00 [accepted]
PHST- 2018/02/21 06:00 [entrez]
PHST- 2018/02/21 06:00 [pubmed]
PHST- 2018/12/18 06:00 [medline]
PHST- 2018/02/20 00:00 [pmc-release]
AID - 10.1186/s12940-018-0359-0 [pii]
AID - 359 [pii]
AID - 10.1186/s12940-018-0359-0 [doi]
PST - epublish
SO  - Environ Health. 2018 Feb 20;17(1):17. doi: 10.1186/s12940-018-0359-0.